We apologize for any inconvenience caused by the internet outage in our area on Wednesday, 12th June 2024. Our website, email, and phone services were temporarily unavailable
between 9:30 am and 4:00 pm. We are pleased to inform you that the issue has been resolved, and all services are now back to normal. Thank you for your patience and understanding.


LABOKLIN (UK)| Genetic Diseases | Dogs| Shih Tzu DNA bundle (MTC, KLK, JPH2-PRA, DVL2)
prices in Pound
 
  Home
  News and offers
  Genetic Diseases
Dogs
Cats
Horses
Cattle
Pigs
Rabbit
Sheep
  Coat Colours / Length
  Identity / Parentage
  Reptiles & Amphibians
  Avian Tests
  Profiles / Screening
  Infectious Diseases
  Allergy testing
  Organs / Parameters
  Downloads & Order
  Order Kit Online
  About Us
  Crufts & Shows
  Contact Us
  Kennel Club ABS
  facebook
 
**NEW**



Maine Coon Special offer:
8 DNA tests for just £84.95 incl VAT
Maine Coon 8 DNA tests bundle (HCM, SMA, PKDef, Poly, b, b1, cb, cs) 
**NEW**



Bengal Special offer:
4 Bengal Specific DNA tests for just £72.00 incl VAT
Bengal DNA bundle (rdAc-PRA + b-PRA + PK-Def + Blood Groups) 



British Special offer:
4 Breed Specific DNA tests for just £72.00 incl VAT
British Short / Long Hair DNA bundle (PKD + pd-PRA + ALS + Blood Groups)



Burmese Special offer:
4 Breed Specific DNA tests for just £72.00 incl VAT
Burmese DNA bundle (Hypokalemia (BHK) + Head Defect + Gangliosidosis (GM2) + Blood Groups



Birman Special offer:
5 Breed Specific DNA tests for just £72.00 incl VAT
Birma DNA bundle (PKD + pd-PRA + Hypotrichiose + MPS6 + Blood Groups)



Maine Coon Special offer:
5 Breed Specific DNA tests for just £72.00 incl VAT
Maine Coon DNA bundle (HCM1 + SMA + PK-Def + F11 + Blood Groups)



Ragdoll Special offer:
5 Breed Specific DNA tests for just £72.00 incl VAT
Ragdoll DNA bundle (HCM1 + HCM3 + PKD + pd-PRA + Blood Groups)



Norwegian Special offer:
4 Breed Specific DNA tests for just £72.00 incl VAT
Norwegian Forest DNA bundle (PK-Def + Amber + GSD4 + Blood Groups)



Feline Special Offer:
8 cat DNA tests for just £84.95 including VAT
HCM, HCR, GSD4, PKD, PRA, PK-Def., SMA, Blood Groups

new test:      Paradoxical Pseudomyotonia (PP) in English Cocker and English Springer Spaniels  
new test:      Dyserythropoietic Anemia and Myopathy Syndrome (DAMS) in English Springer Spaniel
new test:      Lysosomal Storage Diseases (LSD) in Dalmatian and Doberman  
new Kennel Club DNA testing schemes with LABOKLIN:
   Osteochondrodysplasia (OCD) / Skeletal Dwarfism in Miniature Poodles
  DINGS2: Deafness with Vestibular Dysfunction in Doberman
   Dyserythropoietic Anemia and Myopathy Syndrome (DAMS) in English Springer Spaniel


Shih Tzu DNA bundle (MTC, KLK, JPH2-PRA, DVL2)

Test number: 8835

Price: £ 132.00 (including VAT) for all 4 tests

  1 ) Macrothrombocytopenia ( MTC-D )

Breeds
American Cocker Spaniel , Bichon Frise , Boxer , Cavalier King Charles Spaniel , Cavapoo , Chihuahua , Cocker Spaniel , Dwarf poodle , English Cocker Spaniel , Havanese - Bichon Havanese , Jack Russell Terrier , Labrador Retriever , Maltese , Miniature Poodle , Parson Russell Terrier (PRT) , Poodle , Shih Tzu , Standard Poodle , Toy Poodle .
Trait of Inheritance
.

Inheritance : AUTOSOMAL DOMINANT trait
Description

Macrothrombocytopenia ( MTC ) is inherited as an autosomal dominant trait characterized by low platelet count and the presence of some larger than normal platelets in circulation.

Unlike acquired macrothrombocytopenia (thrombocytopenias secondary to infectious agents, medications, immune-mediated causes), this form does not respond to treatment.

It is important to note that these dogs may mistakenly be considered to have an underlying disease that results in thrombocytopenia, such as immune-mediated thrombocytopenia, tick-borne infection, or a bone marrow disorder.

TC ) is inherited as an autosomal dominant trait and results can be Clear (N/N), Affected heterozygous (N / MTC), Affected homozygous (MTC / MTC)

A RECESSIVE form of MTC is found in other breeds click on the following link for further details: Recessive Macrothrombocytopenia (MTC) .

 
Further reading
Macrothrombocytopenia in a Cavalier King Charles SpanielPDF file
Sample Requirements
Whole blood in EDTA tube (0.5 - 1 ml) or Buccal Swabs.
Turnaround
2 - 3 weeks

  2 ) Prekallikrein Deficiency (KTK) / Fletcher Factor Deficiency

Breed
Shih Tzu .
The Disease
Prekallikrein deficiency (Fletcher Trait) is rare inherited autosomal recessive bleeding disorder characterized by slow healing, abnormal bleeding following surgeries and sometimes excessive gastrointestinal bleeding or presence of blood in the urine.
Trait of Inheritance
.

Inheritance : AUTOSOMAL RECESSIVE trait


 

Sire

 

Dam

 

Offspring

         
clear
clear
100% clear
         
clear
carrier
50%  clear + 50% carriers
         
clear
affected
100% carriers
         
carrier
clear
50%  clear + 50% carriers
         
carrier
carrier
25% clear + 25% affected + 50% carriers
         
carrier
affected
50% carriers + 50% affected
         
affected
clear
100%  carriers
         
affected
carrier
50% carriers + 50% affected
         
affected
affected
100% affected

 


Clear

Genotype: N / N [ Homozygous normal ]

The dog is noncarrier of the mutant gene.

It is very unlikely that the dog will develop Prekallikrein Deficiency (KTK) / Fletcher Factor Deficiency. The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.

 

Carrier

Genotype: N / KTK [ Heterozygous ]

The dog carries one copy of the mutant gene and one copy of the normal gene.

It is very unlikely that the dog will develop Prekallikrein Deficiency (KTK) / Fletcher Factor Deficiency but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%.

Carriers should only be bred to clear dogs.

Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)

 

Affected

Genotype: KTK / KTK [ Homozygous mutant ]

 

The dog carries two copies of the mutant gene and therefore it will pass the mutant gene to its entire offspring.

The dog is likely to develop Prekallikrein Deficiency (KTK) / Fletcher Factor Deficiency and will pass the mutant gene to its entire offspring
Sample Requirements
Whole blood in EDTA tube (0.5 - 1 ml) or Buccal Swabs.
Turnaround
2 - 3 weeks

  3 ) Progressive Retinal Atrophy (JPH2 - PRA )in Shih Tzu

Breed
Shih Tzu .
The Disease
Progressive retinal atrophy (PRA), common autosomal recessive disorder affecting several dog breeds including Shih Tzu, is characterized by degeneration of photoreceptors leading to blindness. A mutation in the JPH2 gene has been identified to be responsible for PRA in the Shih Tzu breed and the test is now available at Laboklin.
Trait of Inheritance
Autosomal recessive trait

Inheritance : AUTOSOMAL RECESSIVE trait


 

Sire

 

Dam

 

Offspring

         
clear
clear
100% clear
         
clear
carrier
50%  clear + 50% carriers
         
clear
affected
100% carriers
         
carrier
clear
50%  clear + 50% carriers
         
carrier
carrier
25% clear + 25% affected + 50% carriers
         
carrier
affected
50% carriers + 50% affected
         
affected
clear
100%  carriers
         
affected
carrier
50% carriers + 50% affected
         
affected
affected
100% affected

 


Clear

Genotype: N / N [ Homozygous normal ]

The dog is noncarrier of the mutant gene.

It is very unlikely that the dog will develop Progressive Retinal Atrophy (JPH2 - PRA )in Shih Tzu. The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.

 

Carrier

Genotype: N / JPH2 [ Heterozygous ]

The dog carries one copy of the mutant gene and one copy of the normal gene.

It is very unlikely that the dog will develop Progressive Retinal Atrophy (JPH2 - PRA )in Shih Tzu but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%.

Carriers should only be bred to clear dogs.

Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)

 

Affected

Genotype: JPH2 / JPH2 [ Homozygous mutant ]

 

The dog carries two copies of the mutant gene and therefore it will pass the mutant gene to its entire offspring.

The dog is likely to develop Progressive Retinal Atrophy (JPH2 - PRA )in Shih Tzu and will pass the mutant gene to its entire offspring
Sample Requirements
Whole blood in EDTA tube (0.5 - 1 ml) or Buccal Swabs.
Turnaround
1-3 weeks

  4 ) Robinow-like Syndrome ( DVL2 )

Breeds
All Dog Breeds , American Bulldog , American Pitbull Terrier , American Staffordshire Terrier , Boston Terrier , Bulldog (English) , Continental Bulldog , Dogue de Bordeaux (French Mastiff) , French Bull Dog , Olde English Bulldogge , Shih Tzu , Staffordshire Bull Terrier .
The Disease

Robinow-like-Syndrome (DVL2)

With their small size, stubby faces and wide-set eyes, bulldogs, French bulldogs and Boston terriers are among the most popular of domestic dog breeds. Now researchers at the University of California, Davis, School of Veterinary Medicine have found the genetic basis for these dogs’ appearance, and linked it to a rare inherited syndrome in humans.

Genetic variants of the Dishevelled 1 (DVL1) and 3 (DVL3) genes cause the so-called Robinow syndrome in humans , which can be characterized by distinctive facial features (prominent forehead, widely spaced eyes, flat nasal bridge) as well as mesomelic limb shortening (middle parts of limbs are disproportionately short) and cardiac, oral and urogenital anomalies.

English Bulldogs, French Bulldogs and Boston Terriers

In English Bulldogs, French Bulldogs and Boston Terriers, a variant of the DVL2 gene has been found to be fixed (always homozygous for the variant DVL/DVL). This genetic variant leads to altering a protein that affects an important cell-to-cell communication system, which is crucial for tissue development.

The typical phenotype of these breeds includes a wide head, a short muzzle (brachycephaly), widely spaced eyes and a small size. Malformed, fused or lacking caudal vertebrae which leads to truncated and kinked tails, so that the breeds are also called screw tail breeds.

In these three breeds, the DVL2 variant has been found to segregate with the breed defining phenotype as well as thoracic and caudal vertebral malformations in a recessive manner, however, regarding to the thoracic vertebral malformations, the variant seems to have an incomplete and variable penetrance between different breeds. Moreover, the DVL2 variant contributes to the brachycephalic phenotype, in addition to other known genetic variants of the SMCO2 and BMP3 gene. The DVL2 variant could also be linked to other health concerns like the brachycephalic obstructive airway syndrome (BOAS) and congenital heart defects, but this is still part of ongoing research.

In other none-screw tail breeds

Beside the screw tail breeds, the DVL2 variant has also been found homo- or heterozygous in the Pit bull, Staffordshire Bull Terrier, Shih Tzu, American Staffordshire Terrier, Dogues de Bordeaux, Old English Bulldog and American Bulldog. In these breeds, the DVL2 variant seems to be associated with a brachycephalic phenotype and caudal vertebral malformations as well. However, in contrast to the screw tail breeds, the total number of the vertebrae is not reduced and the tail is not completely malformed. Furthermore, no thoracic vertebral malformations have been observed, perhaps due to the variable penetrance of this trait.
Sample Requirements
Whole blood in EDTA tube (0.5 - 1 ml) or Buccal Swabs.
Turnaround
1-3 weeks
Price for the above 4 tests
£ 132.00 (including VAT)

To order:




new test:
Androgen Insensitivity Syndrome (AIS)
new test:
ACAN Dwarfism (Chondrodysplasia)
new test:
Predictive Height Test ( LCORL)
new test:

Tractability
new test:
Coat colour Sunshire Dilution



See also:

 
 
Home   |   Genetic Diseases  |   Coat Colours / Length  |   Identity / Parentage  |   Reptiles & Amphibians  |   Avian Tests  |   Profiles / Screening  |   Infectious Diseases  |   Allergy testing  |   Organs / Parameters  |   About us  |   Contact Us
LABOKLIN GmbH & Co. KG
ISO / DIN 17025 Accredited Laboratory
© 2007-2023 Laboklin (UK)
Unit 20, Wheel Forge Way, Trafford Park, Manchester, M17 1EH
Tel. 0161 282 3066