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LABOKLIN (UK)| Genetic Diseases | Dogs| Bunny Hopping Syndrome (BHS1) / Spinal Dysraphism (SD) In mammals, the nerves from one half of the brain control the opposite half of the body. This means that nerves from the left half of the brain innervate the right half of the body and vice versa. For movement control to function correctly, nerve pathways in the spinal cord must only ever run on one side of the body. However, In dogs with BHS1, this strict order is disrupted and nerve pathways in the spinal cord switch sides. As a result, affected dogs cannot control either the left or the right hind leg, and always hop with both legs. Because this gait resembles the hopping of a bunny, the disease is called Bunny Hopping Syndrome. In contrast to Shaking-Puppy-Syndrome in Weimaraner dogs, the gait of BHS1-affected puppies does not improve as they grow based on current knowledge. Consequently, euthanasia is often considered as a result.

BHS1 has an autosomal recessive trait of inheritancehas an autosomal recessive trait of inheritance">
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Bunny Hopping Syndrome (BHS1) / Spinal Dysraphism (SD)

Test number: 8878
Gene: BHS1
Price: £ 48.00 (including VAT)
Breed
Weimaraner .
The Disease
The Bunny Hopping Syndrome (BHS1) / Spinal Dysraphism is an inherited disorder affecting the Weimaraner breed. The disease is characterized by the simultaneous movement or "bunny hopping" of the hind legs. Other signs include weakness and lack of coordination in the rear, while the front limbs remain coordinated and strong. Bunny hopping may occasionally be seen in the front legs. The disease is caused mutation which leads to malformations of the spinal cord during embryonic development.

In mammals, the nerves from one half of the brain control the opposite half of the body. This means that nerves from the left half of the brain innervate the right half of the body and vice versa. For movement control to function correctly, nerve pathways in the spinal cord must only ever run on one side of the body. However, In dogs with BHS1, this strict order is disrupted and nerve pathways in the spinal cord switch sides. As a result, affected dogs cannot control either the left or the right hind leg, and always hop with both legs. Because this gait resembles the hopping of a bunny, the disease is called Bunny Hopping Syndrome. In contrast to Shaking-Puppy-Syndrome in Weimaraner dogs, the gait of BHS1-affected puppies does not improve as they grow based on current knowledge. Consequently, euthanasia is often considered as a result.

Trait of Inheritance
BHS1 has an autosomal recessive trait of inheritancehas an autosomal recessive trait of inheritance

Inheritance : AUTOSOMAL RECESSIVE trait


 

Sire

 

Dam

 

Offspring

         
clear
clear
100% clear
         
clear
carrier
50%  clear + 50% carriers
         
clear
affected
100% carriers
         
carrier
clear
50%  clear + 50% carriers
         
carrier
carrier
25% clear + 25% affected + 50% carriers
         
carrier
affected
50% carriers + 50% affected
         
affected
clear
100%  carriers
         
affected
carrier
50% carriers + 50% affected
         
affected
affected
100% affected

 


Clear

Genotype: N / N [ Homozygous normal ]

The dog is noncarrier of the mutant gene.

It is very unlikely that the dog will develop Bunny Hopping Syndrome (BHS1) / Spinal Dysraphism (SD). The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.

 

Carrier

Genotype: N / BHS1 [ Heterozygous ]

The dog carries one copy of the mutant gene and one copy of the normal gene.

It is very unlikely that the dog will develop Bunny Hopping Syndrome (BHS1) / Spinal Dysraphism (SD) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%.

Carriers should only be bred to clear dogs.

Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)

 

Affected

Genotype: BHS1 / BHS1 [ Homozygous mutant ]

 

The dog carries two copies of the mutant gene and therefore it will pass the mutant gene to its entire offspring.

The dog is likely to develop Bunny Hopping Syndrome (BHS1) / Spinal Dysraphism (SD) and will pass the mutant gene to its entire offspring
Sample Requirements
Whole blood in EDTA tube (0.5 - 1 ml) or Buccal Swabs.
Price
£ 48.00 (including VAT)

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