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**NEW**



Bengal Special offer:
3 Bengal Specific DNA tests for just £60.00 incl VAT
Bengal DNA bundle (rdAc-PRA + b-PRA + PK-Def) 



British Special offer:
3 Breed Specific DNA tests for just £60.00 incl VAT
British Short / Long Hair DNA bundle (PKD + pd-PRA + ALS)



Burmese Special offer:
3 Breed Specific DNA tests for just £66.00 incl VAT
Burmese DNA bundle (Hypokalemia (BHK) + Head Defect + Gangliosidosis (GM2)



Birman Special offer:
4 Breed Specific DNA tests for just £66.00 incl VAT
Birma DNA bundle (PKD + pd-PRA + Hypotrichiose + MPS6)



Maine Coon Special offer:
3 Breed Specific DNA tests for just £60.00 incl VAT
Maine Coon DNA bundle (HCM1 + SMA + PK-Def)



Ragdoll Special offer:
4 Breed Specific DNA tests for just £60.00 incl VAT
Ragdoll DNA bundle (HCM1 + HCM3 + PKD + pd-PRA)



Norwegian Special offer:
3 Breed Specific DNA tests for just £60.00 incl VAT
Norwegian Forest DNA bundle (PK-Def + Amber + GSD4)



Feline Special Offer:
8 cat DNA tests for just £79.95 including VAT
HCM, HCR, GSD4, PKD, PRA, PK-Def., SMA, Blood Groups

new test: Cocoa (Chocolate / Brown ) in French Bulldog
new test: Stargardt disease ( STGD )  and  Copper storage disease - Copper toxicosis (CT) in Labrador Retriever
new test: Inflammatory Pulmonary Disease ( IPD ) in Rough and Smooth Collies
new test: Lafora Disease in Basset Hound, Beagle, Chihuahua, French Bulldog, Welsh Corgi and Mini Wirehaired Dachshund
new Kennel Club DNA testing schemes with LABOKLIN:
• Pug Dog Encephalitis (PDE) / Necrotizing Meningoencephalitis (NME) in Pug
• Progressive Retinal Atrophy (prcd-PRA) and • Progressive retinal atrophy ( rcd4-PRA) / LOPRA in Standard Poodle
• Dwarfism ( Chondrodysplasia / disproportinate short-limbed ) and • Primary Open Angle Glaucoma (POAG) in Norwegian Elkhounds


MDR1 Gene Defect

Test number: 8776
Gene: MDR1
Price: £ 48.00 (including VAT)
Breeds
Angora , Balinese , Domestic Shorthair , Maine Coon , Ragdoll , Russian Blue , Siamese .
The Disease

MDR1 Gene Defect / Multidrug resistance 1 syndrome

Test can detect deadly genetic mutation in cats

A new test developed by Washington State University researchers can detect a rare genetic mutation in cats that can cause potentially deadly reactions to some common medications, including those used to control parasites and in routine surgical procedures, like spays and neuters.

The only way to tell if a cat has the mutation, which is found in about 4% of all cats, is through a genetic test, which is available to pet owners and vets at Laboklin.

The test was developed by Dr Katrina Mealey, who, along with her team set up 'Program in Individualized Medicine (PrIMe)' at WSU's College of Veterinary Medicine have been working to develop the test and identify drugs that may be toxic to affected cats since 2014 when they discovered the mutation, which occurs in the MDR1 (multidrug resistance 1) gene, also known as the ABCB1 gene. The gene plays an important role in limiting drug distribution to the brain and in enhancing the excretion of many drugs.

Katrina Mealey is also responsible for the initial discovery of the MDR1 mutation in dogs in 2001 and for leading the development at WSU of the first commercial tests for canines.

'The mutation is probably about as common in cats as it is dogs, except that in dogs we know it is more breed specific,' Mealey said. 'So, if you have a collie, we know the animal has a 75% chance of having the mutation. In cats, though, it seems to be widely distributed and not breed specific.'

 
Further reading
How Should I Treat Dogs & Cats with MDR1 Mutation?PDF file
Sample Requirements
Whole blood in EDTA tube (0.5 - 1 ml) or Buccal Swabs.
Whole blood in EDTA tube (0.5 - 1 ml) or Buccal swabs. .
Turnaround
2-3 weeks
Price
£ 48.00 (including VAT)

To order:

  • Download Order Form from this link pdf

  • Complete the order form and send it together with your samples to the following address:

    Laboklin (UK),   125 Northenden Road, Manchester, M33 3HF




new test:
Androgen Insensitivity Syndrome (AIS)
new test:
ACAN Dwarfism (Chondrodysplasia)
new test:
Predictive Height Test ( LCORL)
new test:

Tractability
new test:
Coat colour Sunshire Dilution



See also:
HCM 1 (Hypertrophic cardiomyopathy ) Mutation Meurs (G-- > C) A31P  
HCM (Hypertrophic Cardiomyopathy HCM3/HCR)  
PKD (Feline Polycystic Kidney Disease)  
PK Deficiency (Pyruvate Kinase Deficiency)  
rdAc-PRA (Progressive Retinal Atrophy )  
Genetic Blood groups in cats  
SMA (Spinal Muscular Atrophy )  
Serological Evaluation of blood Groups  
Hypokalemia / Familial Episodic Hypokalaemic Polymyopathy (BHK)  
Head Defect (BHD)  
Alpha-Mannosidosis (AMD)  
Congenital Myasthenic Syndrome (CMS)  
Gangliosidosis GM1  
Gangliosidosis GM2  
Gangliosidosis GM2  
Mucopolysaccharidosis Type VI (MPS VI MPS6)  
Mucopolysaccharidosis type VII (MPS VII / MPS7)  
Myotonia Congenita (Fainting Goat)  
pd - Progressive Retinal Atrophy (pd-PRA)  
Progressive Retinal Atrophy (rdy-PRA)  
Hypotrichosis and Short Life Expectancy  
Progressive Retinal Atrophy in Bengal (PRA-b / b-PRA)  
Special Offer: HCM, HCR, GSD4, PKD, PRA, PK-Def., SMA, Blood Groups  
Osteochondrodysplasia (Scottish Fold Osteodystrophy)  
Primary Congenital Glaucoma (PCG)  
Autoimmune Lymphoproliferative Syndrome (ALPS)  
Cystinuria (Feline Cystinuria) (CY)  
Persian DNA bundle (PKD + pd-PRA + AMD)  
British Short / Long Hair DNA bundle (PKD + pd-PRA + ALPS)  
Burmese DNA bundle (Hypokalemia (BHK) + Head Defect + Gangliosidosis (GM2)  
Birma DNA bundle (PKD + pd-PRA + Hypotrichiose + MPS6)  
Bengal DNA bundle (rdAc-PRA + b-PRA + PK-Def)  
Maine Coon DNA bundle (HCM1 + SMA + PK-Def)  
Ragdoll DNA bundle (HCM1 + HCM3 + PKD + pd-PRA)  
Norwegian Forest DNA bundle (PK-Def + Amber + GSD4)  
Siamese / Oriental DNA bundle (GM1 + MPS6 + PCG + rdAc-PRA)  
Sphynx DNA bundle (Bloodgroups + Hypokalemia + CMS)  
HCM4 ( Hypertrophic Cardiomyopathy HCM 4) in Sphynx  
Acrodermatitis enteropathica in Felis catus  
Factor XI deficiency ( F11 )  
Glycogen Storage Disease ( GSD ) Type IV  

 
 
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LABOKLIN GmbH & Co. KG
ISO / DIN 17025 Accredited Laboratory
© 2007 Laboklin (UK)
125 Northenden Road, Manchester, M33 3HF
Tel. 0161 282 3066