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Myostatin Mutation ("Bully" Whippet)/ Double Muscling

Test number: 8220 (this test number replaces the old 8220D)
Gene: MD
Price: £ 48.00 (including VAT)
Breed
Whippet .
The Disease
Myostatin deficiency is an inherited disorder that originally is due to a gene mutation, often referred to as the “bully gene”. Myostatin is a growth factor responsible for controlling the development of muscle fibres. When the myostatin-producing gene is unable to function properly, excess muscling develops. Inheriting two copies of the mutation (one from each parent) results in a whippet with almost twice the amount of normal muscling. Although whippets with one copy of the mutation apear normal but may be more muscular than whippets not carrying the mutation, there is no real way to tell whether a whippet carries the gene just by its appearance. Double-muscled whippets exist in several unrelated lines in North America and Europe and, although this problem is now small, it appears to be growing.
Trait of Inheritance
Myostatin Deficiency Is inherited as a autosomal recessive trait

Inheritance : AUTOSOMAL RECESSIVE trait


 

Sire

 

Dam

 

Offspring

         
clear
clear
100% clear
         
clear
carrier
50%  clear + 50% carriers
         
clear
affected
100% carriers
         
carrier
clear
50%  clear + 50% carriers
         
carrier
carrier
25% clear + 25% affected + 50% carriers
         
carrier
affected
50% carriers + 50% affected
         
affected
clear
100%  carriers
         
affected
carrier
50% carriers + 50% affected
         
affected
affected
100% affected

 


Clear

Genotype: N / N [ Homozygous normal ]

The dog is noncarrier of the mutant gene.

It is very unlikely that the dog will develop Myostatin Mutation ("Bully" Whippet)/ Double Muscling. The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.

 

Carrier

Genotype: N / MD [ Heterozygous ]

The dog carries one copy of the mutant gene and one copy of the normal gene.

It is very unlikely that the dog will develop Myostatin Mutation ("Bully" Whippet)/ Double Muscling but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%.

Carriers should only be bred to clear dogs.

Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)

 

Affected

Genotype: MD / MD [ Homozygous mutant ]

 

The dog carries two copies of the mutant gene and therefore it will pass the mutant gene to its entire offspring.

The dog is likely to develop Myostatin Mutation ("Bully" Whippet)/ Double Muscling and will pass the mutant gene to its entire offspring
Sample Requirements
Whole blood in EDTA tube (0.5 - 1 ml) or Buccal Swabs.
Turnaround
2 - 3 weeks
Price
£ 48.00 (including VAT)

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