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LABOKLIN (UK)| Genetic Diseases | Dogs| CKCS Pack A: Episodic Falling + Dry Eye Curly Coat syndrome
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CKCS Pack A: Episodic Falling + Dry Eye Curly Coat syndrome

Test number: 8407

Price: £ 66.00 (including VAT) for all 2 tests

  1 ) Episodic Falling in Cavalier King Charles Spaniel (EF)

Breeds
Cavalier King Charles Spaniel , Cavapoo .
Kennel Club
This test is part of the Official UK Kennel Club DNA Testing Scheme in Cavalier King Charles Spaniel.

for UK registered dogs, Laboklin can send results of the tests which are part of the Official UK Kennel Club DNA testing scheme to the Kennel Club (KC) to be recorded and published as part of the Kennel Club scheme. Results will only be recorded and published by the KC if the result report includes the dog’s microchip or tattoo number along with either the dog’s registered name or registered number. Any test results that do not carry these identifying features will not be recorded by the Kennel Club.

In order to ensure that test results are sent to the Kennel Club, customers must also sign the declaration section on the order form to give Laboklin permission to do so.

important: When you sign the declaration, Laboklin will send the results to the KC on your behalf, and you do not need to send them to the KC yourself again to avoid unnecessary duplications.

The Disease
Episodic Falling is a genetic neurological disorder found in Cavalier King Charles Spaniels. Episodes are usually triggered by exercise, stress or excitement and are characterised by increased muscle tone and stiffness throughout the thoracic and pelvic limbs resulting in a characteristic 'deer-stalking' position and or collapse. The onset of symptoms is usually between fourteen weeks and four years of age but may appear at any age. Clinical symptoms vary in severity ranging from mild, occasional falling to freezing or seizure-like episodes lasting hours. Severity of the episodes can increase or decrease as the dog gets older. There is no standard pattern to the attacks.

The disease is also known as Exercise-Induced Paroxysmal Hypertonicity, Falling Cavaliers and Collapsing Cavalier Syndrome.

Prof. Dr. Robert Harvey of the London School of Pharmacy has recently identified the underlying genetic defect causing Episodic Falling in Cavalier King Charles Spaniels. LABOKLIN have recently implemented the genetic test for this disease under licence from the London School of Pharmacy. This test is currently patented within Europe, with Laboklin as the testing laboratory.

Trait of Inheritance
Episodic Falling is inherited as a autosomal recessive trait

Inheritance : AUTOSOMAL RECESSIVE trait


 

Sire

 

Dam

 

Offspring

         
clear
clear
100% clear
         
clear
carrier
50%  clear + 50% carriers
         
clear
affected
100% carriers
         
carrier
clear
50%  clear + 50% carriers
         
carrier
carrier
25% clear + 25% affected + 50% carriers
         
carrier
affected
50% carriers + 50% affected
         
affected
clear
100%  carriers
         
affected
carrier
50% carriers + 50% affected
         
affected
affected
100% affected

 


Clear

Genotype: N / N [ Homozygous normal ]

The dog is noncarrier of the mutant gene.

It is very unlikely that the dog will develop Episodic Falling in Cavalier King Charles Spaniel (EF). The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.

 

Carrier

Genotype: N / EF [ Heterozygous ]

The dog carries one copy of the mutant gene and one copy of the normal gene.

It is very unlikely that the dog will develop Episodic Falling in Cavalier King Charles Spaniel (EF) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%.

Carriers should only be bred to clear dogs.

Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)

 

Affected

Genotype: EF / EF [ Homozygous mutant ]

 

The dog carries two copies of the mutant gene and therefore it will pass the mutant gene to its entire offspring.

The dog is likely to develop Episodic Falling in Cavalier King Charles Spaniel (EF) and will pass the mutant gene to its entire offspring
Description

We also have a special offer:

Episodic Falling + Dry Eye and Curly Coat syndrome
LIMITED PERIOD SPECIAL OFFER PRICE ONLY £66 (INCL VAT) FOR BOTH TESTS.

Click here for details OFFER

Sample Requirements
Whole blood in EDTA tube (0.5 - 1 ml) or Buccal Swabs.
Turnaround
1 - 2 weeks

We will run this test 2 independant times on your sample to ensure that the result is 100% accurate


  2 ) Dry Eye and Curly Coat syndrome (CCS)

Breeds
Cavalier King Charles Spaniel , Cavapoo .
Kennel Club
This test is part of the Official UK Kennel Club DNA Testing Scheme in Cavalier King Charles Spaniel.

for UK registered dogs, Laboklin can send results of the tests which are part of the Official UK Kennel Club DNA testing scheme to the Kennel Club (KC) to be recorded and published as part of the Kennel Club scheme. Results will only be recorded and published by the KC if the result report includes the dog’s microchip or tattoo number along with either the dog’s registered name or registered number. Any test results that do not carry these identifying features will not be recorded by the Kennel Club.

In order to ensure that test results are sent to the Kennel Club, customers must also sign the declaration section on the order form to give Laboklin permission to do so.

important: When you sign the declaration, Laboklin will send the results to the KC on your behalf, and you do not need to send them to the KC yourself again to avoid unnecessary duplications.

The Disease
Affected dog puppies suffer from keratoconjunctivitis sicca from eyelid opening, abnormal (rough/curly) coat and are usually smaller than littermates. Footpads are hyper keratinised from young adulthood including nail growth abnormalities and intermittent sloughing, pain and lameness.
Description

We also have a special offer:

Episodic Falling + Dry Eye and Curly Coat syndrome
LIMITED PERIOD SPECIAL OFFER PRICE ONLY £66 (INCL VAT) FOR BOTH TESTS.

Click here for details OFFER

Sample Requirements
Whole blood in EDTA tube (0.5 - 1 ml) or Buccal Swabs.
Turnaround
1 - 2 weeks
Price for the above 2 tests
£ 66.00 (including VAT)

To order:




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See also:

 
 
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