LABOKLIN (UK)| Genetic Diseases | Cats| Mucopolysaccharidosis type VII (MPS VII / MPS7)

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Mucopolysaccharidosis type VII (MPS VII / MPS7) Test number: 8473 Gene: MPS VII Price: £ 48.00 (including VAT)

Breed

All Cat Breeds .

The Disease

Mucopolysaccharidosis type VII (MPS VII) is a rare progressive, autosomal recessive disorder of the lysosomal storage caused by a mutation in the gene for the enzyme ß-glucuronidase (GUSB). In heterozygous cats (N / mps) only half the normal amount of the enzyme is produced, whereas affected cats (mps / mps) do not produce the enzyme at all. Clinical symptoms start by three months of age and include gait abnormalities, possibly due to muscle weakness, as well as bone abnormalities, disproportionate skull to body ratio, plump paws and corneal clouding, among other defects. Most affected animals must be euthanized by 6 months.

Trait of Inheritance

Autosomal recessive

Inheritance : AUTOSOMAL RECESSIVE trait

Sire	Dam	Offspring

clear	clear	100% clear

clear	carrier	50% clear + 50% carriers

clear	affected	100% carriers

carrier	clear	50% clear + 50% carriers

carrier	carrier	25% clear + 25% affected + 50% carriers

carrier	affected	50% carriers + 50% affected

affected	clear	100% carriers

affected	carrier	50% carriers + 50% affected

affected	affected	100% affected

Clear

Genotype: N / N [ Homozygous normal ]

The cat is noncarrier of the mutant gene.
It is very unlikely that the cat will develop Mucopolysaccharidosis type VII (MPS VII / MPS7). The cat will never pass the mutation to its offspring, and therefore it can be bred to any other cat.

Carrier

Genotype: N / MPS VII [ Heterozygous ]

The cat carries one copy of the mutant gene and one copy of the normal gene.
It is very unlikely that the cat will develop Mucopolysaccharidosis type VII (MPS VII / MPS7) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%.
Carriers should only be bred to clear cats.
Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)

Affected

Genotype: MPS VII / MPS VII [ Homozygous mutant ]

The cat carries two copies of the mutant gene and therefore it will pass the mutant gene to its entire offspring.
The cat is likely to develop Mucopolysaccharidosis type VII (MPS VII / MPS7) and will pass the mutant gene to its entire offspring

Sample Requirements

Whole blood in EDTA tube (0.5 - 1 ml) or Buccal Swabs.

Turnaround

2-3 weeks

Price

£ 48.00 (including VAT)

To order:

Download Order Form from this link
Complete the order form and send it together with your samples to the following address:
Laboklin (UK), Unit 20, Wheel Forge Way, Trafford Park, Manchester, M17 1EH
Buccal swabs and EDTA tubes are available from us free of charge, to order, please use the online form <Request sample collection materials> or email: info@laboklin.co.uk.
If you are sending swab samples, please follow the instructions on this link .

If you have any queries, please contact us on 0161 282 3066

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Sire

Dam

Offspring