LABOKLIN (UK)| Genetic Diseases | Dogs| Progressive Retinal Atrophy (Dominant PRA)
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Progressive Retinal Atrophy (Dominant PRA)

Test number: 8355 (this test number replaces the old 8002)
Gene: PRA
Price: £ 48.00 (including VAT)
Breeds
Bull Mastiff , English Mastiff .
The Disease
Progressive retinal atrophy (PRA) is a leading hereditary cause of blindness in pedigree dogs as is its counterpart retinitis pigmentosa (RP) in humans. PRA shows genetic heterogeneity, as does RP, with several distinct forms already recognized and several more remaining to be investigated. Pups show signs of night-blindness by 6 weeks of age. By the age of 1-2 years most affected dogs are completely blind.
Trait of Inheritance
Mastiffs and Bullmastiffs exhibit the first, and so far, only form of canine Progressive Retinal Atrophy - PRA - that is inherited as a dominant trait. Therefore only affected or unaffected dogs can be found. The Mastiffs are affected by the late onset form of the PRA. Since vision loss might be recognised first when the dog is several years old, it is important to determine the actual status of the dog before breeding it.

Inheritance : AUTOSOMAL DOMINANT trait
Description

This is a mutation-based gene test, which offers many advantages over other methods

Progress in molecular genetics has allowed the identification of the gene mutation responsible for PRA in the Bull and English Mastiff. By DNA testing, the responsible mutation can be shown directly. This method provides a very high accuracy test and can be done at any age. It offers the possibility to distinguish between affected and clear dogs. This is an essential information for controlling the disease in the breed.

Sample Requirements
Whole blood in EDTA tube (0.5 - 1 ml) or Buccal Swabs.
Turnaround
2-3 weeks
Price
£ 48.00 (including VAT)

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