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LABOKLIN (UK)| Genetic Diseases | Dogs| C3 Deficiency (Complement Component 3 deficiency)
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C3 Deficiency (Complement Component 3 deficiency)

Test number: 8184
Gene: C3
Price: £ 48.00 (including VAT)
Breed
Brittany ( Brittany Spaniel ) .
The Disease
C3 deficiency is an inherited disorder that causes severe immuodeficiency in the Brittany breed. The Complement Component C3 is a protein that plays important role in the immune system and therefore the dog's ability to prevent batecrial infections. The disease is commonly seen in puppies, symptoms include recurring bacterial infections, pneumonia, kidney disease, infection of the urinary tract and the uterine. The disease can lead to kidney failure and death. Affected puppies also have an increased risk of developing hereditary muscle disease (hereditary canine spinal muscular atrophy). Treatment with antibiotics helps but does not cure.
Trait of Inheritance
.

Inheritance : AUTOSOMAL RECESSIVE trait


 

Sire

 

Dam

 

Offspring

         
clear
clear
100% clear
         
clear
carrier
50%  clear + 50% carriers
         
clear
affected
100% carriers
         
carrier
clear
50%  clear + 50% carriers
         
carrier
carrier
25% clear + 25% affected + 50% carriers
         
carrier
affected
50% carriers + 50% affected
         
affected
clear
100%  carriers
         
affected
carrier
50% carriers + 50% affected
         
affected
affected
100% affected

 


Clear

Genotype: N / N [ Homozygous normal ]

The dog is noncarrier of the mutant gene.

It is very unlikely that the dog will develop C3 Deficiency (Complement Component 3 deficiency). The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.

 

Carrier

Genotype: N / C3 [ Heterozygous ]

The dog carries one copy of the mutant gene and one copy of the normal gene.

It is very unlikely that the dog will develop C3 Deficiency (Complement Component 3 deficiency) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%.

Carriers should only be bred to clear dogs.

Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)

 

Affected

Genotype: C3 / C3 [ Homozygous mutant ]

 

The dog carries two copies of the mutant gene and therefore it will pass the mutant gene to its entire offspring.

The dog is likely to develop C3 Deficiency (Complement Component 3 deficiency) and will pass the mutant gene to its entire offspring
Sample Requirements
Whole blood in EDTA tube (0.5 - 1 ml) or Buccal Swabs.
Turnaround
2 - 3 weeks
Price
£ 48.00 (including VAT)

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