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LABOKLIN (UK)| Genetic Diseases | Dogs| Belgian Shepherd Special Offer : SDCA1 + SDCA2+ CJM + CACA
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new test:      Paradoxical Pseudomyotonia (PP) in English Cocker and English Springer Spaniels  
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Belgian Shepherd Special Offer : SDCA1 + SDCA2+ CJM + CACA

Test number: 8634

Price: £ 126.00 (including VAT) for all 4 tests

  1 ) Spongy Degeneration with Cerebellar Ataxia ( SDCA1 )

Breeds
Belgian Shepherd Dog (Malinois) , Belgian Shepherd Dog , Dutch Shepherd .
The Disease
Spongy Degeneration with Cerebellar Ataxia, (SDCA2) is an inherited disease affecting the Belgian Shepherd breed. It is a severe neurodegenerative disease with monogenic autosomal recessive inheritance. The disease is characterised by rapidly progressing ataxia starting around the age of 5-8 weeks. Puppies are usually euthanised by the age of 8-12 weeks.

The disease can also be caused by another mutation SDCA2 . We also offer a combined SDCA1 + SDCA2 test in this breed.

Trait of Inheritance
.

Inheritance : AUTOSOMAL RECESSIVE trait


 

Sire

 

Dam

 

Offspring

         
clear
clear
100% clear
         
clear
carrier
50%  clear + 50% carriers
         
clear
affected
100% carriers
         
carrier
clear
50%  clear + 50% carriers
         
carrier
carrier
25% clear + 25% affected + 50% carriers
         
carrier
affected
50% carriers + 50% affected
         
affected
clear
100%  carriers
         
affected
carrier
50% carriers + 50% affected
         
affected
affected
100% affected

 


Clear

Genotype: N / N [ Homozygous normal ]

The dog is noncarrier of the mutant gene.

It is very unlikely that the dog will develop Spongy Degeneration with Cerebellar Ataxia ( SDCA1 ). The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.

 

Carrier

Genotype: N / SDCA1 [ Heterozygous ]

The dog carries one copy of the mutant gene and one copy of the normal gene.

It is very unlikely that the dog will develop Spongy Degeneration with Cerebellar Ataxia ( SDCA1 ) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%.

Carriers should only be bred to clear dogs.

Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)

 

Affected

Genotype: SDCA1 / SDCA1 [ Homozygous mutant ]

 

The dog carries two copies of the mutant gene and therefore it will pass the mutant gene to its entire offspring.

The dog is likely to develop Spongy Degeneration with Cerebellar Ataxia ( SDCA1 ) and will pass the mutant gene to its entire offspring
Sample Requirements
Whole blood in EDTA tube (0.5 - 1 ml) or Buccal Swabs.
Turnaround
1-2 weeks

  2 ) Spongy Degeneration with Cerebellar Ataxia ( SDCA2 )

Breeds
Belgian Shepherd Dog (Malinois) , Belgian Shepherd Dog , Dutch Shepherd .
The Disease
Spongy Degeneration with Cerebellar Ataxia, (SDCA2) is an inherited disease affecting the Belgian Shepherd breed. It is a severe neurodegenerative disease with monogenic autosomal recessive inheritance. The disease is characterised by rapidly progressing ataxia starting around the age of 5-8 weeks. Puppies are usually euthanised by the age of 8-12 weeks.

The disease can also be caused by another mutation SDCA1 . We also offer a combined SDCA1 + SDCA2 test in this breed.

Trait of Inheritance
.

Inheritance : AUTOSOMAL RECESSIVE trait


 

Sire

 

Dam

 

Offspring

         
clear
clear
100% clear
         
clear
carrier
50%  clear + 50% carriers
         
clear
affected
100% carriers
         
carrier
clear
50%  clear + 50% carriers
         
carrier
carrier
25% clear + 25% affected + 50% carriers
         
carrier
affected
50% carriers + 50% affected
         
affected
clear
100%  carriers
         
affected
carrier
50% carriers + 50% affected
         
affected
affected
100% affected

 


Clear

Genotype: N / N [ Homozygous normal ]

The dog is noncarrier of the mutant gene.

It is very unlikely that the dog will develop Spongy Degeneration with Cerebellar Ataxia ( SDCA2 ). The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.

 

Carrier

Genotype: N / SDCA2 [ Heterozygous ]

The dog carries one copy of the mutant gene and one copy of the normal gene.

It is very unlikely that the dog will develop Spongy Degeneration with Cerebellar Ataxia ( SDCA2 ) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%.

Carriers should only be bred to clear dogs.

Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)

 

Affected

Genotype: SDCA2 / SDCA2 [ Homozygous mutant ]

 

The dog carries two copies of the mutant gene and therefore it will pass the mutant gene to its entire offspring.

The dog is likely to develop Spongy Degeneration with Cerebellar Ataxia ( SDCA2 ) and will pass the mutant gene to its entire offspring
Sample Requirements
Whole blood in EDTA tube (0.5 - 1 ml) or Buccal Swabs.
Turnaround
1-2 weeks

  3 ) Cardiomyopathy with Juvenile Mortality (CJM)

Breeds
Belgian Shepherd Dog (Malinois) , Belgian Shepherd Dog .
The Disease
Cardiomyopathy and juvenile mortality (CJM) is an inherited disease affecting the Belgian Shepherd breed. The genetic variant that is associated with this disease has been identified and the test is now available at Laboklin. Affected puppies die at birth or at a maximum age of 6-8 weeks. In the latter case, puppies initially develop normally but then show unspecific symptoms like vomiting, uncoordinated movements, trembling or respiratory symptoms and die a few days after the first clinical signs, usually due to heart failure. The genetic analysis of CJM enables the selective mating of breeding dogs. Due to the autosomal recessive trait of inheritance, two copies of the mutation are required to cause the disease, and therefore dogs tested as carriers should not be removed from breeding but should only be bred with clear dogs to avoid having affected puppies.
Trait of Inheritance
autosomal recessive trait

Inheritance : AUTOSOMAL RECESSIVE trait


 

Sire

 

Dam

 

Offspring

         
clear
clear
100% clear
         
clear
carrier
50%  clear + 50% carriers
         
clear
affected
100% carriers
         
carrier
clear
50%  clear + 50% carriers
         
carrier
carrier
25% clear + 25% affected + 50% carriers
         
carrier
affected
50% carriers + 50% affected
         
affected
clear
100%  carriers
         
affected
carrier
50% carriers + 50% affected
         
affected
affected
100% affected

 


Clear

Genotype: N / N [ Homozygous normal ]

The dog is noncarrier of the mutant gene.

It is very unlikely that the dog will develop Cardiomyopathy with Juvenile Mortality (CJM). The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.

 

Carrier

Genotype: N / CJM [ Heterozygous ]

The dog carries one copy of the mutant gene and one copy of the normal gene.

It is very unlikely that the dog will develop Cardiomyopathy with Juvenile Mortality (CJM) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%.

Carriers should only be bred to clear dogs.

Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)

 

Affected

Genotype: CJM / CJM [ Homozygous mutant ]

 

The dog carries two copies of the mutant gene and therefore it will pass the mutant gene to its entire offspring.

The dog is likely to develop Cardiomyopathy with Juvenile Mortality (CJM) and will pass the mutant gene to its entire offspring
Sample Requirements
Whole blood in EDTA tube (0.5 - 1 ml) or Buccal Swabs.
Turnaround
1-2 weeks

  4 ) CNS Atrophy with Cerebellar Ataxia (CACA)

Breeds
Belgian Shepherd Dog (Malinois) , Belgian Shepherd Dog .
The Disease
Our cooperation partner Prof. Tosso Leeb and his team from the University of Bern have identified a new genetic variant causing a neurological disease called CNS atrophy and cerebellar ataxia (CACA) in the breed Belgian Shepherd. Affected puppies show uncoordinated movements, intention tremor, short episodes of spastic fits, general elevated muscle tone and a reduced swallowing reflex. Moreover, affected puppies show less body weight increase as their unaffected littermates. First signs could be observed at the age of about 2 weeks. However, the severity of the signs are highly variable. Many affected puppies have to be euthanized a few weeks after the first signs whereas an affected dog with less intense symptoms has been reported to become up to 10 years old.
Trait of Inheritance
trait of inheritance is autosomal recessive

Inheritance : AUTOSOMAL RECESSIVE trait


 

Sire

 

Dam

 

Offspring

         
clear
clear
100% clear
         
clear
carrier
50%  clear + 50% carriers
         
clear
affected
100% carriers
         
carrier
clear
50%  clear + 50% carriers
         
carrier
carrier
25% clear + 25% affected + 50% carriers
         
carrier
affected
50% carriers + 50% affected
         
affected
clear
100%  carriers
         
affected
carrier
50% carriers + 50% affected
         
affected
affected
100% affected

 


Clear

Genotype: N / N [ Homozygous normal ]

The dog is noncarrier of the mutant gene.

It is very unlikely that the dog will develop CNS Atrophy with Cerebellar Ataxia (CACA). The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.

 

Carrier

Genotype: N / [ Heterozygous ]

The dog carries one copy of the mutant gene and one copy of the normal gene.

It is very unlikely that the dog will develop CNS Atrophy with Cerebellar Ataxia (CACA) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%.

Carriers should only be bred to clear dogs.

Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)

 

Affected

Genotype: / [ Homozygous mutant ]

 

The dog carries two copies of the mutant gene and therefore it will pass the mutant gene to its entire offspring.

The dog is likely to develop CNS Atrophy with Cerebellar Ataxia (CACA) and will pass the mutant gene to its entire offspring
Sample Requirements
Whole blood in EDTA tube (0.5 - 1 ml) or Buccal Swabs.
Turnaround
2-3 weeks
Price for the above 4 tests
£ 126.00 (including VAT)

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