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new tests:
new
Kennel Club
DNA testing schemes with LABOKLIN:
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Progressive retinal atrophy ( PRA3 ) in Tibetan Terrier & Tibetan Spaniel
Test number: 8767
Gene Name: PRA3
Short Name: PRA3
Price: £ 48.00 (including VAT)
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Breeds
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Tibet Spaniel
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Tibetan Terrier
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Kennel Club
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This test is part of the Official UK Kennel Club DNA Testing Scheme in Tibet Spaniel, and Tibetan Terrier.
for UK registered dogs, Laboklin can send results of the tests which are part of the Official UK Kennel Club DNA testing scheme to the Kennel Club (KC) to be recorded and published
as part of the Kennel Club scheme. Results will only be recorded and published by the KC if the result report includes the dog’s
microchip or tattoo number along with either the dog’s registered name or registered number. Any test results that do not carry these identifying
features will not be recorded by the Kennel Club.
In order to ensure that test results are sent to the Kennel Club, customers must also sign the declaration section on the order form to give Laboklin permission to do so.
important:
When you sign the declaration, Laboklin will send the results to the KC on your behalf, and you do not need to send them to the KC yourself again to avoid unnecessary duplications.
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The Disease |
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Progressive retinal Atrophy ( PRA3 ) is an inherited eye disease affecting Tibetan spaniel and Tibetan Terrier breed. PRA3 is a progressive disease with late onset of symptoms. The disease is characterised by degeneration of both rod and cone photoceptors. Degeneration of rod receptors leads to night blindness and loss of peripheral vision, whereas degeneration of cone photoreceptors results in loss of central vision and eventually complete blindness.
Most PRA cases in the Tibetan Spaniel (TS) are clinically indistinguishable from other forms of PRA. The mode of inheritance appears from pedigree information to be autosomal recessive and the age of diagnosis is relatively late, typically at approximately 5 years of age [19]. No mutations have previously been associated with PRA in the breed.
Although the reported average age of clinical diagnosis in dogs affected with PRA3 is about 4.5-5 years of age, many breeders may delay screening their dogs until they notice obvious signs that their dog has visual problems, by which point the disease is often advanced. It is therefore possible, if not highly likely, that the age of onset of PRA3 is much earlier than the estimated 4.5-5 years. |
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Trait of Inheritance |
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Autosomal recessive
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Inheritance : AUTOSOMAL
RECESSIVE
trait
Sire
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Dam
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Offspring
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clear
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clear
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100% clear
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clear
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carrier
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50% clear + 50%
carriers
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clear
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affected
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100% carriers
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carrier
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clear
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50% clear + 50%
carriers
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carrier
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carrier
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25% clear + 25% affected
+ 50% carriers
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carrier
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affected
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50% carriers + 50%
affected
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affected
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clear
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100% carriers
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affected
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carrier
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50% carriers + 50%
affected
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affected
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affected
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100% affected
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Clear
Genotype: N / N [ Homozygous normal ]
The dog is noncarrier of the mutant gene.
It is very unlikely that the dog will develop Progressive retinal atrophy ( PRA3 ) in Tibetan Terrier & Tibetan Spaniel. The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.
Carrier
Genotype: N / PRA3 [ Heterozygous ]
The dog carries one copy of the mutant gene and one
copy of the normal gene.
It is very unlikely that the dog will develop Progressive retinal atrophy ( PRA3 ) in Tibetan Terrier & Tibetan Spaniel but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%. Carriers should only be bred to clear dogs. Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)
Affected
Genotype: PRA3 / PRA3 [ Homozygous mutant ]
The dog carries two copies of the mutant gene and
therefore it will pass the mutant gene to its entire offspring.
The dog is likely to develop Progressive retinal atrophy ( PRA3 ) in Tibetan Terrier & Tibetan Spaniel and will pass the mutant gene to its entire offspring
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Price
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£ 48.00 (including VAT)
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| See also: |
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