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Kennel Club
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This test is part of the Official UK Kennel Club DNA Testing Scheme in Pug.
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The Disease |
Pug dog encephalitis (PDE) also know as necrotizing meningoencephalitis (NME), is an inflammatory disorder of the central nervous system that is usually progressive and fatal, it is most commonly found in small dog breeds. Clinical Symptoms include seizures, depression, ataxia, abnormal gait and blindness.
PDE is an auto-immune disease which affects the
central nervous system. |
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Clinical Signs |
First symptoms usually appear at the age of six months to three years and include
disorientation, instability and seizures. Affected dogs hold their head tilted to one side
or shake their heads, they wobble, show an unsteady gait, stumble and fall. Some
walk in circles without being able to stop or scratch the head in an attempt to release
pressure and pain. Evenetually dementia and coma occur. Dogs with encephalitis die 3-6
months after the onset of symptoms. |
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Trait of Inheritance |
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the test result can be either N/N (Clear or non-carrier), N/PDE (Carrier of the mutation) or PDE/PDE (homozygous for the mutation) , however, this is not a diagnostic tests, it is a risk factor mutation, which means that dogs tested affected (PDE/PDE) for the mutation have a higher risk of developing the disease although they may not develop the disease. Clear and carrier dogs have lower risk.
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Inheritance : AUTOSOMAL
trait
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Sample Requirements |
Whole blood in EDTA tube (0.5 - 1 ml) or Buccal swabs. . |
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Price
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£ 48.00 (including VAT)
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| To order:
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Download
Order Form from this link 
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Complete the order form and send it together
with your samples to the following address:
Laboklin (UK), 125 Northenden Road, Manchester, M33 3HF
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