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Ichthyosis type 2

Test number: 8738
Gene: Ichthyosis
Price: £ 48.00 (including VAT)
Breeds
Golden Retriever , Goldendoodle .
The Disease
Ichthyosis type 2 is another variant which causes Ichthyosis in Golden Retriever, this test helps in explaining cases which was tested negative for the already known Ichrthyosis variant. Ichthyosis is a genetic disease causing dysfunction of the keratin in the skin, which leads to the production of large, differently pigmented skin scales. Due to the fish-like look of this scales the name was formed from the Greek word for fish: „Ichthýs“. Additionally, the pigmentation of the skin can be altered.

Dogs which are affected by this dermatosis develop first symptoms soon after birth. Unfortunately, there is no treatment for this disease. In some cases, formation of scales decreases in old dogs.

Please note that there is another form of Ichthyosis affecting the golden retriever breed, Ichthyosis or Ichthyosis Type 1, click here for more details. you need both tests for complete analysis

Trait of Inheritance
Autosomal recessive

Inheritance : AUTOSOMAL RECESSIVE trait


 

Sire

 

Dam

 

Offspring

         
clear
clear
100% clear
         
clear
carrier
50%  clear + 50% carriers
         
clear
affected
100% carriers
         
carrier
clear
50%  clear + 50% carriers
         
carrier
carrier
25% clear + 25% affected + 50% carriers
         
carrier
affected
50% carriers + 50% affected
         
affected
clear
100%  carriers
         
affected
carrier
50% carriers + 50% affected
         
affected
affected
100% affected

 


Clear

Genotype: N / N [ Homozygous normal ]

The dog is noncarrier of the mutant gene.

It is very unlikely that the dog will develop Ichthyosis type 2. The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.

 

Carrier

Genotype: N / Ichthyosis [ Heterozygous ]

The dog carries one copy of the mutant gene and one copy of the normal gene.

It is very unlikely that the dog will develop Ichthyosis type 2 but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%.

Carriers should only be bred to clear dogs.

Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)

 

Affected

Genotype: Ichthyosis / Ichthyosis [ Homozygous mutant ]

 

The dog carries two copies of the mutant gene and therefore it will pass the mutant gene to its entire offspring.

The dog is likely to develop Ichthyosis type 2 and will pass the mutant gene to its entire offspring
Sample Requirements
Whole blood in EDTA tube (0.5 - 1 ml) or Buccal Swabs.
Turnaround
1 - 3 weeks
Price
£ 48.00 (including VAT)

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