LABOKLIN (UK)| Genetic Diseases | Dogs| Protein Losing Nephropathy (PLN)
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Protein Losing Nephropathy (PLN)

Test number: 8492 (this test number replaces the old 8307D)
Gene: PLN
Price: £ 48.00 (including VAT)
Breeds
Airedale Terrier , Soft Coated Wheaten Terrier .
The Disease
Protein Losing Nephropathy (PLN) is an inherited disease that affect Soft-Coated Wheaten Terriers and results in essential proteins being lost through the kidney. The disease can be mild and stable for years, however, it may lead to severe complications including kidney failure. Progression of the symptoms is variable and often influenced by environmental factors.
Clinical Signs
Symptoms include but not limited to depression, decreased appetite, vomiting, weight loss, Ascites, oedema, pleural effusion and Increased water consumption.

Lab tests shows decreased blood albumin levels and elevated urine proteine / creatinine ratio, and sometimes Elevated serum creatinine, BUN (later), Hypercholesterolemia, Elevated MA (Microalbuminuria). Laboratory abnormalities are not seen in every case.

Trait of Inheritance
Heterozygous dogs (N/PLN) may have moderate risk of developing the disease;
homozygous (PLN / PLN) affected dogs at higher risk of developing the disease.

Inheritance : AUTOSOMAL trait
Description

Diagnosis of PLN has always been difficult, especially in the early stages of the disease, it can be misdiagnosed as liver, gland or other kidney diseases. Thanks to advances in molecular biology, teh mutation associated with PLN has been identified and Laboklin can now offer a DNA testfor PLN in Soft-Coated Wheaten Terriers.

Sample Requirements
Whole blood in EDTA tube (0.5 - 1 ml) or Buccal Swabs.
Turnaround
1-2 weeks
Price
£ 48.00 (including VAT)

To order:




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