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new test:      Paradoxical Pseudomyotonia (PP) in English Cocker and English Springer Spaniels  
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Mucopolysaccharidosis type VII (MPS VII / MPS7)

Test number: 8473
Gene: MPS VII
Price: £ 48.00 (including VAT)
Breed
All Cat Breeds .
The Disease
Mucopolysaccharidosis type VII (MPS VII) is a rare progressive, autosomal recessive disorder of the lysosomal storage caused by a mutation in the gene for the enzyme ß-glucuronidase (GUSB). In heterozygous cats (N / mps) only half the normal amount of the enzyme is produced, whereas affected cats (mps / mps) do not produce the enzyme at all. Clinical symptoms start by three months of age and include gait abnormalities, possibly due to muscle weakness, as well as bone abnormalities, disproportionate skull to body ratio, plump paws and corneal clouding, among other defects. Most affected animals must be euthanized by 6 months.
Trait of Inheritance
Autosomal recessive

Inheritance : AUTOSOMAL RECESSIVE trait


 

Sire

 

Dam

 

Offspring

         
clear
clear
100% clear
         
clear
carrier
50%  clear + 50% carriers
         
clear
affected
100% carriers
         
carrier
clear
50%  clear + 50% carriers
         
carrier
carrier
25% clear + 25% affected + 50% carriers
         
carrier
affected
50% carriers + 50% affected
         
affected
clear
100%  carriers
         
affected
carrier
50% carriers + 50% affected
         
affected
affected
100% affected

 


Clear

Genotype: N / N [ Homozygous normal ]

The cat is noncarrier of the mutant gene.

It is very unlikely that the cat will develop Mucopolysaccharidosis type VII (MPS VII / MPS7). The cat will never pass the mutation to its offspring, and therefore it can be bred to any other cat.

 

Carrier

Genotype: N / MPS VII [ Heterozygous ]

The cat carries one copy of the mutant gene and one copy of the normal gene.

It is very unlikely that the cat will develop Mucopolysaccharidosis type VII (MPS VII / MPS7) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%.

Carriers should only be bred to clear cats.

Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)

 

Affected

Genotype: MPS VII / MPS VII [ Homozygous mutant ]

 

The cat carries two copies of the mutant gene and therefore it will pass the mutant gene to its entire offspring.

The cat is likely to develop Mucopolysaccharidosis type VII (MPS VII / MPS7) and will pass the mutant gene to its entire offspring
Sample Requirements
Whole blood in EDTA tube (0.5 - 1 ml) or Buccal Swabs.
Turnaround
2 - 3 weeks
Price
£ 48.00 (including VAT)

To order:




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See also:

 
 
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