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The Disease |
A recessive mutation that causes a congenital craniofacial defect in Burmese cats has been identified by the Lyons Feline Genetics Research Laboratory at UC Davis.The mutation affects function of a gene significant for facial development.
Cats with one copy of the mutation will not have craniofacial defect but may produce a shortened facial structure (brachycephaly). Research is underway to determine if cats that have one copy or no copies of the mutation can be identified just by facial type. Two copies of the mutant allele can cause severe craniofacial defect that is severe enough to be compatible with life. |
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Trait of Inheritance |
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Autosomal recessive (see interpretation below)
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Inheritance : AUTOSOMAL
RECESSIVE
trait
Sire
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Dam
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Offspring
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clear
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clear
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100% clear
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clear
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carrier
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50% clear + 50%
carriers
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clear
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affected
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100% carriers
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carrier
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clear
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50% clear + 50%
carriers
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carrier
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carrier
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25% clear + 25% affected
+ 50% carriers
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carrier
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affected
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50% carriers + 50%
affected
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affected
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clear
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100% carriers
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affected
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carrier
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50% carriers + 50%
affected
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affected
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affected
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100% affected
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Clear
Genotype: N / N [ Homozygous normal ]
The cat is noncarrier of the mutant gene.
It is very unlikely that the cat will develop Head Defect (BHD). The cat will never pass the mutation to its offspring, and therefore it can be bred to any other cat.
Carrier
Genotype: N / BHD [ Heterozygous ]
The cat carries one copy of the mutant gene and one
copy of the normal gene.
Cats with one copy of the mutation will not have craniofacial defect but may produce a shortened facial structure (brachycephaly).
Affected
Genotype: BHD / BHD [ Homozygous mutant ]
The cat carries two copies of the mutant gene and
therefore it will pass the mutant gene to its entire offspring.
The cat is likely to develop Head Defect (BHD) and will pass the mutant gene to its entire offspring
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Sample Requirements |
Whole blood in EDTA tube (0.5 - 1 ml) or Buccal swabs. . |
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Price
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£ 48.00 (including VAT)
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| To order:
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Download
Order Form from this link 
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Complete the order form and send it together
with your samples to the following address:
Laboklin (UK), 125 Northenden Road, Manchester, M33 3HF
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