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Brachyury (Bobtail Gene / Short Tail / T-Box)

Test number: 8219 (this test number replaces the old 8219D)
Gene: ST
Price: £ 48.00 (including VAT)
Breeds
Australian Shepherd , Australian Stumpy tail cattle Dog , Austrian Pinscher , Bourbonnais Pointer (Bourbonnais Pointing Dog) , Bouvier des Ardennes , Brazilian Terrier , Brittany ( Brittany Spaniel ) , Croatian Sheepdog , Danish Farm Dog , Jack Russell Terrier , Karelian Bear Dog , Miniature American Shepherd , Mudi , Polish Lowland sheepdog , Pyrenean Shepherd , Savoy Sheepdog , Schipperke , Spanish Water Dog , Spanish Waterdog , Swedish Farm Dog , Swedish Vallhund , Welsh Corgi .
Kennel Club
This test is part of the Official UK Kennel Club DNA Testing Scheme in Schipperke.

for UK registered dogs, Laboklin can send results of the tests which are part of the Official UK Kennel Club DNA testing scheme to the Kennel Club (KC) to be recorded and published as part of the Kennel Club scheme. Results will only be recorded and published by the KC if the result report includes the dog’s microchip or tattoo number along with either the dog’s registered name or registered number. Any test results that do not carry these identifying features will not be recorded by the Kennel Club.

In order to ensure that test results are sent to the Kennel Club, customers must also sign the declaration section on the order form to give Laboklin permission to do so.

important: When you sign the declaration, Laboklin will send the results to the KC on your behalf, and you do not need to send them to the KC yourself again to avoid unnecessary duplications.

Description

Bobtail gene: Brachyury / Anury (Bobtail Gene / Short Tail / T-Box)

The spine (or backbone) is made up of a series of small bones called vertebrae. The dog's tail is the last segment of the spine and it is made up of as many as 23 small vertebrae. Normal tail length and number of vertebrae varies considerably in dogs, however, the number within a breed will be the same or may vary by one or two.

Tail length depends on the number of the caudal vertebrae, which can vary significantly between individuals. The bones of the normal tail are bigger at the base and and gradually taper toward the tip, giving the impression of a point.

A natural bobtail is a dog's tail which grows unusually short or is missing completely due to a genetic mutation. A short tail with variable lengths is also referred to as Brachyury , and a complete lack of vertebrae is referred to as Anury In a bobtail, some of the vertebrae are missing; the end of the tail looks somewhat blunt.

The mutation that is responsible for the bobtail phenotype has been identified in many breeds (but not all bobtail breeds), the mutation is in the t-box gene, and a DNA test is available at Laboklin.

The trait of inheritance is autosomal dominant which means that when a dog inherits one copy of the mutation (heterozygous N/T) it will have a natural short tail. Dogs with two copies (homozygous T/T) of the T-Box gene die in womb and reabsorbed resulting in smaller litter size. If puppies are born with two copies of the T-Box, they will have severe anatomical defects including Spina Bifida, which are severe enough to require euthanasia.

The test also helps in identifying if a dog is docked or if it has a natural short tail.

Possible results:

  • N/N (Normal Homozygous for the normal allele): The dog has two copies of the normal gene and will have a normal tail.
  • N/T:(Heterozygous) The dog carries one copy of the normal gene and one copy of the mutant gene; the dog has a natural short tail. Heterozygous dogs can pass the mutation to their offspring with a probability of 50%.
  • T/T (Homozygous for the mutation) (T/T): does not exist and thought to be lethal.

Research found that there is no association between the bobtail mutation and the short tail phenotype in the following breeds:

  • Boston Terrier
  • English Bulldog
  • King Charles Spaniel
  • Miniature Schnauzer
  • Parson Russell Terrier
  • Rottweiler

 
Further reading
Ancestral T-Box Mutationhtml file
Sample Requirements
Whole blood in EDTA tube (0.5 - 1 ml) or Buccal Swabs.
Turnaround
2 - 3 weeks
Price
£ 48.00 (including VAT)

To order:




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See also:

 
 
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