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Congenital Hypothyroidism (CH)

Test number: 8873
Gene: CH
Price: £ 48.00 (including VAT)
Breed
All Cat Breeds .
The Disease

Congenital Hypothyroidism (CH)

Primary congenital hypothyroidism (CH) is an inherited disease affecting cats. The disease is caused by an impairment of the biosynthesis of hormones (dyshormonogenesis). Congenital Hypothyroidism in cats has similarities with the same disease in human.

Typical clinical signs in cats include disproportionate dwarfism, growth retardation and mental dullness. Thyroid blood tests show a combination of low concentrations of serum total thyroxine (T4) and high concentrations of thyroid-stimulating hormone (TSH). Other symptoms include the presence of a goitre, constipation, and delayed tooth eruption. Most affected cats have bilateral enlargement of both thyroid lobes, and, most, but not all, affected cats have a palpable goitre (presumably because of thyroid hyperplasia).

Affected cats are usually diagnosed as early as 6-8 weeks.

A variant in the TPO gene has been identified to be associated with symptoms of Congenital Hypothyroidism in cats. The variant has an autosomal recessive trait of inheritance.

The variant has so far been found in 15 breeds, namely the Balinese, Birman, British Longhair, British Shorthair, Chartreux, Domestic Shorthair, Domestic Medium Hair, Domestic Longhair, Exotic Shorthair, Main Coon, Norwegian Forest Cat, Oriental Shorthair, Russian Blue, Siberian, and Sphynx.

Trait of Inheritance
Autosomal recessive trait of inheritance

Inheritance : AUTOSOMAL RECESSIVE trait


 

Sire

 

Dam

 

Offspring

         
clear
clear
100% clear
         
clear
carrier
50%  clear + 50% carriers
         
clear
affected
100% carriers
         
carrier
clear
50%  clear + 50% carriers
         
carrier
carrier
25% clear + 25% affected + 50% carriers
         
carrier
affected
50% carriers + 50% affected
         
affected
clear
100%  carriers
         
affected
carrier
50% carriers + 50% affected
         
affected
affected
100% affected

 


Clear

Genotype: N / N [ Homozygous normal ]

The cat is noncarrier of the mutant gene.

It is very unlikely that the cat will develop Congenital Hypothyroidism (CH). The cat will never pass the mutation to its offspring, and therefore it can be bred to any other cat.

 

Carrier

Genotype: N / CH [ Heterozygous ]

The cat carries one copy of the mutant gene and one copy of the normal gene.

It is very unlikely that the cat will develop Congenital Hypothyroidism (CH) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%.

Carriers should only be bred to clear cats.

Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)

 

Affected

Genotype: CH / CH [ Homozygous mutant ]

 

The cat carries two copies of the mutant gene and therefore it will pass the mutant gene to its entire offspring.

The cat is likely to develop Congenital Hypothyroidism (CH) and will pass the mutant gene to its entire offspring
Sample Requirements
Whole blood in EDTA tube (0.5 - 1 ml) or Buccal Swabs.
Price
£ 48.00 (including VAT)

To order:




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