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LABOKLIN (UK)| Genetic Diseases | Dogs| X-Linked Severe Combined Immunodeficiency (X-SCID)
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X-Linked Severe Combined Immunodeficiency (X-SCID)

Test number: 8063
Gene: X-SCID
Price: £ 48.00 (including VAT)
Breeds
Basset Hound , Welsh Corgi .
The Disease
The X-linked inherited disease is characterised by profound defects in cellular and humoral immunity and is inevitably fatal by 4 months of age.
Trait of Inheritance
X-SCID is inherited as an X-Linked recessive trait.

Inheritance : X-LINKED RECESSIVE trait

 

Sire

  Dam   Offspring
        Males   Females
clear
clear
100% clear
 
100% clear
             
clear
carrier
50%  clear + 50% affected
 
50%  clear + 50% carriers
             
clear
affected
100% affected
 
100% carriers
             
affected
clear
100%  clear
 
100%  carriers
             
affected
carrier
50% affected + 50% clear
 
50% affected + 50% carriers
             
affected
affected
100% affected
 
100% affected

 


Male:

Clear

Genotype: N [ normal ]

The dog is noncarrier of the mutant gene.

The dog will never develop X-Linked Severe Combined Immunodeficiency (X-SCID) and therefore it can be used in breeding and should only be bred to clear females.

 

Affected

Genotype: X-SCID [ mutant ]

 

The dog carries the mutant gene and will pass it its entire female offspring.

The dog will develop X-Linked Severe Combined Immunodeficiency (X-SCID) and will pass the mutant gene to its entire female offspring

Female:

Clear

Genotype: N / N [ Homozygous normal ]

The dog is noncarrier of the mutant gene.

The dog will never develop X-Linked Severe Combined Immunodeficiency (X-SCID) and therefore it can be used in breeding and should only be bred to clear females.

 

Carrier

Genotype: N / X-SCID [ Heterozygous ]

The dog carries one copy of the mutant gene and one copy of the normal gene.

The dog will never develop X-Linked Severe Combined Immunodeficiency (X-SCID) but since it carries the mutant gene, it can pass it on to its offspring.

 

Affected

Genotype: X-SCID / X-SCID [ Homozygous mutant ]

 

The dog carries two copies of the mutant gene and therefore it will pass the mutant gene to its entire offspring.

The dog will develop X-Linked Severe Combined Immunodeficiency (X-SCID) and will pass the mutant gene to its entire female offspring
Description

This is a mutation-based gene test, which offers many advantages over other methods

The genetic defect leading to the disease has been identified. By DNA testing, the responsible mutation can be shown directly. This method provides a very high accuracy test and can be done at any age. It offers the possibility to distinguish not only between affected and clear dogs, but also to identify clinically healthy carriers. This is an essential information for controlling the disease in the breed, as carriers are able to spread the disease in the population, but can not be identified by means of common laboratory diagnostic.

Sample Requirements
Whole blood in EDTA tube (0.5 - 1 ml) or Buccal Swabs.
Turnaround
2 - 3 weeks
Price
£ 48.00 (including VAT)

To order:




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See also:

 
 
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