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Bengal Special offer:
4 Bengal Specific DNA tests for just £72.00 incl VAT
Bengal DNA bundle (rdAc-PRA + b-PRA + PK-Def + Blood Groups) 



British Special offer:
4 Breed Specific DNA tests for just £72.00 incl VAT
British Short / Long Hair DNA bundle (PKD + pd-PRA + ALS + Blood Groups)



Burmese Special offer:
4 Breed Specific DNA tests for just £72.00 incl VAT
Burmese DNA bundle (Hypokalemia (BHK) + Head Defect + Gangliosidosis (GM2) + Blood Groups



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5 Breed Specific DNA tests for just £72.00 incl VAT
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Feline Special Offer:
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HCM, HCR, GSD4, PKD, PRA, PK-Def., SMA, Blood Groups

new bundle: White Swiss Shepherd DNA bundle
new test:      Limb Girdle Muscular Dystrophy (LGMD) in Dachhsund  
new test:      Dyserythropoietic Anemia and Myopathy Syndrome (DAMS) in English Springer Spaniel
new Kennel Club DNA testing schemes with LABOKLIN:
   Dyserythropoietic Anemia and Myopathy Syndrome (DAMS) in English Springer Spaniel
  Primary Open Angle Glaucoma (POAG) in Basset Hound, Basset Fauve de Bretagne (Petit), and Norwegian Elkhound


Dermatology Symptoms DNA bundle

Test number: 8901

Price: £ 150.00 (including VAT) for all 15 tests
Symptom related DNA bundle

Dermatology Symptoms DNA bundle

(Dry Eye Curly Coat, DEB, ED/SFS, EHK, ECLE, Congenital ichthyosis, HNPK, Ichthyosis, Ichthyosis Type 2, JEB, LAD, D-Locus, D-locus rare variants)

this bundle includes 15 tests

This bundle includes DNA tests which are most relevant to the dermatological symptoms. It is useful to vets who are presented with patients exhibiting these symptoms and so all available genetic variants will be tested regardless of the breed.


  1 ) Dry Eye and Curly Coat syndrome (CCS)

Breeds
Cavalier King Charles Spaniel , Cavapoo .
Kennel Club
This test is part of the Official UK Kennel Club DNA Testing Scheme in Cavalier King Charles Spaniel.

for UK registered dogs, Laboklin can send results of the tests which are part of the Official UK Kennel Club DNA testing scheme to the Kennel Club (KC) to be recorded and published as part of the Kennel Club scheme. Results will only be recorded and published by the KC if the result report includes the dog’s microchip or tattoo number along with either the dog’s registered name or registered number. Any test results that do not carry these identifying features will not be recorded by the Kennel Club.

In order to ensure that test results are sent to the Kennel Club, customers must also sign the declaration section on the order form to give Laboklin permission to do so.

important: When you sign the declaration, Laboklin will send the results to the KC on your behalf, and you do not need to send them to the KC yourself again to avoid unnecessary duplications.

The Disease
Affected dog puppies suffer from keratoconjunctivitis sicca from eyelid opening, abnormal (rough/curly) coat and are usually smaller than littermates. Footpads are hyper keratinised from young adulthood including nail growth abnormalities and intermittent sloughing, pain and lameness.
Description

We also have a special offer:

Episodic Falling + Dry Eye and Curly Coat syndrome
LIMITED PERIOD SPECIAL OFFER PRICE ONLY £66 (INCL VAT) FOR BOTH TESTS.

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Sample Requirements
Whole blood in EDTA tube (0.5 - 1 ml) or Buccal Swabs.
Turnaround
1 - 2 weeks

  2 ) Dystrophic Epidermolysis Bullosa (DEB)

Breed
Central Asian Shepherds .
The Disease
Dystrophic Epidermolysis Bullosa (DEB) is a rare inherited mechanobullous disorder affecting teh Central Asian Shepherd breed. The disease is characterised by blistering in the skin and the mucosal membranes.
 
Further reading
Dystrophic Epidermolysis Bullosa (DEB) in Central Asian Shepherdshtml file
Sample Requirements
Whole blood in EDTA tube (0.5 - 1 ml) or Buccal Swabs.
Turnaround
1-2 weeks

  3 ) Ectodermal Dysplasia / Skin Fragility Syndrome (ED / SFS)

Breed
Chesapeake Bay Retriever .
The Disease
At birth, the skin of affected dogs is abnormally pale and translucent on ears, feet, nose and mouth area. Spontaneous sloughing of the nose and footpad epithelium and bleeding of ear tips occur if traumatized. Lips and facial skin layers also slough when rubbed or licked by mother. Affected dogs have to be euthanized.
Trait of Inheritance
Autosomal recessive mode of inheritance

Inheritance : AUTOSOMAL RECESSIVE trait


 

Sire

 

Dam

 

Offspring

         
clear
clear
100% clear
         
clear
carrier
50%  clear + 50% carriers
         
clear
affected
100% carriers
         
carrier
clear
50%  clear + 50% carriers
         
carrier
carrier
25% clear + 25% affected + 50% carriers
         
carrier
affected
50% carriers + 50% affected
         
affected
clear
100%  carriers
         
affected
carrier
50% carriers + 50% affected
         
affected
affected
100% affected

 


Clear

Genotype: N / N [ Homozygous normal ]

The dog is noncarrier of the mutant gene.

It is very unlikely that the dog will develop Ectodermal Dysplasia / Skin Fragility Syndrome (ED / SFS). The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.

 

Carrier

Genotype: N / ED [ Heterozygous ]

The dog carries one copy of the mutant gene and one copy of the normal gene.

It is very unlikely that the dog will develop Ectodermal Dysplasia / Skin Fragility Syndrome (ED / SFS) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%.

Carriers should only be bred to clear dogs.

Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)

 

Affected

Genotype: ED / ED [ Homozygous mutant ]

 

The dog carries two copies of the mutant gene and therefore it will pass the mutant gene to its entire offspring.

The dog is likely to develop Ectodermal Dysplasia / Skin Fragility Syndrome (ED / SFS) and will pass the mutant gene to its entire offspring
Sample Requirements
Buccal Swabs or 0.5 - 1 ml blood in EDTA Blood Tube
Turnaround
2 - 3 weeks

  4 ) Ichthyosis ( Epidermolytic Hyperkeratosis (EHK) )

Breed
Norfolk Terrier .
The Disease
Epidermolytic hyperkeratosis is an inherited skin disease characterised by fragile skin, hyperkeratosis, and hyperpigmentation.
Trait of Inheritance
.

Inheritance : AUTOSOMAL RECESSIVE trait


 

Sire

 

Dam

 

Offspring

         
clear
clear
100% clear
         
clear
carrier
50%  clear + 50% carriers
         
clear
affected
100% carriers
         
carrier
clear
50%  clear + 50% carriers
         
carrier
carrier
25% clear + 25% affected + 50% carriers
         
carrier
affected
50% carriers + 50% affected
         
affected
clear
100%  carriers
         
affected
carrier
50% carriers + 50% affected
         
affected
affected
100% affected

 


Clear

Genotype: N / N [ Homozygous normal ]

The dog is noncarrier of the mutant gene.

It is very unlikely that the dog will develop Ichthyosis ( Epidermolytic Hyperkeratosis (EHK) ). The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.

 

Carrier

Genotype: N / KRT10 [ Heterozygous ]

The dog carries one copy of the mutant gene and one copy of the normal gene.

It is very unlikely that the dog will develop Ichthyosis ( Epidermolytic Hyperkeratosis (EHK) ) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%.

Carriers should only be bred to clear dogs.

Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)

 

Affected

Genotype: KRT10 / KRT10 [ Homozygous mutant ]

 

The dog carries two copies of the mutant gene and therefore it will pass the mutant gene to its entire offspring.

The dog is likely to develop Ichthyosis ( Epidermolytic Hyperkeratosis (EHK) ) and will pass the mutant gene to its entire offspring
Sample Requirements
Whole blood in EDTA tube (0.5 - 1 ml) or Buccal Swabs.
Turnaround
1 - 2 weeks

  5 ) Exfoliative Cutaneous Lupus Rrythematosus ( ECLE ) / Lupoid Dermatosis

Breeds
German Shorthair Pointer , Hungarian Vizsla (Magyar Vizsla / Smooth haired) , Hungarian Wirehaired Vizsla (Vizslak) .
The Disease
Exfoliative Cutaneous Lupus Erythematosus (ECLE), which is also known as Lupoid Dermatosis is an inherited monogenic (controlled by one gene) disease that has been observed in the German Shorthaired Pointer and Hungarian Vizsla breeds. Symptoms start in the first year of age and include skin lesions, lameness, scaling, erythema (reddening of the skin), erosions/ulcers, scarring, disfiguration, decreased quality of life, progresses to joint pain, oligospermia (low sperm count) in males which progressed to azoospermia (absence of sperm), irregular heat cycles in females. Dogs with this disease have dramatically shortened life expectancies and are generally humanely euthanized upon diagnosis.

The mode of inheritance is autosomal recessive, which means that the disease occur when the puppy inherits two copies of the mutation, one from each parent.

Sample Requirements
Whole blood in EDTA tube (0.5 - 1 ml) or Buccal Swabs.
Turnaround
1-3 weeks

  6 ) Ichthyosis (Congenital Ichthyosis / Great Dane Ichthyosis)

Breed
Great Dane .
The Disease
Congenital Ichthyosis / Great Dane Ichthyosis is an inherited disorder characterised by generalized severe hyperkeratosis and the formation of a strongly wrinkled, thickened and scaling skin especially in the region of the eyes and nose. The skin becomes dry and loses its elasticity, it becomes lichenified with untidy appearance. The skin around the eyes becomes swollen and imedes the opening of the puppy’s eyes in some cases.

In-between the wrinkles the exudative character of the skin promotes secondary infections.

Patho-histological examinations indicated a congenital non-epidermolytic ichthyosis of a lamellar type.

Trait of Inheritance
.

Inheritance : AUTOSOMAL RECESSIVE trait


 

Sire

 

Dam

 

Offspring

         
clear
clear
100% clear
         
clear
carrier
50%  clear + 50% carriers
         
clear
affected
100% carriers
         
carrier
clear
50%  clear + 50% carriers
         
carrier
carrier
25% clear + 25% affected + 50% carriers
         
carrier
affected
50% carriers + 50% affected
         
affected
clear
100%  carriers
         
affected
carrier
50% carriers + 50% affected
         
affected
affected
100% affected

 


Clear

Genotype: N / N [ Homozygous normal ]

The dog is noncarrier of the mutant gene.

It is very unlikely that the dog will develop Ichthyosis (Congenital Ichthyosis / Great Dane Ichthyosis). The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.

 

Carrier

Genotype: N / SLC27A4 [ Heterozygous ]

The dog carries one copy of the mutant gene and one copy of the normal gene.

It is very unlikely that the dog will develop Ichthyosis (Congenital Ichthyosis / Great Dane Ichthyosis) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%.

Carriers should only be bred to clear dogs.

Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)

 

Affected

Genotype: SLC27A4 / SLC27A4 [ Homozygous mutant ]

 

The dog carries two copies of the mutant gene and therefore it will pass the mutant gene to its entire offspring.

The dog is likely to develop Ichthyosis (Congenital Ichthyosis / Great Dane Ichthyosis) and will pass the mutant gene to its entire offspring
Sample Requirements
Whole blood in EDTA tube (0.5 - 1 ml) or Buccal Swabs.
Turnaround
1 - 2 weeks

  7 ) Hereditary Nasal Parakeratosis (HNPK)

License
Laboklin acquired a worldwide license for HNPK
Breed
Labrador Retriever .
Kennel Club
This test is part of the Official UK Kennel Club DNA Testing Scheme in Labrador Retriever.

for UK registered dogs, Laboklin can send results of the tests which are part of the Official UK Kennel Club DNA testing scheme to the Kennel Club (KC) to be recorded and published as part of the Kennel Club scheme. Results will only be recorded and published by the KC if the result report includes the dog’s microchip or tattoo number along with either the dog’s registered name or registered number. Any test results that do not carry these identifying features will not be recorded by the Kennel Club.

In order to ensure that test results are sent to the Kennel Club, customers must also sign the declaration section on the order form to give Laboklin permission to do so.

important: When you sign the declaration, Laboklin will send the results to the KC on your behalf, and you do not need to send them to the KC yourself again to avoid unnecessary duplications.

The Disease
In nasal parakeratosis a genetic disorder causes the dogs nose to dry out. Especially, the dorsal surface of the planum forms keratinous scales, which adhere to the nose. Bloody fissures might occur in this structures, leading to chronic irritation and inflammation of the noses skin. The colour of the skin might change from dark to lighter colour. Affected dogs develop first symptoms at the age of six month to one year. The nose can be treated with Vaseline, propylene glycol or salicylic acid containing products to ease the symptoms.
Trait of Inheritance
Autosomal recessive

Inheritance : AUTOSOMAL RECESSIVE trait


 

Sire

 

Dam

 

Offspring

         
clear
clear
100% clear
         
clear
carrier
50%  clear + 50% carriers
         
clear
affected
100% carriers
         
carrier
clear
50%  clear + 50% carriers
         
carrier
carrier
25% clear + 25% affected + 50% carriers
         
carrier
affected
50% carriers + 50% affected
         
affected
clear
100%  carriers
         
affected
carrier
50% carriers + 50% affected
         
affected
affected
100% affected

 


Clear

Genotype: N / N [ Homozygous normal ]

The dog is noncarrier of the mutant gene.

It is very unlikely that the dog will develop Hereditary Nasal Parakeratosis (HNPK). The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.

 

Carrier

Genotype: N / HNPK [ Heterozygous ]

The dog carries one copy of the mutant gene and one copy of the normal gene.

It is very unlikely that the dog will develop Hereditary Nasal Parakeratosis (HNPK) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%.

Carriers should only be bred to clear dogs.

Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)

 

Affected

Genotype: HNPK / HNPK [ Homozygous mutant ]

 

The dog carries two copies of the mutant gene and therefore it will pass the mutant gene to its entire offspring.

The dog is likely to develop Hereditary Nasal Parakeratosis (HNPK) and will pass the mutant gene to its entire offspring
Description

The causative gene defect was discovered by scientists of the institute for genetics, Vetsuisse-faculty of the university Bern (Group of Prof. Tosso Leeb).

Sample Requirements
Whole blood in EDTA tube (0.5 - 1 ml) or Buccal Swabs.
Turnaround
1 - 2 weeks

  8 ) Ichthyosis ( ICH ) *

Kennel Club DNA Testing Scheme
Official UK Kennel Club DNA testing scheme in Golden Retriever from January 2014
Breeds
Golden Retriever , Goldendoodle .
Kennel Club
This test is part of the Official UK Kennel Club DNA Testing Scheme in Golden Retriever.

for UK registered dogs, Laboklin can send results of the tests which are part of the Official UK Kennel Club DNA testing scheme to the Kennel Club (KC) to be recorded and published as part of the Kennel Club scheme. Results will only be recorded and published by the KC if the result report includes the dog’s microchip or tattoo number along with either the dog’s registered name or registered number. Any test results that do not carry these identifying features will not be recorded by the Kennel Club.

In order to ensure that test results are sent to the Kennel Club, customers must also sign the declaration section on the order form to give Laboklin permission to do so.

important: When you sign the declaration, Laboklin will send the results to the KC on your behalf, and you do not need to send them to the KC yourself again to avoid unnecessary duplications.

The Disease

Golden Retriever Ichthyosis (GR-ICH)

Ichthyosis ( ICH ) is a genetic disease causing dysfunction of the keratin in the skin, which leads to the production of large, differently pigmented skin scales. Due to the fish-like look of this scales the name was formed from the Greek word for fish: „Ichthýs“. Additionally, the pigmentation of the skin can be altered.

Dogs which are affected by this dermatosis develop first symptoms soon after birth. Unfortunately, there is no treatment for this disease. In some cases, formation of scales decreases in old dogs.

Please note that there is another form of Ichthyosis affecting the Golden Retriever breed, Ichthyosis Type 2, click here for more details. you need both tests for complete analysis

Trait of Inheritance
Autosomal recessive

Inheritance : AUTOSOMAL RECESSIVE trait


 

Sire

 

Dam

 

Offspring

         
clear
clear
100% clear
         
clear
carrier
50%  clear + 50% carriers
         
clear
affected
100% carriers
         
carrier
clear
50%  clear + 50% carriers
         
carrier
carrier
25% clear + 25% affected + 50% carriers
         
carrier
affected
50% carriers + 50% affected
         
affected
clear
100%  carriers
         
affected
carrier
50% carriers + 50% affected
         
affected
affected
100% affected

 


Clear

Genotype: N / N [ Homozygous normal ]

The dog is noncarrier of the mutant gene.

It is very unlikely that the dog will develop Ichthyosis ( ICH ) *. The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.

 

Carrier

Genotype: N / Ichthyosis [ Heterozygous ]

The dog carries one copy of the mutant gene and one copy of the normal gene.

It is very unlikely that the dog will develop Ichthyosis ( ICH ) * but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%.

Carriers should only be bred to clear dogs.

Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)

 

Affected

Genotype: Ichthyosis / Ichthyosis [ Homozygous mutant ]

 

The dog carries two copies of the mutant gene and therefore it will pass the mutant gene to its entire offspring.

The dog is likely to develop Ichthyosis ( ICH ) * and will pass the mutant gene to its entire offspring
Sample Requirements
Whole blood in EDTA tube (0.5 - 1 ml) or Buccal Swabs.
Turnaround
2 - 3 weeks

  9 ) Ichthyosis type 2

Breeds
Golden Retriever , Goldendoodle .
The Disease
Ichthyosis type 2 is another variant which causes Ichthyosis in Golden Retriever, this test helps in explaining cases which was tested negative for the already known Ichrthyosis variant. Ichthyosis is a genetic disease causing dysfunction of the keratin in the skin, which leads to the production of large, differently pigmented skin scales. Due to the fish-like look of this scales the name was formed from the Greek word for fish: „Ichthýs“. Additionally, the pigmentation of the skin can be altered.

Dogs which are affected by this dermatosis develop first symptoms soon after birth. Unfortunately, there is no treatment for this disease. In some cases, formation of scales decreases in old dogs.

Please note that there is another form of Ichthyosis affecting the golden retriever breed, Ichthyosis or Ichthyosis Type 1, click here for more details. you need both tests for complete analysis

Trait of Inheritance
Autosomal recessive

Inheritance : AUTOSOMAL RECESSIVE trait


 

Sire

 

Dam

 

Offspring

         
clear
clear
100% clear
         
clear
carrier
50%  clear + 50% carriers
         
clear
affected
100% carriers
         
carrier
clear
50%  clear + 50% carriers
         
carrier
carrier
25% clear + 25% affected + 50% carriers
         
carrier
affected
50% carriers + 50% affected
         
affected
clear
100%  carriers
         
affected
carrier
50% carriers + 50% affected
         
affected
affected
100% affected

 


Clear

Genotype: N / N [ Homozygous normal ]

The dog is noncarrier of the mutant gene.

It is very unlikely that the dog will develop Ichthyosis type 2. The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.

 

Carrier

Genotype: N / Ichthyosis [ Heterozygous ]

The dog carries one copy of the mutant gene and one copy of the normal gene.

It is very unlikely that the dog will develop Ichthyosis type 2 but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%.

Carriers should only be bred to clear dogs.

Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)

 

Affected

Genotype: Ichthyosis / Ichthyosis [ Homozygous mutant ]

 

The dog carries two copies of the mutant gene and therefore it will pass the mutant gene to its entire offspring.

The dog is likely to develop Ichthyosis type 2 and will pass the mutant gene to its entire offspring
Sample Requirements
Whole blood in EDTA tube (0.5 - 1 ml) or Buccal Swabs.
Turnaround
1 - 3 weeks

  10 ) JEB (Junctional Epidermolysis bullosa)

Breed
German Shorthair Pointer .
The Disease
EB (Junctional Epidermolysis bullosa) is a blistering disorder of the skin and mucous membranes in which tissue separation occurs within the lamina lucida of the basement membrane zone at the dermal-epidermal junction. Affected dogs show erosion and encrustation in the field of the balls, knees, elbows, ankle joints, carpal bones, hips, lips and tongue.
Trait of Inheritance
JEB in German Pointers is an inherited autosomal recessive trait. This means that a dog can be clear (homozygous normal), affected, or a carrier (heterozygous). The carriers can spread the diseased gene in the population. Therefore, reliable information on non-affected dogs is the key to controlling this disease.

Inheritance : AUTOSOMAL RECESSIVE trait


 

Sire

 

Dam

 

Offspring

         
clear
clear
100% clear
         
clear
carrier
50%  clear + 50% carriers
         
clear
affected
100% carriers
         
carrier
clear
50%  clear + 50% carriers
         
carrier
carrier
25% clear + 25% affected + 50% carriers
         
carrier
affected
50% carriers + 50% affected
         
affected
clear
100%  carriers
         
affected
carrier
50% carriers + 50% affected
         
affected
affected
100% affected

 


Clear

Genotype: N / N [ Homozygous normal ]

The dog is noncarrier of the mutant gene.

It is very unlikely that the dog will develop JEB (Junctional Epidermolysis bullosa). The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.

 

Carrier

Genotype: N / JEB [ Heterozygous ]

The dog carries one copy of the mutant gene and one copy of the normal gene.

It is very unlikely that the dog will develop JEB (Junctional Epidermolysis bullosa) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%.

Carriers should only be bred to clear dogs.

Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)

 

Affected

Genotype: JEB / JEB [ Homozygous mutant ]

 

The dog carries two copies of the mutant gene and therefore it will pass the mutant gene to its entire offspring.

The dog is likely to develop JEB (Junctional Epidermolysis bullosa) and will pass the mutant gene to its entire offspring
Description

The genetic test detects a SNP mutation that is inherited together with the responsible mutation. This method provides a very high accuracy test and can be done at any age. It offers the possibility to distinguish not only between affected and clear dogs, but also to identify clinically healthy carriers. This is an essential information for controlling the disease in the breed, as carriers are able to spread the disease in the population, but can not be identified by means of common laboratory diagnostic. The DNA test does not provide informations about onset of clinical signs and the severity of disease symptoms.

Sample Requirements
Whole blood in EDTA tube (0.5 - 1 ml) or Buccal Swabs.
Turnaround
2 - 3 weeks

  11 ) Lethal Acrodematitis ( LAD )

Breeds
Bull Terrier , Miniature Bull Terrier .
Trait of Inheritance
.

Inheritance : AUTOSOMAL RECESSIVE trait


 

Sire

 

Dam

 

Offspring

         
clear
clear
100% clear
         
clear
carrier
50%  clear + 50% carriers
         
clear
affected
100% carriers
         
carrier
clear
50%  clear + 50% carriers
         
carrier
carrier
25% clear + 25% affected + 50% carriers
         
carrier
affected
50% carriers + 50% affected
         
affected
clear
100%  carriers
         
affected
carrier
50% carriers + 50% affected
         
affected
affected
100% affected

 


Clear

Genotype: N / N [ Homozygous normal ]

The dog is noncarrier of the mutant gene.

It is very unlikely that the dog will develop Lethal Acrodematitis ( LAD ). The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.

 

Carrier

Genotype: N / MKLN1 [ Heterozygous ]

The dog carries one copy of the mutant gene and one copy of the normal gene.

It is very unlikely that the dog will develop Lethal Acrodematitis ( LAD ) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%.

Carriers should only be bred to clear dogs.

Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)

 

Affected

Genotype: MKLN1 / MKLN1 [ Homozygous mutant ]

 

The dog carries two copies of the mutant gene and therefore it will pass the mutant gene to its entire offspring.

The dog is likely to develop Lethal Acrodematitis ( LAD ) and will pass the mutant gene to its entire offspring
Description

Lethal Acrodematitis ( LAD ) is an inherited disease affecting the Bull Terriers and Miniature Bull Terriers breeds. The disease is characterised by poor growth, immune deficiency, and skin lesions, especially at the paws.Symptoms includ erythema and adherent scales on the the feet, elbows, hocks and muzzle. Hyperkeratosis of the foot pads is also seen. Immunodeficiency increases susceptibility to microbial infections including skin disease of the face and feet. Signs include stunting, splayed digits and eating difficulties. In older dogs, paronychia, nail disease and hyperkeratosis of the footpads develops, becoming severe in dogs over six months of age.

Puppies suffering from this condition have a greatly reduced lifespan due to infection, and they are often euthanized when the condition becomes very severe and painful.

The disease is caused by a mutation in the MKLN1 gene and a DNA test is now available at Laboklin.

Sample Requirements
Whole blood in EDTA tube (0.5 - 1 ml) or Buccal Swabs.
Turnaround
1-2 weeks

  12 ) Coat Colour: D-Locus D1 ( Dilution / Dilute )

Breeds
All Dog Breeds , Border Collie , Boston Terrier , Bulldog (English) , Chihuahua , Doberman Pinscher , French Bull Dog , German Pinscher , Koolie ( Australian Koolie ) , Labrador Retriever , Large Munsterlander , Miniature Pinscher , Newfoundland , Rhodesian Ridgeback , Staffordshire Bull Terrier .
Kennel Club
This test is part of the Official UK Kennel Club DNA Testing Scheme in Labrador Retriever.

for UK registered dogs, Laboklin can send results of the tests which are part of the Official UK Kennel Club DNA testing scheme to the Kennel Club (KC) to be recorded and published as part of the Kennel Club scheme. Results will only be recorded and published by the KC if the result report includes the dog’s microchip or tattoo number along with either the dog’s registered name or registered number. Any test results that do not carry these identifying features will not be recorded by the Kennel Club.

In order to ensure that test results are sent to the Kennel Club, customers must also sign the declaration section on the order form to give Laboklin permission to do so.

important: When you sign the declaration, Laboklin will send the results to the KC on your behalf, and you do not need to send them to the KC yourself again to avoid unnecessary duplications.

Description

The D locus is the primary locus associated with diluted pigment, which results in coats that would otherwise be black or brown instead showing up as gray, or blue in the case of black, and pale brown or Isabella / Lilac / Lavender in the case of brown. The melanophilin gene has recently been shown to be responsible, but not all of the dilute causing mutations have been identified yet.

A recessive mutation in the melanophilin gene was identified as the cause of colour dilution phenotypes in the dog. Two alleles (variants) are described: the dominant full colour (D) and the recessive dilute (d). Two copies of dilute are needed to lighten black pigment to blue / grey and brown (liver / chocolate / cocoa / red in border collie) pigment to lilac / isabella / lavender (in Pomeranian). A diagnostic DNA test identifies the specific variants of the MLPH gene.

Please note that in the Chow Chow, Thai Ridgeback and Sloughi breeds, there is another mutation that can cause coat colour dilution, it is the D2 Locus mutation and in those breeds both D1 Locus and D2 Locus mutations must be tested for complete analysis.

Please note that in the Chihuahua, Italian Greyhound, Mudi (Hungarian Mudi) and Hungarian Pumi breeds, there is another mutation that can cause coat colour dilution, it is the D3 Locus mutation and in those breeds both D 1Locus and D3 Locus mutations must be tested for complete analysis.

Please note that dilution (blue, lilac, isabella, etc) is just a colour and that it is not known to be associated with any health conditions

KC

Please note that this test is part of the KC DNA testing scheme in Labrador Retriever. If you would like Laboklin to send the result to the KC, please sign the declaration at the bottom of the form to give us a permission . Please note that the KC will oly publish clear results but would make a note of any result received.


Colour Dilution Alopecia (CDA)

There is no test for CDA and there is no evidence that CDA is caused by dilution

CDA is a genetic recessive inherited condition that causes patches of hair thinning or loss and may also include flaky and/or itchy skin. CDA occurs in dilute dogs (homozygous for the dilute gene d/d) in some breeds, however there is no direct link between CDA and the dilute gene, and there is no evidence that the dilute gene is responsible for CDA. It is though that there are other, not yet identified, genetic factors causing CDA in dilute dogs of some breeds. Any colour can carry CDA but symptoms are only expressed in blue and isabella dogs affected by CDA.

breeding

Since CDA is a recessive gene, it can, in theory, be bred out of most lines by breeding dilute dogs with healthy coats. Breeding healthy dilute dogs with healthy dilute dogs is one way to reduce the occurrence of CDA until testing becomes available.

Breeds known to be affected by CDA:

  • Bernese Mountain Dog
  • Boston Terrier
  • Chihuahua
  • Chow Chow
  • Dachshund
  • Doberman Pinscher
  • Great Dane
  • Irish Setter
  • Italian Greyhound
  • Mudi (Hungarian Mudi)
  • Newfoundland
  • Saluki
  • Schipperke
  • Shetland Sheepdog
  • Standard Poodle
  • Whippet
  • Yorkshire Terrier

 
Further reading
Coat Colour Inheritance Chartshtml file
Sample Requirements
Whole blood in EDTA tube (0.5 - 1 ml) or Buccal Swabs.
Turnaround
1 - 3 weeks

  13 ) Coat Colour: D-Locus D2 / D3 rare variants ( Dilution / Dilute )

Breeds
Chihuahua , Chinese Chow Chow , Pumi ( Hungarian Pumi / Pumik ) , Italian Greyhound , Mudi , Sloughi , Thai Ridgeback .
Description

This test is for the rare Dilution variants d2 and d3 at the D-Locus.

'd2' variant

The D2 locus is another dilution mutation that dilutes coat colour but this mutatoin is only found in the Chow Chow,Thai Ridgeback and Sloughi breeds, which must be tested for both d1 Locus as well as the d2 Locus mutations for a complete analysis.

You can take advantage of our special offer 'second coat colour test at half price'.

'd3' variant

The D3 locus is another dilution mutation that dilutes coat colour but this mutatoin is only found in the Chihuahua, Pumi (Hungarian Pumi / Pumik), Mudi (Hungarian Mudi) and Italian Greyhound breeds, which must be tested for both d1 Locus as well as the d3 Locus mutations for a complete analysis.

You can take advantage of our special offer 'second coat colour test at half price'.

For more information about the D1 Locus please click here D Locus

important note

Please note that when you order this test we will only perform the test for the variant that is relevant to your breed. Either d2 or d3

Please note that dilution (blue, lilac, isabella, etc) is just a colour and that it is not known to be associated with any health conditions


Colour Dilution Alopecia (CDA)

There is no test for CDA and there is no evidence that CDA is caused by dilution

CDA is a genetic recessive inherited condition that causes patches of hair thinning or loss and may also include flaky and/or itchy skin. CDA occurs in dilute dogs (homozygous for the dilute gene d/d) in some breeds, however there is no direct link between CDA and the dilute gene, and there is no evidence that the dilute gene is responsible for CDA. It is though that there are other, not yet identified, genetic factors causing CDA in dilute dogs of some breeds. Any colour can carry CDA but symptoms are only expressed in blue and isabella dogs affected by CDA.

breeding

Since CDA is a recessive gene, it can, in theory, be bred out of most lines by breeding dilute dogs with healthy coats. Breeding healthy dilute dogs with healthy dilute dogs is one way to reduce the occurrence of CDA until testing becomes available.

Breeds known to be affected by CDA:

  • Bernese Mountain Dog
  • Boston Terrier
  • Chihuahua
  • Chow Chow
  • Dachshund
  • Doberman Pinscher
  • Great Dane
  • Irish Setter
  • Italian Greyhound
  • Mudi (Hungarian Mudi)
  • Newfoundland
  • Saluki
  • Schipperke
  • Shetland Sheepdog
  • Standard Poodle
  • Whippet
  • Yorkshire Terrier

 
Further reading
Coat Colour Inheritance Chartshtml file
Sample Requirements
Buccal Swabs or 0.5 - 1 ml blood in EDTA Blood Tube
Turnaround
1 - 3 weeks

  14 ) Hereditary Nasal Parakeratosis (HNPK)

Breed
Greyhound .
The Disease
Hereditary nasal parakeratosis (HNPK) is an inherited skin disorder affecting the greyhound breed. The disease is characterised by development of scales and crusts on the nosepad. Occasionally affected dogs also develop painful fissures on the nose. THe mode of inheritance if recessive, which means that the dog must inherit two copies of the mutation (one from each parent ) to develop the disease.
Trait of Inheritance
.

Inheritance : AUTOSOMAL RECESSIVE trait


 

Sire

 

Dam

 

Offspring

         
clear
clear
100% clear
         
clear
carrier
50%  clear + 50% carriers
         
clear
affected
100% carriers
         
carrier
clear
50%  clear + 50% carriers
         
carrier
carrier
25% clear + 25% affected + 50% carriers
         
carrier
affected
50% carriers + 50% affected
         
affected
clear
100%  carriers
         
affected
carrier
50% carriers + 50% affected
         
affected
affected
100% affected

 


Clear

Genotype: N / N [ Homozygous normal ]

The dog is noncarrier of the mutant gene.

It is very unlikely that the dog will develop Hereditary Nasal Parakeratosis (HNPK). The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.

 

Carrier

Genotype: N / HNPK [ Heterozygous ]

The dog carries one copy of the mutant gene and one copy of the normal gene.

It is very unlikely that the dog will develop Hereditary Nasal Parakeratosis (HNPK) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%.

Carriers should only be bred to clear dogs.

Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)

 

Affected

Genotype: HNPK / HNPK [ Homozygous mutant ]

 

The dog carries two copies of the mutant gene and therefore it will pass the mutant gene to its entire offspring.

The dog is likely to develop Hereditary Nasal Parakeratosis (HNPK) and will pass the mutant gene to its entire offspring
Sample Requirements
Whole blood in EDTA tube (0.5 - 1 ml) or Buccal Swabs.
Turnaround
1-2 weeks

  15 ) Ichthyosis

Breed
American Bulldog .
The Disease
Ichthyosis is an inherited disease that affects the American Bulldog breed. It is characterised by the presence of dishevelled coat hair shortly after birth, generalized scaling, and sticky brown scales with reddening of the abdominal skin.

A dog can be either clear (N/N), Carrier (N / ICH) or affected (ICH/ICH). Due to the recessive mode of inheritance only Affected (ICH/ICH) dogs will exhibit symptoms of the disease. Clear and Carriers will not display any symptoms, however, carriers can pass the mutation to their offspring and therefore carriers must only be bred to clear dogs to avoid having affected puppies.

A DNA test is now available from Laboklin and can help you to identify if your dog carry the mutation.

Trait of Inheritance
.

Inheritance : AUTOSOMAL RECESSIVE trait


 

Sire

 

Dam

 

Offspring

         
clear
clear
100% clear
         
clear
carrier
50%  clear + 50% carriers
         
clear
affected
100% carriers
         
carrier
clear
50%  clear + 50% carriers
         
carrier
carrier
25% clear + 25% affected + 50% carriers
         
carrier
affected
50% carriers + 50% affected
         
affected
clear
100%  carriers
         
affected
carrier
50% carriers + 50% affected
         
affected
affected
100% affected

 


Clear

Genotype: N / N [ Homozygous normal ]

The dog is noncarrier of the mutant gene.

It is very unlikely that the dog will develop Ichthyosis. The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.

 

Carrier

Genotype: N / ICH [ Heterozygous ]

The dog carries one copy of the mutant gene and one copy of the normal gene.

It is very unlikely that the dog will develop Ichthyosis but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%.

Carriers should only be bred to clear dogs.

Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)

 

Affected

Genotype: ICH / ICH [ Homozygous mutant ]

 

The dog carries two copies of the mutant gene and therefore it will pass the mutant gene to its entire offspring.

The dog is likely to develop Ichthyosis and will pass the mutant gene to its entire offspring
Sample Requirements
Whole blood in EDTA tube (0.5 - 1 ml) or Buccal Swabs.
Turnaround
1-2 weeks
Price for the above 15 tests
£ 150.00 (including VAT)

To order:




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See also:

 
 
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