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1 ) Late Onset Ataxia (LOA)
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Breeds
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Jack Russell Terrier
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Parson Russell Terrier (PRT)
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Kennel Club
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This test is part of the Official UK Kennel Club DNA Testing Scheme in Jack Russell Terrier.
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The Disease |
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Late onset ataxia (LOA) in the Parson Russell Terrier is a genetic disease characterised by progressive gait incoordination and loss of balance. Early symptoms are usually seen at the age of 6-12 month, the disease progresses, gait becomes increasingly incoordinated with difficulty in moving around or complete loss of mobility.
This disease is caused by a mutation in the calcium activated neutral proteinase 1 (CAPN1)-gene.
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Trait of Inheritance |
Recessive trait of inheritance
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Inheritance : AUTOSOMAL
RECESSIVE
trait
Sire
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Dam
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Offspring
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clear
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clear
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100% clear
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clear
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carrier
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50% clear + 50%
carriers
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clear
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affected
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100% carriers
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carrier
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clear
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50% clear + 50%
carriers
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carrier
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carrier
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25% clear + 25% affected
+ 50% carriers
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carrier
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affected
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50% carriers + 50%
affected
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affected
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clear
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100% carriers
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affected
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carrier
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50% carriers + 50%
affected
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affected
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affected
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100% affected
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Clear
Genotype: N / N [ Homozygous normal ]
The dog is noncarrier of the mutant gene.
It is very unlikely that the dog will develop Late Onset Ataxia (LOA). The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.
Carrier
Genotype: N / LOA [ Heterozygous ]
The dog carries one copy of the mutant gene and one
copy of the normal gene.
It is very unlikely that the dog will develop Late Onset Ataxia (LOA) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%. Carriers should only be bred to clear dogs. Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)
Affected
Genotype: LOA / LOA [ Homozygous mutant ]
The dog carries two copies of the mutant gene and
therefore it will pass the mutant gene to its entire offspring.
The dog is likely to develop Late Onset Ataxia (LOA) and will pass the mutant gene to its entire offspring
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Sample Requirements |
Whole blood in EDTA tube (0.5 - 1 ml) or Buccal swabs. .
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2 ) Spinocerebellar ataxia (SCA)
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Breeds
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Alpine Dachsbracke
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Fox Terrier
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Jack Russell Terrier
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Parson Russell Terrier (PRT)
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Tenterfield Terrier
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Kennel Club
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This test is part of the Official UK Kennel Club DNA Testing Scheme in Jack Russell Terrier , and Parson Russell Terrier (PRT).
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The Disease |
spinocerebellar ataxia is an inherited disorder of the cerebellum in which affected dogs suffer a poorly coordinated movement, goose-stepping gait when getting excited or when excercised, sometimes there is lack of balance and frequent falling.
* partner lab
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Sample Requirements |
Whole blood in EDTA tube (0.5 - 1 ml) or Buccal swabs. .
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3 ) Juvenile Brain Disease ( JBD ) / Juvenile Encephalopathy ( Epilepsy )
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Breeds
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Jack Russell Terrier
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Parson Russell Terrier (PRT)
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Description |
Juvenile Encephalopathy is a severe brain disorder, with an early onset of around 6-12 weeks. Affected dogs suffer from epileptic seizures, with the disease progressing rapidly causing irreversible brain damage.
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Sample Requirements |
Whole blood in EDTA tube (0.5 - 1 ml) or Buccal swabs. .
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Price
for the above 3 tests
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£ 126.00 (including VAT)
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To order:
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Download
Order Form from this link 
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Complete the order form and send it together
with your samples to the following address:
Laboklin (UK), 125 Northenden Road, Manchester, M33 3HF
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