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LABOKLIN (UK)| Genetic Diseases | Dogs| Ichthyosis ( Epidermolytic Hyperkeratosis (EHK) )
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Ichthyosis ( Epidermolytic Hyperkeratosis (EHK) )

Test number: 8311
Gene: KRT10
Price: £ 48.00 (including VAT)
Breed
Norfolk Terrier .
The Disease
Epidermolytic hyperkeratosis is an inherited skin disease characterised by fragile skin, hyperkeratosis, and hyperpigmentation.
Trait of Inheritance
.

Inheritance : AUTOSOMAL RECESSIVE trait


 

Sire

 

Dam

 

Offspring

         
clear
clear
100% clear
         
clear
carrier
50%  clear + 50% carriers
         
clear
affected
100% carriers
         
carrier
clear
50%  clear + 50% carriers
         
carrier
carrier
25% clear + 25% affected + 50% carriers
         
carrier
affected
50% carriers + 50% affected
         
affected
clear
100%  carriers
         
affected
carrier
50% carriers + 50% affected
         
affected
affected
100% affected

 


Clear

Genotype: N / N [ Homozygous normal ]

The dog is noncarrier of the mutant gene.

It is very unlikely that the dog will develop Ichthyosis ( Epidermolytic Hyperkeratosis (EHK) ). The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.

 

Carrier

Genotype: N / KRT10 [ Heterozygous ]

The dog carries one copy of the mutant gene and one copy of the normal gene.

It is very unlikely that the dog will develop Ichthyosis ( Epidermolytic Hyperkeratosis (EHK) ) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%.

Carriers should only be bred to clear dogs.

Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)

 

Affected

Genotype: KRT10 / KRT10 [ Homozygous mutant ]

 

The dog carries two copies of the mutant gene and therefore it will pass the mutant gene to its entire offspring.

The dog is likely to develop Ichthyosis ( Epidermolytic Hyperkeratosis (EHK) ) and will pass the mutant gene to its entire offspring
Sample Requirements
Whole blood in EDTA tube (0.5 - 1 ml) or Buccal Swabs.
Turnaround
1 - 2 weeks
Price
£ 48.00 (including VAT)

To order:




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