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Dwarfism (Pituitary Dwarfism / Hypopituitarism)

Test number: 8142
Gene: DWARFISM
Price: £ 48.00 (including VAT)
Breeds
Czechoslovakian Wolfdog , German Shepherd , Karelian Bear Dog , Lapland Reindeer Dog , Lapponian Herder , Saarloos Wolfdog , Tibetan Terrier , White Swiss Shepherd ( Berger Blanc Suisse ) .
Kennel Club
This test is part of the Official UK Kennel Club DNA Testing Scheme in Tibetan Terrier.

for UK registered dogs, Laboklin can send results of the tests which are part of the Official UK Kennel Club DNA testing scheme to the Kennel Club (KC) to be recorded and published as part of the Kennel Club scheme. Results will only be recorded and published by the KC if the result report includes the dog’s microchip or tattoo number along with either the dog’s registered name or registered number. Any test results that do not carry these identifying features will not be recorded by the Kennel Club.

In order to ensure that test results are sent to the Kennel Club, customers must also sign the declaration section on the order form to give Laboklin permission to do so.

important: When you sign the declaration, Laboklin will send the results to the KC on your behalf, and you do not need to send them to the KC yourself again to avoid unnecessary duplications.

The Disease
Inherited Dwarfism is a condition in which the production of the Growth Hormone (GH) is inadequate. Growth hormone is secreted by the pituitary gland and has many effects on the body including control of growth rate, maintenance of hair coat, and bone and teeth development. Affected dogs appear normal at birth, but show evidence of failure to grow by two to three months of age. Symptoms include small stature compared to littermates, retention of puppy coat, hair loss, darkening of the skin, delayed eruption or absence of permanent teeth, a shrill bark, Small testicles and sometimes infertility in the male, Absence of heat and sometimes infertility in the female.

Please note that the mutation which causes Pituitary Dwarfism in Karelian Bear Dog and Lapponian Herder, is different from the mutation which causes Pituitary Dwarfism in German Shepherd, Saarlooswolfdog, Czechoslovakian Wolfdog, Tibetan Terrier and White Swiss Shepherd Dog. We will perform the correct test for the breed.

Clinical Signs
Affected dogs appear normal at birth, but show evidence of failure to grow by two to three months of age. Symptoms include small stature compared to littermates, retention of puppy coat, hair loss, darkening of the skin, delayed eruption or absence of permanent teeth, a shrill bark, Small testicles and sometimes infertility in the male, Absence of heat and sometimes infertility in the female.

Trait of Inheritance
Dwarfism follows an autosomal recessive mode of inheritance.

Inheritance : AUTOSOMAL RECESSIVE trait


 

Sire

 

Dam

 

Offspring

         
clear
clear
100% clear
         
clear
carrier
50%  clear + 50% carriers
         
clear
affected
100% carriers
         
carrier
clear
50%  clear + 50% carriers
         
carrier
carrier
25% clear + 25% affected + 50% carriers
         
carrier
affected
50% carriers + 50% affected
         
affected
clear
100%  carriers
         
affected
carrier
50% carriers + 50% affected
         
affected
affected
100% affected

 


Clear

Genotype: N / N [ Homozygous normal ]

The dog is noncarrier of the mutant gene.

It is very unlikely that the dog will develop Dwarfism (Pituitary Dwarfism / Hypopituitarism). The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.

 

Carrier

Genotype: N / DWARFISM [ Heterozygous ]

The dog carries one copy of the mutant gene and one copy of the normal gene.

It is very unlikely that the dog will develop Dwarfism (Pituitary Dwarfism / Hypopituitarism) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%.

Carriers should only be bred to clear dogs.

Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)

 

Affected

Genotype: DWARFISM / DWARFISM [ Homozygous mutant ]

 

The dog carries two copies of the mutant gene and therefore it will pass the mutant gene to its entire offspring.

The dog is likely to develop Dwarfism (Pituitary Dwarfism / Hypopituitarism) and will pass the mutant gene to its entire offspring
Description

By DNA testing, the responsible mutation can be shown directly. This method provides a test with a very high accuracy. It offers the possibility to distinguish not only between affected and clear dogs, but also to identify clinically healthy carriers. This is an essential information for controlling the condition in the breed, as carriers are able to spread the disease in the population.

test will be performed at a partner laboratory.

In German Shepherd, Saarloos, Czech Sheepdog and Tibetan terrier, we test for the mutation in the LHX3-gene, in Karelian Beardog and Lapponian Herder, we test for the mutation in the POU1F1 gene

Sample Requirements
0.5 to 1 ml blood in EDTA tube or Buccal Swabs
0.5 to 1 ml blood in EDTA tube or Buccal swabs .
Turnaround
2 - 3 weeks
Price
£ 48.00 (including VAT)

To order:




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See also:

 
 
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