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new test:      Paradoxical Pseudomyotonia (PP) in English Cocker and English Springer Spaniels  
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Juvenile Laryngeal Paralysis & Polyneuropathy (JLPP)

Test number: 8271
Gene: JLPP
Price: £ 48.00 (including VAT)
Breeds
Russian Black Terrier ( RBT ) , Rottweiler .
Kennel Club
This test is part of the Official UK Kennel Club DNA Testing Scheme in Russian Black Terrier ( RBT ), and Rottweiler.

for UK registered dogs, Laboklin can send results of the tests which are part of the Official UK Kennel Club DNA testing scheme to the Kennel Club (KC) to be recorded and published as part of the Kennel Club scheme. Results will only be recorded and published by the KC if the result report includes the dog’s microchip or tattoo number along with either the dog’s registered name or registered number. Any test results that do not carry these identifying features will not be recorded by the Kennel Club.

In order to ensure that test results are sent to the Kennel Club, customers must also sign the declaration section on the order form to give Laboklin permission to do so.

important: When you sign the declaration, Laboklin will send the results to the KC on your behalf, and you do not need to send them to the KC yourself again to avoid unnecessary duplications.

The Disease
Juvenile Laryngeal Paralysis & Polyneuropathy (JLPP) is a genetic disease that affects the nerves. In affected dogs, JLPP starts with the longest nerves in the body, one of the longest nerves is the one that supplies the muscles of the voice box (larynx) leading to muscle weakness and laryngeal paralysis as the first symptom. The vocal folds vibrate noisily and can obstruct the flow of air into the lungs when the dog is exercised or when it is hot. The dog may also choke on their food or water or regurgitate, and this can cause pneumonia.

The disease then progresses to the next longest nerves which supply the muscles of the back legs resulting in difficulty getting up and wobbly gait, the hind limbs are followed by the front limbs.

Other symptoms include abnormalities in eye development.

Symptoms typically start after weaning age.

Trait of Inheritance
Juvenile Laryngeal Paralysis & Polyneuropathy (JLPP) is inherited as autosomal recessive trait. The test enables breeders to identify their dogs as Clear (N/N), Carriers (N/JLPP), or Affected (JLPP/JLPP), and this helps breeders to avoid having affected puppies while maintaining the diversity of the gene pool.

Inheritance : AUTOSOMAL RECESSIVE trait


 

Sire

 

Dam

 

Offspring

         
clear
clear
100% clear
         
clear
carrier
50%  clear + 50% carriers
         
clear
affected
100% carriers
         
carrier
clear
50%  clear + 50% carriers
         
carrier
carrier
25% clear + 25% affected + 50% carriers
         
carrier
affected
50% carriers + 50% affected
         
affected
clear
100%  carriers
         
affected
carrier
50% carriers + 50% affected
         
affected
affected
100% affected

 


Clear

Genotype: N / N [ Homozygous normal ]

The dog is noncarrier of the mutant gene.

It is very unlikely that the dog will develop Juvenile Laryngeal Paralysis & Polyneuropathy (JLPP). The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.

 

Carrier

Genotype: N / JLPP [ Heterozygous ]

The dog carries one copy of the mutant gene and one copy of the normal gene.

It is very unlikely that the dog will develop Juvenile Laryngeal Paralysis & Polyneuropathy (JLPP) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%.

Carriers should only be bred to clear dogs.

Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)

 

Affected

Genotype: JLPP / JLPP [ Homozygous mutant ]

 

The dog carries two copies of the mutant gene and therefore it will pass the mutant gene to its entire offspring.

The dog is likely to develop Juvenile Laryngeal Paralysis & Polyneuropathy (JLPP) and will pass the mutant gene to its entire offspring
Sample Requirements
Buccal Swabs or 0.5 - 1 ml blood in EDTA Blood Tube
Turnaround
2 - 3 weeks
Price
£ 48.00 (including VAT)

To order:




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See also:

 
 
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