We apologize for any inconvenience caused by the internet outage in our area on Wednesday, 12th June 2024. Our website, email, and phone services were temporarily unavailable
between 9:30 am and 4:00 pm. We are pleased to inform you that the issue has been resolved, and all services are now back to normal. Thank you for your patience and understanding.


LABOKLIN (UK)| Genetic Diseases | Horses| IMM and MYH1 Myopathy ( MYHM ) *
prices in Pound
 
  Home
  News and offers
  Genetic Diseases
Dogs
Cats
Horses
Cattle
Pigs
Rabbit
Sheep
  Coat Colours / Length
  Identity / Parentage
  Reptiles & Amphibians
  Avian Tests
  Profiles / Screening
  Infectious Diseases
  Allergy testing
  Organs / Parameters
  Downloads & Order
  Order Kit Online
  About Us
  Crufts & Shows
  Contact Us
  Kennel Club ABS
  facebook
 
**NEW**



Maine Coon Special offer:
8 DNA tests for just £84.95 incl VAT
Maine Coon 8 DNA tests bundle (HCM, SMA, PKDef, Poly, b, b1, cb, cs) 
**NEW**



Bengal Special offer:
4 Bengal Specific DNA tests for just £72.00 incl VAT
Bengal DNA bundle (rdAc-PRA + b-PRA + PK-Def + Blood Groups) 



British Special offer:
4 Breed Specific DNA tests for just £72.00 incl VAT
British Short / Long Hair DNA bundle (PKD + pd-PRA + ALS + Blood Groups)



Burmese Special offer:
4 Breed Specific DNA tests for just £72.00 incl VAT
Burmese DNA bundle (Hypokalemia (BHK) + Head Defect + Gangliosidosis (GM2) + Blood Groups



Birman Special offer:
5 Breed Specific DNA tests for just £72.00 incl VAT
Birma DNA bundle (PKD + pd-PRA + Hypotrichiose + MPS6 + Blood Groups)



Maine Coon Special offer:
5 Breed Specific DNA tests for just £72.00 incl VAT
Maine Coon DNA bundle (HCM1 + SMA + PK-Def + F11 + Blood Groups)



Ragdoll Special offer:
5 Breed Specific DNA tests for just £72.00 incl VAT
Ragdoll DNA bundle (HCM1 + HCM3 + PKD + pd-PRA + Blood Groups)



Norwegian Special offer:
4 Breed Specific DNA tests for just £72.00 incl VAT
Norwegian Forest DNA bundle (PK-Def + Amber + GSD4 + Blood Groups)



Feline Special Offer:
8 cat DNA tests for just £84.95 including VAT
HCM, HCR, GSD4, PKD, PRA, PK-Def., SMA, Blood Groups

new test:      Paradoxical Pseudomyotonia (PP) in English Cocker and English Springer Spaniels  
new test:      Dyserythropoietic Anemia and Myopathy Syndrome (DAMS) in English Springer Spaniel
new test:      Lysosomal Storage Diseases (LSD) in Dalmatian and Doberman  
new Kennel Club DNA testing schemes with LABOKLIN:
   Osteochondrodysplasia (OCD) / Skeletal Dwarfism in Miniature Poodles
  DINGS2: Deafness with Vestibular Dysfunction in Doberman
   Dyserythropoietic Anemia and Myopathy Syndrome (DAMS) in English Springer Spaniel


IMM and MYH1 Myopathy ( MYHM ) *

Test number: 8293
Gene: MYHM
Price: £ 48.00 (including VAT)
Breeds
Appaloosas , Paint Horse , Quarter Horse (Horse with quarter horse blood) .
The Disease
Immune mediated Myositis & MYH1 Myopathy (IMM and MYH1 Myopathy)

Quarter Horse and related breeds are susceptible to developing rapidly progressing form of muscle atrophy and severe damage to muscles at rest known as nonexertional rhabdomyolysis. The severe atrophy can be caused by an autoimmune muscle disease called immune-mediated myositis (IMM), which can result in the loss of 40% of muscle mass within 72 hours in Quarter Horse and related breeds. The disease is characterized by infiltration of inflammatory cells, in particular the lymphocytes, into the muscles and surrounding the muscle blood vessels, with preference to target the rump and the muscles alongside the vertebral column. IMM is characterized by stiffness, weakness and nonspecific malaise. The disease affects either horses who are 8 years and younger or 17 years and older. IMM maybe triggered by factors such as Streptococcus equi subsp. equi infection, respiratory virus or vaccination with influenza, Equine Herpes Virus 4 or Streptococcus equi subsp. equi.

Researchers at Michigan State University and University of California-Davis identified a mutation in the Myosin Heavy Chain 1 (MYH1) gene that is associated with increased susceptibility to develop IMM in Quarter Horses and related breeds which is characterized by significant muscle atrophy. IMM and nonexertional rhabdomyolysis belong to the group of muscle diseases known as MYH1 myopathy (MYHM).

Trait of Inheritance
The mode of inheritance for MYHM is autosomal dominant with variable penetrance, which means that both males and females are affected and not all horses that have 1 (N/MYHM) or 2 copies (MYHM/MYHM) of the mutation will develop IMM or nonexertional rhabdomyolysis. Horses with two copies (MYHM/MYHM) may be more severely affected.

Inheritance : trait
Description

* tested by UC Davies

Sample Requirements
Hair Sample from mane with roots (approx 30 hairs) , Buccal Swabs or 1 ml whole blood in EDTA tube.

How to obtain a viable hair sample

Pull around 30 hairs from the mane of the horse with the roots (in faols hair from the tail maybe taken). Wrap the hairs around your finger or a comb, as close as possible to the skin to ensure you obtain the hair roots. Keep dry, put in a bag, label the bag with the horse name, test (s) required. Place in an envelope and send back to us together with the order form. Broken or cut off hair will not be accepted.
Turnaround
2-3 weeks
Price
£ 48.00 (including VAT)

To order:




new test:
Androgen Insensitivity Syndrome (AIS)
new test:
ACAN Dwarfism (Chondrodysplasia)
new test:
Predictive Height Test ( LCORL)
new test:

Tractability
new test:
Coat colour Sunshire Dilution



See also:

 
 
Home   |   Genetic Diseases  |   Coat Colours / Length  |   Identity / Parentage  |   Reptiles & Amphibians  |   Avian Tests  |   Profiles / Screening  |   Infectious Diseases  |   Allergy testing  |   Organs / Parameters  |   About us  |   Contact Us
LABOKLIN GmbH & Co. KG
ISO / DIN 17025 Accredited Laboratory
© 2007-2023 Laboklin (UK)
Unit 20, Wheel Forge Way, Trafford Park, Manchester, M17 1EH
Tel. 0161 282 3066