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Breeds
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Airedale Terrier
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Alaskan Klee Kai
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Beagle
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Finnish Hound
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Giant Schnauzer
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Papillon (Continental Toy Spaniel )
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Scottish Deerhound
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Welsh Springer Spaniel
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Kennel Club
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This test is part of the Official UK Kennel Club DNA Testing Scheme in Beagle.
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The Disease |
Factor VII deficiency is a mild bleeding disorder caused by lack of factor VII (proconvertin) which plays a role in the blood clotting system. Affected dogs bruise easily and nosebleeds maybe seen. There is often prolonged bleeding after surgery or trauma and, in the cases of major surgical procedures or trauma, bleeding maybe severe.
The condition may go unnoticed for long time and discovered only when a surgery is performed or if the dog had an accident, in both cases increased bleeding will be noticed which can be difficult to control. Your vet will suspect a bleeding disorder. |
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Trait of Inheritance |
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Factor VII Deficiency follows an autosomal recessive mode of inheritance.
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Inheritance : AUTOSOMAL
RECESSIVE
trait
Sire
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Dam
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Offspring
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clear
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clear
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100% clear
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clear
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carrier
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50% clear + 50%
carriers
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clear
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affected
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100% carriers
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carrier
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clear
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50% clear + 50%
carriers
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carrier
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carrier
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25% clear + 25% affected
+ 50% carriers
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carrier
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affected
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50% carriers + 50%
affected
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affected
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clear
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100% carriers
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affected
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carrier
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50% carriers + 50%
affected
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affected
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affected
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100% affected
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Clear
Genotype: N / N [ Homozygous normal ]
The dog is noncarrier of the mutant gene.
It is very unlikely that the dog will develop Factor VII Deficiency. The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.
Carrier
Genotype: N / FVII [ Heterozygous ]
The dog carries one copy of the mutant gene and one
copy of the normal gene.
It is very unlikely that the dog will develop Factor VII Deficiency but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%. Carriers should only be bred to clear dogs. Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)
Affected
Genotype: FVII / FVII [ Homozygous mutant ]
The dog carries two copies of the mutant gene and
therefore it will pass the mutant gene to its entire offspring.
The dog is likely to develop Factor VII Deficiency and will pass the mutant gene to its entire offspring
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Description |
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Recently, the mutation responsible for this condition has been identified by Dr Urs Giger and researchers at the University of Pennsylvania. The test is now available at LABOKLIN. Factor VII deficiency follows a recessive trait of inheritance, the test identify a dog as affected (2 copies of the abnormal gene), clear (0 copies of the abnormal gene) or carrier (1 copy of the abnormal gene). Only affected dogs with two copies of the affected gene will develop the disease. Since this is am autosomal recessive condition, carrier dogs will not develop the disease but will pass the mutation to their offspring.
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Sample Requirements |
Whole blood in EDTA tube (0.5 - 1 ml) or Buccal swabs. . |
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Price
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£ 48.00 (including VAT)
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| To order:
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Download
Order Form from this link 
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Complete the order form and send it together
with your samples to the following address:
Laboklin (UK), 125 Northenden Road, Manchester, M33 3HF
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