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LABOKLIN (UK)| Genetic Diseases | Dogs| Cleft Lip / Palate and Syndactyly (CLPS)
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Cleft Lip / Palate and Syndactyly (CLPS)

Test number: 8326
Gene: CLPS
Price: £ 48.00 (including VAT)
Breed
Nova Scotia Duck tolling Retriever ( NSDTR / Toller) .
The Disease
Cleft palate is a hole in the roof of the mouth that occurs during development of the puppy. Affected puppies are born with cleft palate. Cleft Lip is split in the lip and can occur on one or both sides of the mouth. Syndactyly is fusion of the middle two digits of the feet.

Phenotype varies from cleft palate only to cleft lip and cleft palate and in both cases puppies can have syndactyly but don’t always. A case of cleft nose and syndactyly has been reported.

Trait of Inheritance
.

Inheritance : AUTOSOMAL RECESSIVE trait


 

Sire

 

Dam

 

Offspring

         
clear
clear
100% clear
         
clear
carrier
50%  clear + 50% carriers
         
clear
affected
100% carriers
         
carrier
clear
50%  clear + 50% carriers
         
carrier
carrier
25% clear + 25% affected + 50% carriers
         
carrier
affected
50% carriers + 50% affected
         
affected
clear
100%  carriers
         
affected
carrier
50% carriers + 50% affected
         
affected
affected
100% affected

 


Clear

Genotype: N / N [ Homozygous normal ]

The dog is noncarrier of the mutant gene.

It is very unlikely that the dog will develop Cleft Lip / Palate and Syndactyly (CLPS). The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.

 

Carrier

Genotype: N / CLPS [ Heterozygous ]

The dog carries one copy of the mutant gene and one copy of the normal gene.

It is very unlikely that the dog will develop Cleft Lip / Palate and Syndactyly (CLPS) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%.

Carriers should only be bred to clear dogs.

Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)

 

Affected

Genotype: CLPS / CLPS [ Homozygous mutant ]

 

The dog carries two copies of the mutant gene and therefore it will pass the mutant gene to its entire offspring.

The dog is likely to develop Cleft Lip / Palate and Syndactyly (CLPS) and will pass the mutant gene to its entire offspring
Sample Requirements
Whole blood in EDTA tube (0.5 - 1 ml) or Buccal Swabs.
Turnaround
1 - 2 weeks
Price
£ 48.00 (including VAT)

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