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Breeds
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Samoyed
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Sibirian Husky
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The Disease |
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Normally, the vision receptors in the eyes undergo a continual process of replacement and renewal. But with PRA this process slows and, one day, stops. The night vision receptors are the first to fail, and then, a while later, day vision starts to degenerate.
XL-PRA is a "late-onset" form of PRA. It usually isn't until dogs are three to five years old that the first clinical signs of disease start to manifest
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Trait of Inheritance |
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Inheritance : X-LINKED
RECESSIVE
trait
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Sire |
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Dam |
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Offspring |
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Males |
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Females |
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clear
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clear
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100% clear
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100% clear
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clear
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carrier
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50% clear + 50%
affected
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50% clear + 50%
carriers
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clear
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affected
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100% affected
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100% carriers
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affected
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clear
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100% clear
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100% carriers
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affected
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carrier
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50% affected + 50% clear
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50% affected + 50%
carriers
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affected
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affected
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100% affected
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100% affected
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Male:
Clear
Genotype: N [ normal ]
The dog is noncarrier of the mutant gene.
The dog will never develop XL - PRA (Progressive retinal Atrophy) and therefore it can be used in breeding and should only be bred to clear females.
Affected
Genotype: XL - PRA [ mutant ]
The dog carries the mutant gene and will pass it its entire female offspring.
The dog will develop XL - PRA (Progressive retinal Atrophy) and will pass the mutant gene to its entire female offspring
Female:
Clear
Genotype: N / N [ Homozygous normal ]
The dog is noncarrier of the mutant gene.
The dog will never develop XL - PRA (Progressive retinal Atrophy) and therefore it can be used in breeding and should only be bred to clear females.
Carrier
Genotype: N / XL - PRA [ Heterozygous ]
The dog carries one copy of the mutant gene and one
copy of the normal gene.
The dog will never develop XL - PRA (Progressive retinal Atrophy) but since it carries the mutant gene, it can pass it on to its offspring.
Affected
Genotype: XL - PRA / XL - PRA [ Homozygous mutant ]
The dog carries two copies of the mutant gene and
therefore it will pass the mutant gene to its entire offspring.
The dog will develop XL - PRA (Progressive retinal Atrophy) and will pass the mutant gene to its entire female offspring
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Description |
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Normally, the vision receptors in the eyes undergo a continual process of replacement and renewal. But with PRA this process slows and, one day, stops. The night vision receptors are the first to fail, and then, a while later, day vision starts to degenerate.
XL-PRA is a "late-onset" form of PRA. It usually isn't until dogs are three to five years old that the first clinical signs of disease start to manifest
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Sample Requirements |
Buccal swabs or 0.5 - 1 ml blood in EDTA Blood Tube . |
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Price
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£ 48.00 (including VAT)
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| To order:
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Download
Order Form from this link 
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Complete the order form and send it together
with your samples to the following address:
Laboklin (UK), 125 Northenden Road, Manchester, M33 3HF
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