LABOKLIN (UK)| Genetic Diseases | Cats| Factor XI deficiency ( F11 )

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Factor XI deficiency ( F11 ) Test number: 8729 Gene: F11 Price: £ 48.00 (including VAT)

Breed

Maine Coon .

The Disease

Coagulation factor XI is a plasma protein which is involved in the intrinsic blood coagulation cascade. In contrast to haemophilia, bleeding tendency in factor XI deficiency is only slightly increased. Haematomas and other minor bleeding are typical which only occur sometimes after trauma or surgery. Factor XI deficiency prolongs the partial thromboplastin time in plasma, but the prothrombin time remains normal.

LABOKLIN has studied Maine Coon cats with an increased bleeding tendency as well as their relatives and identified a genetic defect in factor XI. This has also led to the detection of homozygous affected cats as well as carriers in Europe. Factor XI deficiency is inherited in an autosomal recessive manner. This genetic test can be used to reliably identify Maine Coon cats with an increased risk of bleeding, but also asymptomatic male and female carriers, and thus limit the transmission of this genetic defect in breeding.

Trait of Inheritance

Autosomal recessive trait of inheritance

Inheritance : AUTOSOMAL RECESSIVE trait

Sire	Dam	Offspring

clear	clear	100% clear

clear	carrier	50% clear + 50% carriers

clear	affected	100% carriers

carrier	clear	50% clear + 50% carriers

carrier	carrier	25% clear + 25% affected + 50% carriers

carrier	affected	50% carriers + 50% affected

affected	clear	100% carriers

affected	carrier	50% carriers + 50% affected

affected	affected	100% affected

Clear

Genotype: N / N [ Homozygous normal ]

The cat is noncarrier of the mutant gene.
It is very unlikely that the cat will develop Factor XI deficiency ( F11 ). The cat will never pass the mutation to its offspring, and therefore it can be bred to any other cat.

Carrier

Genotype: N / F11 [ Heterozygous ]

The cat carries one copy of the mutant gene and one copy of the normal gene.
It is very unlikely that the cat will develop Factor XI deficiency ( F11 ) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%.
Carriers should only be bred to clear cats.
Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)

Affected

Genotype: F11 / F11 [ Homozygous mutant ]

The cat carries two copies of the mutant gene and therefore it will pass the mutant gene to its entire offspring.
The cat is likely to develop Factor XI deficiency ( F11 ) and will pass the mutant gene to its entire offspring

Sample Requirements

Buccal Swabs or 0.5 - 1 ml blood in EDTA Blood Tube

Turnaround

1-3 weeks

Price

£ 48.00 (including VAT)

To order:

Download Order Form from this link
Complete the order form and send it together with your samples to the following address:
Laboklin (UK), Unit 20, Wheel Forge Way, Trafford Park, Manchester, M17 1EH
Buccal swabs and EDTA tubes are available from us free of charge, to order, please use the online form <Request sample collection materials> or email: info@laboklin.co.uk.
If you are sending swab samples, please follow the instructions on this link .

If you have any queries, please contact us on 0161 282 3066

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Sire

Dam

Offspring