LABOKLIN (UK)| Genetic Diseases | Cats| Head Defect (BHD)

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Head Defect (BHD) Test number: 8465 (this test number replaces the old 8465C) Gene: BHD Price: £ 48.00 (including VAT)

Breed

Burmese .

The Disease

A recessive mutation that causes a congenital craniofacial defect in Burmese cats has been identified by the Lyons Feline Genetics Research Laboratory at UC Davis.The mutation affects function of a gene significant for facial development.

Cats with one copy of the mutation will not have craniofacial defect but may produce a shortened facial structure (brachycephaly). Research is underway to determine if cats that have one copy or no copies of the mutation can be identified just by facial type. Two copies of the mutant allele can cause severe craniofacial defect that is severe enough to be compatible with life.

Trait of Inheritance

Autosomal recessive (see interpretation below)

Inheritance : AUTOSOMAL RECESSIVE trait

Sire	Dam	Offspring

clear	clear	100% clear

clear	carrier	50% clear + 50% carriers

clear	affected	100% carriers

carrier	clear	50% clear + 50% carriers

carrier	carrier	25% clear + 25% affected + 50% carriers

carrier	affected	50% carriers + 50% affected

affected	clear	100% carriers

affected	carrier	50% carriers + 50% affected

affected	affected	100% affected

Clear

Genotype: N / N [ Homozygous normal ]

The cat is noncarrier of the mutant gene.
It is very unlikely that the cat will develop Head Defect (BHD). The cat will never pass the mutation to its offspring, and therefore it can be bred to any other cat.

Carrier

Genotype: N / BHD [ Heterozygous ]

The cat carries one copy of the mutant gene and one copy of the normal gene.
Cats with one copy of the mutation will not have craniofacial defect but may produce a shortened facial structure (brachycephaly).

Affected

Genotype: BHD / BHD [ Homozygous mutant ]

The cat carries two copies of the mutant gene and therefore it will pass the mutant gene to its entire offspring.
The cat is likely to develop Head Defect (BHD) and will pass the mutant gene to its entire offspring

Sample Requirements

Whole blood in EDTA tube (0.5 - 1 ml) or Buccal Swabs.

Turnaround

1 -2 weeks

Price

£ 48.00 (including VAT)

To order:

Download Order Form from this link
Complete the order form and send it together with your samples to the following address:
Laboklin (UK), Unit 20, Wheel Forge Way, Trafford Park, Manchester, M17 1EH
Buccal swabs and EDTA tubes are available from us free of charge, to order, please use the online form <Request sample collection materials> or email: info@laboklin.co.uk.
If you are sending swab samples, please follow the instructions on this link .

If you have any queries, please contact us on 0161 282 3066

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Sire

Dam

Offspring