LABOKLIN (UK)| Genetic Diseases | Cats| pd - Progressive Retinal Atrophy (pd-PRA)

pd - Progressive Retinal Atrophy (pd-PRA)

Test number: 8593
Gene: pd-PRA
Price: £ 48.00 (including VAT)

Breeds

Angora , British Shorthair , Birman (Sacred cat of Burma) , British Longhair , Chartreux , Colourpoint , Exotic Shorthair , Persian , Ragdoll , Russian Blue , Scottish Fold , Selkirk Rex .

The Disease

The pd- PRA-form of Progressive Retinal Atrophy is an autosomal recessive genetic disorder.

The onset of photoreceptor loss is around 5 weeks of age progressing to severe loss by the age of 16 weeks. Clinical symptoms include uncoordinated eye movement, increased eye-shine was reported as thinning of the retina progresses. Corneal thinning is not observed. Cats with one normal and one mutated gene (carriers) have normal vision although photoreceptor loss has been noted.

Trait of Inheritance

Autosomal Recessive

Inheritance : AUTOSOMAL RECESSIVE trait

Sire	Dam	Offspring

clear	clear	100% clear

clear	carrier	50% clear + 50% carriers

clear	affected	100% carriers

carrier	clear	50% clear + 50% carriers

carrier	carrier	25% clear + 25% affected + 50% carriers

carrier	affected	50% carriers + 50% affected

affected	clear	100% carriers

affected	carrier	50% carriers + 50% affected

affected	affected	100% affected

Clear

Genotype: N / N [ Homozygous normal ]

The cat is noncarrier of the mutant gene.
It is very unlikely that the cat will develop pd - Progressive Retinal Atrophy (pd-PRA). The cat will never pass the mutation to its offspring, and therefore it can be bred to any other cat.

Carrier

Genotype: N / pd-PRA [ Heterozygous ]

The cat carries one copy of the mutant gene and one copy of the normal gene.
It is very unlikely that the cat will develop pd - Progressive Retinal Atrophy (pd-PRA) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%.
Carriers should only be bred to clear cats.
Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)

Affected

Genotype: pd-PRA / pd-PRA [ Homozygous mutant ]

The cat carries two copies of the mutant gene and therefore it will pass the mutant gene to its entire offspring.
The cat is likely to develop pd - Progressive Retinal Atrophy (pd-PRA) and will pass the mutant gene to its entire offspring