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Skeletal Dysplasia
Test number: 8808
Gene: SD Price: £ 48.00 (including VAT)
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Breeds
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British Shorthair (BSH)
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Scottish Fold Longhair
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Scottish Fold Shorthair
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The Disease |
In the breed British Shorthair, a mutation in the gene LTBP3 was found to cause skeletal dysplasia. First symptoms like hind limb paraparesis were already shown at the age of 8 weeks in affected kittens. Further symptoms like lordosis and scoliosis, myelopathy and reduced motility of the intestine were shown at the age of 10 weeks. A deformation of the vertebral column was seen in radiological examination. Affected kittens showed deteriorating paraparesis, deformation of multiple thoracic vertebral bodies, stenosis of the vertebral canal, compression of the spinal cord tissue and coprostasis. Due to the severity of symptoms, the affected kittens were euthanized.
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Trait of Inheritance |
Autosomal recessive mode of inheritance
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Inheritance : AUTOSOMAL
RECESSIVE
trait
Sire
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Dam
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Offspring
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clear
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clear
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100% clear
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clear
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carrier
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50% clear + 50%
carriers
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clear
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affected
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100% carriers
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carrier
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clear
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50% clear + 50%
carriers
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carrier
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carrier
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25% clear + 25% affected
+ 50% carriers
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carrier
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affected
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50% carriers + 50%
affected
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affected
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clear
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100% carriers
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affected
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carrier
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50% carriers + 50%
affected
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affected
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affected
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100% affected
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Clear
Genotype: N / N [ Homozygous normal ]
The cat is noncarrier of the mutant gene.
It is very unlikely that the cat will develop Skeletal Dysplasia. The cat will never pass the mutation to its offspring, and therefore it can be bred to any other cat.
Carrier
Genotype: N / SD [ Heterozygous ]
The cat carries one copy of the mutant gene and one
copy of the normal gene.
It is very unlikely that the cat will develop Skeletal Dysplasia but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%. Carriers should only be bred to clear cats. Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)
Affected
Genotype: SD / SD [ Homozygous mutant ]
The cat carries two copies of the mutant gene and
therefore it will pass the mutant gene to its entire offspring.
The cat is likely to develop Skeletal Dysplasia and will pass the mutant gene to its entire offspring
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Price
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£ 48.00 (including VAT)
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See also: |
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HCM 1 (Hypertrophic Cardiomyopathy)
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HCM4 ( Hypertrophic Cardiomyopathy HCM 4) in Sphynx
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HCM (Hypertrophic Cardiomyopathy HCM3/HCR)
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PKD (Feline Polycystic Kidney Disease)
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PK Deficiency (Pyruvate Kinase Deficiency)
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rdAc-PRA (Progressive Retinal Atrophy )
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SMA (Spinal Muscular Atrophy )
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Serological Evaluation of blood Groups
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Hypokalemia / Familial Episodic Hypokalaemic Polymyopathy (BHK)
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Head Defect (BHD)
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Alpha-Mannosidosis (AMD)
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Congenital Myasthenic Syndrome (CMS) / Hereditary Myopathy
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Gangliosidosis GM1
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Gangliosidosis GM2
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Gangliosidosis GM2
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Mucopolysaccharidosis Type VI (MPS VI MPS6)
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Mucopolysaccharidosis type VII (MPS VII / MPS7)
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Myotonia Congenita (Fainting Goat)
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pd - Progressive Retinal Atrophy (pd-PRA)
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Progressive Retinal Atrophy (rdy-PRA)
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Hypotrichosis and Short Life Expectancy
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Progressive Retinal Atrophy in Bengal (PRA-b / b-PRA)
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Special Offer: HCM, HCR, GSD4, PKD, PRA, PK-Def., SMA, Blood Groups
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Osteochondrodysplasia (Scottish Fold Osteodystrophy)
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Primary Congenital Glaucoma (PCG)
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Cystinuria (Feline Cystinuria) (CY)
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Persian DNA bundle (PKD + pd-PRA + AMD + Blood Groups)
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British Short / Long Hair DNA bundle (PKD + pd-PRA + ALPS + Blood Groups)
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Burmese DNA bundle (Hypokalemia (BHK) + Head Defect + Gangliosidosis (GM2) + Blood Groups
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Birma DNA bundle (PKD + pd-PRA + Hypotrichiose + MPS6 + Blood Groups)
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Bengal DNA bundle (rdAc-PRA + b-PRA + PK-Def + Blood groups)
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Maine Coon DNA bundle (HCM1 + SMA + PK-Def + FXI + Blood Groups)
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Ragdoll DNA bundle (HCM1 + HCM3 + PKD + pd-PRA + Blood groups)
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Norwegian Forest DNA bundle (PK-Def + Amber + GSD4 + Blood groups)
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Siamese / Oriental DNA bundle (GM1 + MPS6 + PCG + rdAc-PRA + Blood Groups)
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Sphynx DNA bundle (HCM4 + Hypokalemia + CMS + Blood groups)
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Acrodermatitis enteropathica in Felis catus
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Factor XI deficiency ( F11 )
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MDR1 Gene Defect
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Factor 12 FXII cat
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Devon Rex DNA bundle (CMS + Blood Groups + Long Coat + Rex Hair)
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Siberian DNA Bundle (Blood Groups + PK-Def + Dilution + Colourpoint)
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Genetic Blood groups in cats
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LABOGenetics XXL Cat - Comprehensive Feline DNA bundle
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Autoimmune Lymphoproliferative Syndrome (ALPS)
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Polydactyly (extra toes) / polydactylism / Polydactyl / hyperdactyly
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Unlisted DNA test
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Congenital Hypothyroidism (CH)
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Maine Coon 8 DNA tests bundle (HCM, SMA, PKDef, Poly, b, b1, cb, cs)
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Blue Eyes
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Glycogen Storage Disease ( GSD ) Type IV
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