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Breeds
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Cavalier King Charles Spaniel
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Golden Retriever
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Norfolk Terrier
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The Disease |
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Muscular Dystrophy (MD) is a spontaneous, X-linked, progressively fatal disease of dogs and is also a homologue of Duchenne muscular dystrophy (DMD). Affected dogs show raised creatine kinase levels, muscle atrophy with contractures, hyaline myofiber degeneration with mineralization, endomysial and perimysial fibrosis with fatty infiltration, and cardiomyopathy.
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Trait of Inheritance |
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Muscular Dystrophy (MD) is transmitted as an X-chromosomal recessive trait. This means that a dog can be genetically clear (also called homozygous normal), heterozygous (carries one copy of the defective gene) or affected (carries two copies of the defective gene) concerning MD. Heterozygous male dogs and homozygous female dogs will get symptoms of this disease. Reliable information of dogs that do not carry disease genes (particularly female dogs) is the key to control this disease.
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Inheritance : X-LINKED
RECESSIVE
trait
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Sire |
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Dam |
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Offspring |
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Males |
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Females |
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clear
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clear
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100% clear
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100% clear
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clear
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carrier
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50% clear + 50%
affected
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50% clear + 50%
carriers
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clear
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affected
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100% affected
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100% carriers
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affected
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clear
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100% clear
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100% carriers
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affected
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carrier
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50% affected + 50% clear
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50% affected + 50%
carriers
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affected
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affected
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100% affected
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100% affected
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Male:
Clear
Genotype: N [ normal ]
The dog is noncarrier of the mutant gene.
The dog will never develop Muscular Dystrophy (MD) and therefore it can be used in breeding and should only be bred to clear females.
Affected
Genotype: MD [ mutant ]
The dog carries the mutant gene and will pass it its entire female offspring.
The dog will develop Muscular Dystrophy (MD) and will pass the mutant gene to its entire female offspring
Female:
Clear
Genotype: N / N [ Homozygous normal ]
The dog is noncarrier of the mutant gene.
The dog will never develop Muscular Dystrophy (MD) and therefore it can be used in breeding and should only be bred to clear females.
Carrier
Genotype: N / MD [ Heterozygous ]
The dog carries one copy of the mutant gene and one
copy of the normal gene.
The dog will never develop Muscular Dystrophy (MD) but since it carries the mutant gene, it can pass it on to its offspring.
Affected
Genotype: MD / MD [ Homozygous mutant ]
The dog carries two copies of the mutant gene and
therefore it will pass the mutant gene to its entire offspring.
The dog will develop Muscular Dystrophy (MD) and will pass the mutant gene to its entire female offspring
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Description |
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This is a mutation-based gene test, which offers many advantages over other methods
The genetic defect leading to the disease has been identified. By DNA testing, the responsible mutation can be shown directly. This method provides a very high accuracy test and can be done at any age. It offers the possibility to distinguish between affected and clear dogs. This is an essential information for controlling the disease in the breed, as carriers are able to spread the disease in the population, but can not be identified by means of common laboratory diagnostic.
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Sample Requirements |
Whole blood in EDTA tube (0.5 - 1 ml) or Buccal swabs. . |
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Price
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£ 48.00 (including VAT)
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| To order:
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Download
Order Form from this link 
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Complete the order form and send it together
with your samples to the following address:
Laboklin (UK), 125 Northenden Road, Manchester, M33 3HF
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