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Lethal Acrodematitis ( LAD )

Test number: 8273
Gene: MKLN1
Price: £ 48.00 (including VAT)
Breeds
Bull Terrier , Miniature Bull Terrier .
Trait of Inheritance
.

Inheritance : AUTOSOMAL RECESSIVE trait


 

Sire

 

Dam

 

Offspring

         
clear
clear
100% clear
         
clear
carrier
50%  clear + 50% carriers
         
clear
affected
100% carriers
         
carrier
clear
50%  clear + 50% carriers
         
carrier
carrier
25% clear + 25% affected + 50% carriers
         
carrier
affected
50% carriers + 50% affected
         
affected
clear
100%  carriers
         
affected
carrier
50% carriers + 50% affected
         
affected
affected
100% affected

 


Clear

Genotype: N / N [ Homozygous normal ]

The dog is noncarrier of the mutant gene.

It is very unlikely that the dog will develop Lethal Acrodematitis ( LAD ). The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.

 

Carrier

Genotype: N / MKLN1 [ Heterozygous ]

The dog carries one copy of the mutant gene and one copy of the normal gene.

It is very unlikely that the dog will develop Lethal Acrodematitis ( LAD ) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%.

Carriers should only be bred to clear dogs.

Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)

 

Affected

Genotype: MKLN1 / MKLN1 [ Homozygous mutant ]

 

The dog carries two copies of the mutant gene and therefore it will pass the mutant gene to its entire offspring.

The dog is likely to develop Lethal Acrodematitis ( LAD ) and will pass the mutant gene to its entire offspring
Description

Lethal Acrodematitis ( LAD ) is an inherited disease affecting the Bull Terriers and Miniature Bull Terriers breeds. The disease is characterised by poor growth, immune deficiency, and skin lesions, especially at the paws.Symptoms includ erythema and adherent scales on the the feet, elbows, hocks and muzzle. Hyperkeratosis of the foot pads is also seen. Immunodeficiency increases susceptibility to microbial infections including skin disease of the face and feet. Signs include stunting, splayed digits and eating difficulties. In older dogs, paronychia, nail disease and hyperkeratosis of the footpads develops, becoming severe in dogs over six months of age.

Puppies suffering from this condition have a greatly reduced lifespan due to infection, and they are often euthanized when the condition becomes very severe and painful.

The disease is caused by a mutation in the MKLN1 gene and a DNA test is now available at Laboklin.

Sample Requirements
Whole blood in EDTA tube (0.5 - 1 ml) or Buccal Swabs.
Turnaround
1-2 weeks
Price
£ 48.00 (including VAT)

To order:




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