LABOKLIN (UK)| Genetic Diseases | Cats| Myotonia Congenita (Fainting Goat)
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Myotonia Congenita (Fainting Goat)

Test number: 8461
Gene: MC
Price: £ 48.00 (including VAT)
Breed
All Cat Breeds .
The Disease
Myotonia congenita (MC) is a skeletal muscle channelopathy characterized by inability of the muscle to relax following voluntary contraction.

myotonia Congenita is associated with functional defects in chloride channels and mutations in a skeletal muscle chloride channel (CLCN1), which encodes for the most abundant chloride channel in the skeletal muscle cell membrane.

Clinical symptoms include restricted jaw opening, halitosis, varying degrees of gingivitis, pseudoptyalism, marked dental calculus accumulation with palpable loose teeth and evidence of poor grooming habits. Severe muscle hypertrophy was found along the cervical spine, proximal aspects of all limbs and the tongue, which protruded from the mouth, hard-to-open mandible. Often, trouble swallowing, as well as observed excessive salivation.

Trait of Inheritance
Autosomal Recessive

Inheritance : AUTOSOMAL RECESSIVE trait


 

Sire

 

Dam

 

Offspring

         
clear
clear
100% clear
         
clear
carrier
50%  clear + 50% carriers
         
clear
affected
100% carriers
         
carrier
clear
50%  clear + 50% carriers
         
carrier
carrier
25% clear + 25% affected + 50% carriers
         
carrier
affected
50% carriers + 50% affected
         
affected
clear
100%  carriers
         
affected
carrier
50% carriers + 50% affected
         
affected
affected
100% affected

 


Clear

Genotype: N / N [ Homozygous normal ]

The cat is noncarrier of the mutant gene.

It is very unlikely that the cat will develop Myotonia Congenita (Fainting Goat). The cat will never pass the mutation to its offspring, and therefore it can be bred to any other cat.

 

Carrier

Genotype: N / MC [ Heterozygous ]

The cat carries one copy of the mutant gene and one copy of the normal gene.

It is very unlikely that the cat will develop Myotonia Congenita (Fainting Goat) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%.

Carriers should only be bred to clear cats.

Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)

 

Affected

Genotype: MC / MC [ Homozygous mutant ]

 

The cat carries two copies of the mutant gene and therefore it will pass the mutant gene to its entire offspring.

The cat is likely to develop Myotonia Congenita (Fainting Goat) and will pass the mutant gene to its entire offspring
Description

Sample Requirements
Whole blood in EDTA tube (0.5 - 1 ml) or Buccal Swabs.
Turnaround
2-3 weeks
Price
£ 48.00 (including VAT)

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