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Breeds
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Finnish Lapphund
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Lapponian Herder
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Swedish Lapp Hund
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Kennel Club
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This test is part of the Official UK Kennel Club DNA Testing Scheme in Finnish Lapphund.
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The Disease |
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Pompe's disease or GSDII (Glycogen Storage Disease Type II) is caused by deficiency of the acid alpha-glucosidase enzyme which leads to accumulation of glycogen in the cells, and this results in abnormal glucose levels in tissues such as cardiac, skeletal, and smooth muscle.
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Clinical Signs |
Affected dogs suffer from vomiting, regurgitation, progressive muscle weakness, exercise intolerance and heart problems. Symptoms start at around seven month of age, affected dogs usually die around 1.5-2 years of age.
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Trait of Inheritance |
Autosomal recessive
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Inheritance : AUTOSOMAL
RECESSIVE
trait
Sire
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Dam
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Offspring
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clear
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clear
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100% clear
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clear
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carrier
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50% clear + 50%
carriers
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clear
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affected
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100% carriers
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carrier
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clear
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50% clear + 50%
carriers
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carrier
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carrier
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25% clear + 25% affected
+ 50% carriers
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carrier
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affected
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50% carriers + 50%
affected
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affected
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clear
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100% carriers
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affected
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carrier
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50% carriers + 50%
affected
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affected
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affected
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100% affected
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Clear
Genotype: N / N [ Homozygous normal ]
The dog is noncarrier of the mutant gene.
It is very unlikely that the dog will develop Pompe's Disease (Glycogen Storage Disease type II / GSDII). The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.
Carrier
Genotype: N / GSDII [ Heterozygous ]
The dog carries one copy of the mutant gene and one
copy of the normal gene.
It is very unlikely that the dog will develop Pompe's Disease (Glycogen Storage Disease type II / GSDII) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%. Carriers should only be bred to clear dogs. Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)
Affected
Genotype: GSDII / GSDII [ Homozygous mutant ]
The dog carries two copies of the mutant gene and
therefore it will pass the mutant gene to its entire offspring.
The dog is likely to develop Pompe's Disease (Glycogen Storage Disease type II / GSDII) and will pass the mutant gene to its entire offspring
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Sample Requirements |
Whole blood in EDTA tube (0.5 - 1 ml) or Buccal swabs. .
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Price
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£ 48.00 (including VAT)
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To order:
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Download
Order Form from this link 
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Complete the order form and send it together
with your samples to the following address:
Laboklin (UK), 125 Northenden Road, Manchester, M33 3HF
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