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LABOKLIN (UK)| Genetic Diseases | Horses| IMM and MYH1 Myopathy ( MYHM ) *
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IMM and MYH1 Myopathy ( MYHM ) *

Test number: 8293
Gene: MYHM
Price: £ 48.00 (including VAT)
Appaloosas , Paint Horse , Quarter Horse (Horse with quarter horse blood) .
The Disease
Immune mediated Myositis & MYH1 Myopathy (IMM and MYH1 Myopathy)

Quarter Horse and related breeds are susceptible to developing rapidly progressing form of muscle atrophy and severe damage to muscles at rest known as nonexertional rhabdomyolysis. The severe atrophy can be caused by an autoimmune muscle disease called immune-mediated myositis (IMM), which can result in the loss of 40% of muscle mass within 72 hours in Quarter Horse and related breeds. The disease is characterized by infiltration of inflammatory cells, in particular the lymphocytes, into the muscles and surrounding the muscle blood vessels, with preference to target the rump and the muscles alongside the vertebral column. IMM is characterized by stiffness, weakness and nonspecific malaise. The disease affects either horses who are 8 years and younger or 17 years and older. IMM maybe triggered by factors such as Streptococcus equi subsp. equi infection, respiratory virus or vaccination with influenza, Equine Herpes Virus 4 or Streptococcus equi subsp. equi.

Researchers at Michigan State University and University of California-Davis identified a mutation in the Myosin Heavy Chain 1 (MYH1) gene that is associated with increased susceptibility to develop IMM in Quarter Horses and related breeds which is characterized by significant muscle atrophy. IMM and nonexertional rhabdomyolysis belong to the group of muscle diseases known as MYH1 myopathy (MYHM).

Trait of Inheritance
The mode of inheritance for MYHM is autosomal dominant with variable penetrance, which means that both males and females are affected and not all horses that have 1 (N/MYHM) or 2 copies (MYHM/MYHM) of the mutation will develop IMM or nonexertional rhabdomyolysis. Horses with two copies (MYHM/MYHM) may be more severely affected.

Inheritance : trait

* tested by UC Davies

Sample Requirements
Hair Sample from mane with roots (approx 30 hairs) , Buccal Swabs or 1 ml whole blood in EDTA tube.

How to obtain a viable hair sample

Pull around 30 hairs from the mane of the horse with the roots (in faols hair from the tail maybe taken). Wrap the hairs around your finger or a comb, as close as possible to the skin to ensure you obtain the hair roots. Keep dry, put in a bag, label the bag with the horse name, test (s) required. Place in an envelope and send back to us together with the order form. Broken or cut off hair will not be accepted.
2-3 weeks
£ 48.00 (including VAT)

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