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new test:      Paradoxical Pseudomyotonia (PP) in English Cocker and English Springer Spaniels  
new test:      Dyserythropoietic Anemia and Myopathy Syndrome (DAMS) in English Springer Spaniel
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Hereditary Nephritis / Samoyed Hereditary Glomerulopathy

Test number: 8192DS
Gene: HN
Price: £ 48.00 (including VAT)
Breed
Samoyed .
Kennel Club
This test is part of the Official UK Kennel Club DNA Testing Scheme in Samoyed.

for UK registered dogs, Laboklin can send results of the tests which are part of the Official UK Kennel Club DNA testing scheme to the Kennel Club (KC) to be recorded and published as part of the Kennel Club scheme. Results will only be recorded and published by the KC if the result report includes the dog’s microchip or tattoo number along with either the dog’s registered name or registered number. Any test results that do not carry these identifying features will not be recorded by the Kennel Club.

In order to ensure that test results are sent to the Kennel Club, customers must also sign the declaration section on the order form to give Laboklin permission to do so.

important: When you sign the declaration, Laboklin will send the results to the KC on your behalf, and you do not need to send them to the KC yourself again to avoid unnecessary duplications.

Trait of Inheritance
X-Chromosomal Dominant with Variable Penetrance

Inheritance : X-LINKED RECESSIVE trait

 

Sire

  Dam   Offspring
        Males   Females
clear
clear
100% clear
 
100% clear
             
clear
carrier
50%  clear + 50% affected
 
50%  clear + 50% carriers
             
clear
affected
100% affected
 
100% carriers
             
affected
clear
100%  clear
 
100%  carriers
             
affected
carrier
50% affected + 50% clear
 
50% affected + 50% carriers
             
affected
affected
100% affected
 
100% affected

 


Male:

Clear

Genotype: N [ normal ]

The dog is noncarrier of the mutant gene.

The dog will never develop Hereditary Nephritis / Samoyed Hereditary Glomerulopathy and therefore it can be used in breeding and should only be bred to clear females.

 

Affected

Genotype: HN [ mutant ]

 

The dog carries the mutant gene and will pass it its entire female offspring.

The dog will develop Hereditary Nephritis / Samoyed Hereditary Glomerulopathy and will pass the mutant gene to its entire female offspring

Female:

Clear

Genotype: N / N [ Homozygous normal ]

The dog is noncarrier of the mutant gene.

The dog will never develop Hereditary Nephritis / Samoyed Hereditary Glomerulopathy and therefore it can be used in breeding and should only be bred to clear females.

 

Carrier

Genotype: N / HN [ Heterozygous ]

The dog carries one copy of the mutant gene and one copy of the normal gene.

The dog will never develop Hereditary Nephritis / Samoyed Hereditary Glomerulopathy but since it carries the mutant gene, it can pass it on to its offspring.

 

Affected

Genotype: HN / HN [ Homozygous mutant ]

 

The dog carries two copies of the mutant gene and therefore it will pass the mutant gene to its entire offspring.

The dog will develop Hereditary Nephritis / Samoyed Hereditary Glomerulopathy and will pass the mutant gene to its entire female offspring
Description

Hereditary nephritis / glomerulonephropathy in Samoyed is a recessive, X-linked hereditary disease that affects young male dogs more severely than females. Affected males and females spontaneously develop proteinuria, but only males progress to renal failure. Affected male puppies usually show symptoms of the disease by 2 to 3 months of age. They start to lose weight noticeably and kidney function deteriorates rapidly, resulting in death by an early age (approximately 1 year). Females who carry the disease also lose weight and develop proteinuria between two and three months of age, but the disease is less severe and does not progresses to kidney failure.

Sample Requirements
Whole blood in EDTA tube (0.5 - 1 ml) or Buccal Swabs.
Turnaround
2 - 3 weeks
Price
£ 48.00 (including VAT)

To order:




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