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LABOKLIN (UK)| Genetic Diseases | Dogs| Laryngeal Paralysis - Polyneuropathy ( LPPN3 )
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Laryngeal Paralysis - Polyneuropathy ( LPPN3 )

Test number: 8685
Gene: LPPN3
Price: £ 48.00 (including VAT)
Breeds
Labrador Retriever , Leonberger , St. Bernard .
Kennel Club
This test is part of the Official UK Kennel Club DNA Testing Scheme in Leonberger.

for UK registered dogs, Laboklin can send results of the tests which are part of the Official UK Kennel Club DNA testing scheme to the Kennel Club (KC) to be recorded and published as part of the Kennel Club scheme. Results will only be recorded and published by the KC if the result report includes the dog’s microchip or tattoo number along with either the dog’s registered name or registered number. Any test results that do not carry these identifying features will not be recorded by the Kennel Club.

In order to ensure that test results are sent to the Kennel Club, customers must also sign the declaration section on the order form to give Laboklin permission to do so.

important: When you sign the declaration, Laboklin will send the results to the KC on your behalf, and you do not need to send them to the KC yourself again to avoid unnecessary duplications.

The Disease
The LPPN3 is another mutation that causes Laryngeal Paralysis - Polyneuropathy in Leonberger. It has also been found in Labrador Saint Bernard. Affected leonberger puppies usually develop severe symptoms of laryngeal paralysis at young age including breathing difficulty which is often loud and gagging, difficulty in swallowing food, hanges in barking frequency and quality, high-stepping and uncoordinated gait, stumbling and tripping, exercise intolerance, and muscle atrophy. In Leonberger there two more mutations known to cause the disease LPN1 and LPN2, the three tests are recommended for complete diagnosis:
Trait of Inheritance
LPPN3 is inherited in autosomal recessitive mode which means that two copies of the mutation are required for the dog to develop symptoms of the disease

Inheritance : AUTOSOMAL RECESSIVE trait


 

Sire

 

Dam

 

Offspring

         
clear
clear
100% clear
         
clear
carrier
50%  clear + 50% carriers
         
clear
affected
100% carriers
         
carrier
clear
50%  clear + 50% carriers
         
carrier
carrier
25% clear + 25% affected + 50% carriers
         
carrier
affected
50% carriers + 50% affected
         
affected
clear
100%  carriers
         
affected
carrier
50% carriers + 50% affected
         
affected
affected
100% affected

 


Clear

Genotype: N / N [ Homozygous normal ]

The dog is noncarrier of the mutant gene.

It is very unlikely that the dog will develop Laryngeal Paralysis - Polyneuropathy ( LPPN3 ). The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.

 

Carrier

Genotype: N / LPPN3 [ Heterozygous ]

The dog carries one copy of the mutant gene and one copy of the normal gene.

It is very unlikely that the dog will develop Laryngeal Paralysis - Polyneuropathy ( LPPN3 ) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%.

Carriers should only be bred to clear dogs.

Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)

 

Affected

Genotype: LPPN3 / LPPN3 [ Homozygous mutant ]

 

The dog carries two copies of the mutant gene and therefore it will pass the mutant gene to its entire offspring.

The dog is likely to develop Laryngeal Paralysis - Polyneuropathy ( LPPN3 ) and will pass the mutant gene to its entire offspring
Sample Requirements
Whole blood in EDTA tube (0.5 - 1 ml) or Buccal Swabs.
Turnaround
2-3 weeks
Price
£ 48.00 (including VAT)

To order:




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