We apologize for any inconvenience caused by the internet outage in our area on Wednesday, 12th June 2024. Our website, email, and phone services were temporarily unavailable
between 9:30 am and 4:00 pm. We are pleased to inform you that the issue has been resolved, and all services are now back to normal. Thank you for your patience and understanding.

LABOKLIN (UK)| Genetic Diseases | Cats| HCM 1 (Hypertrophic Cardiomyopathy)
prices in Pound
  News and offers
  Genetic Diseases
  Coat Colours / Length
  Identity / Parentage
  Reptiles & Amphibians
  Avian Tests
  Profiles / Screening
  Infectious Diseases
  Allergy testing
  Organs / Parameters
  Downloads & Order
  Order Kit Online
  About Us
  Crufts & Shows
  Contact Us
  Kennel Club ABS

Maine Coon Special offer:
8 DNA tests for just £84.95 incl VAT
Maine Coon 8 DNA tests bundle (HCM, SMA, PKDef, Poly, b, b1, cb, cs) 

Bengal Special offer:
4 Bengal Specific DNA tests for just £72.00 incl VAT
Bengal DNA bundle (rdAc-PRA + b-PRA + PK-Def + Blood Groups) 

British Special offer:
4 Breed Specific DNA tests for just £72.00 incl VAT
British Short / Long Hair DNA bundle (PKD + pd-PRA + ALS + Blood Groups)

Burmese Special offer:
4 Breed Specific DNA tests for just £72.00 incl VAT
Burmese DNA bundle (Hypokalemia (BHK) + Head Defect + Gangliosidosis (GM2) + Blood Groups

Birman Special offer:
5 Breed Specific DNA tests for just £72.00 incl VAT
Birma DNA bundle (PKD + pd-PRA + Hypotrichiose + MPS6 + Blood Groups)

Maine Coon Special offer:
5 Breed Specific DNA tests for just £72.00 incl VAT
Maine Coon DNA bundle (HCM1 + SMA + PK-Def + F11 + Blood Groups)

Ragdoll Special offer:
5 Breed Specific DNA tests for just £72.00 incl VAT
Ragdoll DNA bundle (HCM1 + HCM3 + PKD + pd-PRA + Blood Groups)

Norwegian Special offer:
4 Breed Specific DNA tests for just £72.00 incl VAT
Norwegian Forest DNA bundle (PK-Def + Amber + GSD4 + Blood Groups)

Feline Special Offer:
8 cat DNA tests for just £84.95 including VAT
HCM, HCR, GSD4, PKD, PRA, PK-Def., SMA, Blood Groups

new test:      Paradoxical Pseudomyotonia (PP) in English Cocker and English Springer Spaniels  
new test:      Dyserythropoietic Anemia and Myopathy Syndrome (DAMS) in English Springer Spaniel
new test:      Lysosomal Storage Diseases (LSD) in Dalmatian and Doberman  
new Kennel Club DNA testing schemes with LABOKLIN:
   Osteochondrodysplasia (OCD) / Skeletal Dwarfism in Miniature Poodles
  DINGS2: Deafness with Vestibular Dysfunction in Doberman
   Dyserythropoietic Anemia and Myopathy Syndrome (DAMS) in English Springer Spaniel

HCM 1 (Hypertrophic Cardiomyopathy)

Test number: 8080
Gene: HCM 1 Mutation Meurs - A31P
Price: £ 48.00 (including VAT)
Maine Coon .
The Disease

HCM 1 (Hypertrophic Cardiomyopathy) Mutation Meurs A31P

Hypertrophic cardiomyopathy (HCM) is a clinically heterogeneous myocardial disease and is the most common cardiac disease identified in domestic cats.

HCM is characterised by an increased left ventricular mass due to an increase in wall thickness of the heart, with papillary muscle hypertrophy and systolic anterior motion of the Mitral valves.

Subsequently, hypertrophy of the left heart chamber results in cardiac weakness and ultimately in heart failure.

Death by HCM can occur via three mechanisms:

(i) sudden cardiac death with arrhythmia and ventricular fibrillation,

(ii) heart failure with tachycardia, increased respiration, shortness of breath, pulmonary oedema and pleural effusion or

(iii) thrombus formation. Thrombi can form either in the left atrium due to abnormal blood circulation or in the heart chamber itself due to severe hypertrophy and cardiac weakness.

Atrial thrombi can brake free and reach the arterial blood circuit, thereby often causing blood congestion at the branching of pelvic and crural arteries with paralysis of the hind legs. Echocardiographic examination has so far been the only diagnostic tool for this disease. However, it can only identify affected cats with some years of age, when they already present first symptoms of HCM.

Trait of Inheritance

HCM is inherited as a single autosomal dominant condition. Heterozygous animals show all clinical signs of disease and can not live normal lives. They are able to propagate mutations throughout the population. Generally, 50% of a HCM positive cats offspring will inherit HCM. Homozygously affected animals for HCM show more severe clinical symptoms and will pass the defect gene onto all of their offspring.

Recently, a mutation in the MYBPC gene which is suggested to cause HCM in cats was found by Dr. Kathryn Meurs (Washington State University, USA). This mutation was found in most HCM affected cats but not in cats which were tested free by means of echocardiographic techniques. In our laboratory, we were also able to identify this mutation in european cats with HCM.

Inheritance : AUTOSOMAL DOMINANT trait



  Dam   Offspring
Clear (N/N)
Clear (N/N)
100% Clear (N/N)
clear (N/N)
affected (N/HCM)
50%  Clear  (N/N) + 50% affected (N/HCM)
clear (N/N)
affected  (HCM/HCM)
100% affected (N/HCM)
affected (N/HCM)
Clear (N/N)
50%  Clear (N/N) + 50% affected (N/HCM)
affected (N/HCM)
affected (N/HCM)
25% clear (N/N) + 25% affected (HCM/HCM) + 50% affected (N/HCM)
affected (N/HCM)
affected (HCM/HCM)
50% affected (N/HCM)+ 50% affected (HCM/HCM)
affected  (HCM/HCM)
Clear (N/N)
100%  affected (N/HCM)
affected  HCM/HCM
affected (N/HCM)
50% affected (N/HCM)+ 50% affected  (HCM/HCM)
affected  (HCM/HCM)
affected  (HCM/HCM)
100% affected  (HCM/HCM)



Genotype: N / N [ Homozygous normal ]

The cat is noncarrier of the mutant gene.

The cat will never develop HCM 1 (Hypertrophic Cardiomyopathy) and therefore it can be used in breeding.



Affected cats can have one of two genotypes:

Genotype: N / HCM 1 Mutation Meurs - A31P [ Heterozygous affected]

Due to the dominant nature of this condition heterozygous cats are likely to develop HCM 1 (Hypertrophic Cardiomyopathy) and show its symptoms.

Genotype: HCM 1 Mutation Meurs - A31P / HCM 1 Mutation Meurs - A31P [ Homozygous affected ]

Homozygously affected cats are at very high risk of developing HCM 1 (Hypertrophic Cardiomyopathy) and showing its symptoms more severly than heterozygously affected cats.

It is not recommended to use affected cats in breeding

The cat will pass the mutant gene to its offspring

DNA test

By DNA testing the mutation can be shown directly. The testing is carried out by state of the art laboratory methods and therefore provides a very high accuracy. In general DNA tests can be done at any age.

The test can be applied to Maine Coon and Maine Coon related cats, which were cross bred to Maine Coons. With this test we can diagnose the reported mutation, but by no means we can report on the presence/absence of the disease (especially in breeds where the correlation of HCM disease and the cited mutation is not proven). The results that are transmitted contain the information on presence/absence of the G to C mutation in the MYBPC gene exon 3 in the sample of the cat examined. We want to point out that there is still a small possibility of other mutations causing HCM which are not identified so far.

Sample Requirements
Whole blood in EDTA tube (0.5 - 1 ml) or Buccal Swabs.
1 - 2 weeks
£ 48.00 (including VAT)

To order:

new test:
Androgen Insensitivity Syndrome (AIS)
new test:
ACAN Dwarfism (Chondrodysplasia)
new test:
Predictive Height Test ( LCORL)
new test:

new test:
Coat colour Sunshire Dilution

See also:

Home   |   Genetic Diseases  |   Coat Colours / Length  |   Identity / Parentage  |   Reptiles & Amphibians  |   Avian Tests  |   Profiles / Screening  |   Infectious Diseases  |   Allergy testing  |   Organs / Parameters  |   About us  |   Contact Us
ISO / DIN 17025 Accredited Laboratory
© 2007-2023 Laboklin (UK)
Unit 20, Wheel Forge Way, Trafford Park, Manchester, M17 1EH
Tel. 0161 282 3066