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**NEW**



Bengal Special offer:
3 Bengal Specific DNA tests for just £60.00 incl VAT
Bengal DNA bundle (rdAc-PRA + b-PRA + PK-Def) 



British Special offer:
3 Breed Specific DNA tests for just £60.00 incl VAT
British Short / Long Hair DNA bundle (PKD + pd-PRA + ALS)



Burmese Special offer:
3 Breed Specific DNA tests for just £66.00 incl VAT
Burmese DNA bundle (Hypokalemia (BHK) + Head Defect + Gangliosidosis (GM2)



Birman Special offer:
4 Breed Specific DNA tests for just £66.00 incl VAT
Birma DNA bundle (PKD + pd-PRA + Hypotrichiose + MPS6)



Maine Coon Special offer:
3 Breed Specific DNA tests for just £60.00 incl VAT
Maine Coon DNA bundle (HCM1 + SMA + PK-Def)



Ragdoll Special offer:
4 Breed Specific DNA tests for just £60.00 incl VAT
Ragdoll DNA bundle (HCM1 + HCM3 + PKD + pd-PRA)



Norwegian Special offer:
3 Breed Specific DNA tests for just £60.00 incl VAT
Norwegian Forest DNA bundle (PK-Def + Amber + GSD4)



Feline Special Offer:
8 cat DNA tests for just £79.95 including VAT
HCM, HCR, GSD4, PKD, PRA, PK-Def., SMA, Blood Groups

new test: Cocoa (Chocolate / Brown ) in French Bulldog
new test: Stargardt disease ( STGD )  and  Copper storage disease - Copper toxicosis (CT) in Labrador Retriever
new test: Inflammatory Pulmonary Disease ( IPD ) in Rough and Smooth Collies
new test: Lafora Disease in Basset Hound, Beagle, Chihuahua, French Bulldog, Welsh Corgi and Mini Wirehaired Dachshund
new Kennel Club DNA testing schemes with LABOKLIN:
• Pug Dog Encephalitis (PDE) / Necrotizing Meningoencephalitis (NME) in Pug
• Progressive Retinal Atrophy (prcd-PRA) and • Progressive retinal atrophy ( rcd4-PRA) / LOPRA in Standard Poodle
• Dwarfism ( Chondrodysplasia / disproportinate short-limbed ) and • Primary Open Angle Glaucoma (POAG) in Norwegian Elkhounds


Progressive Retinal Atrophy in Bengal (PRA-b / b-PRA)

Test number: 8331

PRA-b

Breed
Bengal .
The Disease
Bengal Progressive Retinal Atrophy (PRA-b) is an inherited eye disease affecting the Bengal cat. The disease is characterised by progressive blindness that starts around the age of 7 weeks and slowly progresses until the cat has very compromised vision around the age of two years. The disease develps at different rates in the different cats. The pupil in affected cats is more dilated compared to cats with normal vision. Affected cats tend to carry their whiskers forward. Blind cats tend to have more difficulty at night, sometimes becoming more vocal and more attached to their owners.

The trait of inheritance is autosomal recessive which means that the disease can affect both male and female cats and that a cat can only develop the disease if it inherits two copies of the mutation one from the mother and one from the father. Carries do not develp the disease but they can pass the mutation to offspring and therefore they should only be bred to clear cats. DNA testing enables breeders to breed healthy kittens.

The test is offered in cooperation with the Veterinary Genetic Laboratory at the University of California.

Trait of Inheritance
Autosomal Recessive

Inheritance : AUTOSOMAL RECESSIVE trait


 

Sire

 

Dam

 

Offspring

         
clear
clear
100% clear
         
clear
carrier
50%  clear + 50% carriers
         
clear
affected
100% carriers
         
carrier
clear
50%  clear + 50% carriers
         
carrier
carrier
25% clear + 25% affected + 50% carriers
         
carrier
affected
50% carriers + 50% affected
         
affected
clear
100%  carriers
         
affected
carrier
50% carriers + 50% affected
         
affected
affected
100% affected

 


Clear

Genotype: N / N [ Homozygous normal ]

The cat is noncarrier of the mutant gene.

It is very unlikely that the cat will develop Progressive Retinal Atrophy in Bengal (PRA-b / b-PRA). The cat will never pass the mutation to its offspring, and therefore it can be bred to any other cat.

 

Carrier

Genotype: N / PRA-b [ Heterozygous ]

The cat carries one copy of the mutant gene and one copy of the normal gene.

It is very unlikely that the cat will develop Progressive Retinal Atrophy in Bengal (PRA-b / b-PRA) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%.

Carriers should only be bred to clear cats.

Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)

 

Affected

Genotype: PRA-b / PRA-b [ Homozygous mutant ]

 

The cat carries two copies of the mutant gene and therefore it will pass the mutant gene to its entire offspring.

The cat is likely to develop Progressive Retinal Atrophy in Bengal (PRA-b / b-PRA) and will pass the mutant gene to its entire offspring
Sample Requirements
Whole blood in EDTA tube (0.5 - 1 ml) or Buccal Swabs.
Whole blood in EDTA tube (0.5 - 1 ml) or Buccal swabs. .
Turnaround
1-2 weeks
Price
£ 48.00 (including VAT)

To order:

  • Download Order Form from this link pdf

  • Complete the order form and send it together with your samples to the following address:

    Laboklin (UK),   125 Northenden Road, Manchester, M33 3HF




new test:
Androgen Insensitivity Syndrome (AIS)
new test:
ACAN Dwarfism (Chondrodysplasia)
new test:
Predictive Height Test ( LCORL)
new test:

Tractability
new test:
Coat colour Sunshire Dilution



See also:
HCM 1 (Hypertrophic cardiomyopathy ) Mutation Meurs (G-- > C) A31P  
Norwegian Forest DNA bundle (PK-Def + Amber + GSD4)  
HCM (Hypertrophic Cardiomyopathy HCM3/HCR)  
PKD (Feline Polycystic Kidney Disease)  
PK Deficiency (Pyruvate Kinase Deficiency)  
rdAc-PRA (Progressive Retinal Atrophy )  
Genetic Blood groups in cats  
SMA (Spinal Muscular Atrophy )  
Serological Evaluation of blood Groups  
Hypokalemia / Familial Episodic Hypokalaemic Polymyopathy (BHK)  
Head Defect (BHD)  
Alpha-Mannosidosis (AMD)  
Congenital Myasthenic Syndrome (CMS)  
Gangliosidosis GM1  
Gangliosidosis GM2  
Gangliosidosis GM2  
Mucopolysaccharidosis Type VI (MPS VI MPS6)  
Mucopolysaccharidosis type VII (MPS VII / MPS7)  
Myotonia Congenita (Fainting Goat)  
pd - Progressive Retinal Atrophy (pd-PRA)  
Progressive Retinal Atrophy (rdy-PRA)  
Hypotrichosis and Short Life Expectancy  
Special Offer: HCM, HCR, GSD4, PKD, PRA, PK-Def., SMA, Blood Groups  
Osteochondrodysplasia (Scottish Fold Osteodystrophy)  
Primary Congenital Glaucoma (PCG)  
Autoimmune Lymphoproliferative Syndrome (ALPS)  
Cystinuria (Feline Cystinuria) (CY)  
Persian DNA bundle (PKD + pd-PRA + AMD)  
British Short / Long Hair DNA bundle (PKD + pd-PRA + ALS)  
Burmese DNA bundle (Hypokalemia (BHK) + Head Defect + Gangliosidosis (GM2)  
Birma DNA bundle (PKD + pd-PRA + Hypotrichiose + MPS6)  
Bengal DNA bundle (rdAc-PRA + b-PRA + PK-Def)  
Maine Coon DNA bundle (HCM1 + SMA + PK-Def)  
Ragdoll DNA bundle (HCM1 + HCM3 + PKD + pd-PRA)  
Glycogen Storage Disease ( GSD ) Type IV  

 
 
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© 2007 Laboklin (UK)
125 Northenden Road, Manchester, M33 3HF
Tel. 0161 282 3066