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Breeds
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Basset Hound
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Welsh Corgi
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The Disease |
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The X-linked inherited disease is characterised by profound defects in cellular and humoral immunity and is inevitably fatal by 4 months of age.
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Trait of Inheritance |
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X-SCID is inherited as an X-Linked recessive trait.
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Inheritance : X-LINKED
RECESSIVE
trait
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Sire |
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Dam |
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Offspring |
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Males |
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Females |
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clear
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clear
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100% clear
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100% clear
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clear
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carrier
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50% clear + 50%
affected
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50% clear + 50%
carriers
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clear
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affected
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100% affected
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100% carriers
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affected
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clear
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100% clear
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100% carriers
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affected
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carrier
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50% affected + 50% clear
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50% affected + 50%
carriers
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affected
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affected
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100% affected
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100% affected
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Male:
Clear
Genotype: N [ normal ]
The dog is noncarrier of the mutant gene.
The dog will never develop X-Linked Severe Combined Immunodeficiency (X-SCID) and therefore it can be used in breeding and should only be bred to clear females.
Affected
Genotype: X-SCID [ mutant ]
The dog carries the mutant gene and will pass it its entire female offspring.
The dog will develop X-Linked Severe Combined Immunodeficiency (X-SCID) and will pass the mutant gene to its entire female offspring
Female:
Clear
Genotype: N / N [ Homozygous normal ]
The dog is noncarrier of the mutant gene.
The dog will never develop X-Linked Severe Combined Immunodeficiency (X-SCID) and therefore it can be used in breeding and should only be bred to clear females.
Carrier
Genotype: N / X-SCID [ Heterozygous ]
The dog carries one copy of the mutant gene and one
copy of the normal gene.
The dog will never develop X-Linked Severe Combined Immunodeficiency (X-SCID) but since it carries the mutant gene, it can pass it on to its offspring.
Affected
Genotype: X-SCID / X-SCID [ Homozygous mutant ]
The dog carries two copies of the mutant gene and
therefore it will pass the mutant gene to its entire offspring.
The dog will develop X-Linked Severe Combined Immunodeficiency (X-SCID) and will pass the mutant gene to its entire female offspring
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Description |
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This is a mutation-based gene test, which offers many advantages over other methods
The genetic defect leading to the disease has been identified. By DNA testing, the responsible mutation can be shown directly. This method provides a very high accuracy test and can be done at any age. It offers the possibility to distinguish not only between affected and clear dogs, but also to identify clinically healthy carriers. This is an essential information for controlling the disease in the breed, as carriers are able to spread the disease in the population, but can not be identified by means of common laboratory diagnostic.
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Price
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£ 48.00 (including VAT)
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