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Dandy-Walker-Like Malformation (DWLM) / Cerebellar Hypoplasia (CH)

Test number: 8260
Gene: DWLM
Price: £ 48.00 (including VAT)
Breed
Eurasier .
The Disease
Dandy-Walker-Like Malformation (DWLM)in Purebred Eurasier Dogs with Familial Non-Progressive Ataxia

DWLM is a genetic disorder found in Eurasier dogs characterised by non-progressive ataxia, symptoms have been noted in dogs at 5 – 6 weeks old. The severity of the ataxia varies between dogs, from mild truncal sway, mild lack of movement coordination, subtle dysmetric gait, imbalance and pelvic limb ataxia to severe cerebellar ataxia in puppies and episodic falling or rolling. Follow-up examinations in adult dogs showed improvement of the cerebellar ataxia and a still absent menace response. Epileptic seizures occurred in some dogs.

References: Inferior Cerebellar Hypoplasia Resembling a Dandy-Walker-Like Malformation in Purebred Eurasier Dogs with Familial Non-Progressive Ataxia: A Retrospective and Prospective Clinical Cohort Study Filipa Bernardino,1 Kai Rentmeister,2 Martin J. Schmidt,3 Andreas Bruehschwein,4 Kaspar Matiasek,5 Lara A. Matiasek,1 Alexander Lauda,1 Heinz A. Schoon,6 and Andrea Fischer1,* Fernando de Castro, Academic Editor

Trait of Inheritance
.

Inheritance : AUTOSOMAL RECESSIVE trait


 

Sire

 

Dam

 

Offspring

         
clear
clear
100% clear
         
clear
carrier
50%  clear + 50% carriers
         
clear
affected
100% carriers
         
carrier
clear
50%  clear + 50% carriers
         
carrier
carrier
25% clear + 25% affected + 50% carriers
         
carrier
affected
50% carriers + 50% affected
         
affected
clear
100%  carriers
         
affected
carrier
50% carriers + 50% affected
         
affected
affected
100% affected

 


Clear

Genotype: N / N [ Homozygous normal ]

The dog is noncarrier of the mutant gene.

It is very unlikely that the dog will develop Dandy-Walker-Like Malformation (DWLM) / Cerebellar Hypoplasia (CH). The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.

 

Carrier

Genotype: N / DWLM [ Heterozygous ]

The dog carries one copy of the mutant gene and one copy of the normal gene.

It is very unlikely that the dog will develop Dandy-Walker-Like Malformation (DWLM) / Cerebellar Hypoplasia (CH) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%.

Carriers should only be bred to clear dogs.

Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)

 

Affected

Genotype: DWLM / DWLM [ Homozygous mutant ]

 

The dog carries two copies of the mutant gene and therefore it will pass the mutant gene to its entire offspring.

The dog is likely to develop Dandy-Walker-Like Malformation (DWLM) / Cerebellar Hypoplasia (CH) and will pass the mutant gene to its entire offspring
Description

The disease is caused by a mutation the VLDLR-Gene

The disease is caused by a mutation the VLDLR-Gene

Sample Requirements
Buccal Swabs or 0.5 - 1 ml blood in EDTA Blood Tube
Turnaround
2 - 3 weeks
Price
£ 48.00 (including VAT)

To order:




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