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LABOKLIN (UK)| Genetic Diseases | Dogs| Deafness with Vestibular Dysfunction (DVD) / DINGS 1 and DINGS 2
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Deafness with Vestibular Dysfunction (DVD) / DINGS 1 and DINGS 2

Test number: 8875
Gene: DINGS 1 & DINGS 2
Price: £ 66.00 (including VAT)
Pllease note that DINGS2 is part of the KC DNA testing scheme in Doberman
Breed
Doberman Pinscher .
Kennel Club
DINGS2 is part of the Official UK Kennel Club DNA Testing Scheme in Doberman Pinscher.

for UK registered dogs, Laboklin can send results of the tests which are part of the Official UK Kennel Club DNA testing scheme to the Kennel Club (KC) to be recorded and published as part of the Kennel Club scheme. Results will only be recorded and published by the KC if the result report includes the dog’s microchip or tattoo number along with either the dog’s registered name or registered number. Any test results that do not carry these identifying features will not be recorded by the Kennel Club.

In order to ensure that test results are sent to the Kennel Club, customers must also sign the declaration section on the order form to give Laboklin permission to do so.

important: When you sign the declaration, Laboklin will send the results to the KC on your behalf, and you do not need to send them to the KC yourself again to avoid unnecessary duplications.

The Disease

Deafness with Vestibular Dysfunction (DVD) / DINGS 1 and DINGS 2

Doberman Pinschers can suffer from a neurological disorder known as DINGS, which can cause deafness and balance / coordination problems. This disorder is associated with variants in two different genes. One gene variant results in deafness in one ear, while the other causes deafness in both ears. This DNA test checks for two variants:
  • DINGS1: mutation in the PTPRQ gene, which is responsible for the unilateral form of deafness and vestibular response, and
  • DINGS2 : mutation in the MYO7A gene which is associated with the bilateral form of deafness and vestibular response.

DINGS is an inherited syndrome affecting the Doberman breed causing hearing loss and vestibular dysfunction. In Doberman, affected puppies exhibit symptoms of vestibular disease which include head tilt, circling and ataxia. Pathological findings in the inner ear included a progressive neuroepithelial type of cochlear degeneration characterized by a loss of the auditory sensory cells. Findings in the vestibular system included abnormal or absent otoconia in some of the affected dogs without sensory cell loss.

Trait of inheritance

both DINGS variants have autosomal recessive trait of inheritance. For each variant, two copies must be inherited (one from each parent) for the disease to occur, and both sexes are affected equally.
Sample Requirements
Whole blood in EDTA tube (0.5 - 1 ml) or Buccal Swabs
Turnaround
2-3 weeks
Price
£ 66.00 (including VAT)

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