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HCM, HCR, GSD4, PKD, PRA, PK-Def., SMA, Blood Groups

new test: Cocoa (Chocolate / Brown ) in French Bulldog
new test: Stargardt disease ( STGD )  and  Copper storage disease - Copper toxicosis (CT) in Labrador Retriever
new test: Inflammatory Pulmonary Disease ( IPD ) in Rough and Smooth Collies
new test: Lafora Disease in Basset Hound, Beagle, Chihuahua, French Bulldog, Welsh Corgi and Mini Wirehaired Dachshund
new Kennel Club DNA testing schemes with LABOKLIN:
• Pug Dog Encephalitis (PDE) / Necrotizing Meningoencephalitis (NME) in Pug
• Progressive Retinal Atrophy (prcd-PRA) and • Progressive retinal atrophy ( rcd4-PRA) / LOPRA in Standard Poodle
• Dwarfism ( Chondrodysplasia / disproportinate short-limbed ) and • Primary Open Angle Glaucoma (POAG) in Norwegian Elkhounds


Coat Colours: D-Locus D1 ( Dilution )

Test number: 8136

Breeds
All Dog Breeds , Border collie , Boston Terrier , Bulldog , Chihuahua , Doberman Pinscher , French Bull Dog , German Pinscher , Koolie ( Australian Koolie ) , Labrador Retriever , Large Munsterlander , Miniature Pinscher , Newfoundland , Rhodesian Ridgeback , Staffordshire Bull Terrier .
Description

The D locus is the primary locus associated with diluted pigment, which results in coats that would otherwise be black or brown instead showing up as gray, or blue in the case of black, and pale brown or Isabella in the case of brown. The melanophilin gene has recently been shown to be responsible, but not all of the dilute causing mutations have been identified yet.

A recessive mutation in the melanophilin gene was identified as the cause of colour dilution phenotypes in the dog. Two alleles (variants) are described: the dominant full colour (D) and the recessive dilute (d). Two copies of dilute are needed to lighten black pigment to grey (often called blue) and red pigment to cream (also called buff). A diagnostic DNA test identifies the specific variants of the MLPH gene.

Please note that in the Chow Chow, Thai Ridgeback and Sloughi breeds, there is another mutation that can cause coat colour dilution, it is the D2 Locus mutation and in those breeds both D1 Locus and D2 Locus mutations must be tested for complete analysis.

Please note that in the Chihuahua, Italian Greyhound and Hungarian Pumi breeds, there is another mutation that can cause coat colour dilution, it is the D3 Locus mutation and in those breeds both D 1Locus and D3 Locus mutations must be tested for complete analysis.

 
Further reading
Coat Colour Inheritance Chartshtml file
Sample Requirements
Whole blood in EDTA tube (0.5 - 1 ml) or Buccal Swabs.
Whole blood in EDTA tube (0.5 - 1 ml) or Buccal swabs. .
Turnaround
2 - 3 weeks
Price
Number of Coat Colour Tests on the same dog Price (including VAT)
First Colour test £ 48.00
Each additional colour test on the same dog £ 24.00

To order:

  • Download Order Form from this link pdf

  • Complete the order form and send it together with your samples to the following address:

    Laboklin (UK),   125 Northenden Road, Manchester, M33 3HF




new test:
Androgen Insensitivity Syndrome (AIS)
new test:
ACAN Dwarfism (Chondrodysplasia)
new test:
Predictive Height Test ( LCORL)
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Tractability
new test:
Coat colour Sunshire Dilution



See also:
Coat Colour: B Locus (bd, bc, bs) Brown Coat Colour  
Coat Colour: D- Locus ( Dilution ) rare variant D2 / D3  
Coat Colours: K- Locus  
Coat Colours: EM-Locus Melanistic Mask Allele (Em), E-Locus  
Curly Coat  
Furnishings and Improper Coat  
Coat Colour EG- Locus (domino, grizzle)  
Coat Colour: EH-locus (sable)  
Coat Colour: S-locus (piebald, spotted white)*  
Hairlessness  
Harlequin  
Saddle Tan  
Coat (hair) Length I  
Coat (hair) Length II  
Panda White Spotting  
C Locus (Albino, caL, OCA2)  
D Locus D1 + D2 ( Dilution )  
Coat Length I + II ( Long or Short Hair)  
Coat Colours: E-Locus E2 (Red / Yellow)  
M Locus * / Merle Gene / Dapple (merle / Cryptic Merle)  
Coat Colour DNA bundle: Loci A + B + D1 + E1 + I + K + S  
I - Locus (phaeomelanin intensity)  
Coat Colour: D3 - Locus ( Dilution )  
D Locus D1 + D3 ( Dilution )  
Shedding ( MC5R )  
Cocoa ( Brown / Chocolate ) in French Bulldog  
C-Locus (Albino) / Oculocutaneous Albinism Type 4 (OCA4)  
Coat Colour: B Locus (rare variants: b4 and be) Brown Coat Colour  
Coat Colours: E-Locus E1 (yellow, lemon, red, cream and appricot)  
E-Locus Special Colours ('eA', 'eG' and 'eH')(Hare-pid, Grizzle / Domino, Sable)  
Coat Colours: A-Locus Agouti ( fawn, sable, black and tan/tricolor, recessive black)  

 
 
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LABOKLIN GmbH & Co. KG
ISO / DIN 17025 Accredited Laboratory
© 2007 Laboklin (UK)
125 Northenden Road, Manchester, M33 3HF
Tel. 0161 282 3066