Shar-Pei Autoinflammatory Disease (SPAID)
SPAID is a breed-specific syndrome linked to a genetic predisposition for chronic inflammation. Affected Shar-Pei dogs may experience symptoms such as:
- Fever
- Arthritis
- Dermatitis
- Otitis (ear infections)
- Systemic amyloidosis
- Erythema in skin folds
- Thickened, pasty skin
- Eye inflammation
- Recurrent intestinal issues
Symptoms typically appear between the ages of 1 to 6 years and vary in severity. SPAID is strongly associated with a mutation in the MTBP gene, which impacts inflammatory pathways. Based on genetic testing, Shar-Pei dogs fall into three classifications:
- N/N (Normal): No detected SPAID mutation; low risk of developing autoinflammatory symptoms.
- N/SPAID (Carrier): One copy of the SPAID-associated mutation; increased risk of mild to moderate inflammatory signs.
- SPAID/SPAID (Affected): Two copies of the mutation; high likelihood of severe autoinflammatory symptoms, including Shar-Pei Fever and systemic amyloidosis.
Due to its similarity to human autoinflammatory diseases such as Familial Mediterranean Fever, SPAID research may provide valuable insights into both canine and human inflammatory conditions. Genetic screening and veterinary management are crucial for reducing disease impact and improving Shar-Pei welfare.
