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MH (Malignant Hyperthermia)
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The Disease |
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Maligant hyperthermia (MH) is an inherited disorder of skeletal muscle characterized by hypercarbia, rhabdomyolysis, generalized skeletal muscle contracture, cardiac dysrhythmia, and renal failure, that develops on exposure to succinylcholine or volatile anesthetic agents. Specific interventions, including use of the calcium release channel antagonist dantrolene, are efficacious in reversing signs of the canine syndrome.
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Trait of Inheritance |
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Maligant hyperthermia is transmitted as an autosomal dominant trait. This means that a dog can be genetically clear (also called homozygous normal), heterozygous (carries one copy of the defective gene) or affected (carries two copies of the defective gene) concerning MH. Reliable information of dogs that do not carry disease genes is the key to controlling this disease.
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Inheritance : AUTOSOMAL
DOMINANT
trait
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Sire |
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Dam |
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Offspring |
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Clear
(N/N)
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x |
Clear
(N/N)
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> |
100% Clear
(N/N)
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clear
(N/N)
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x |
affected
(N/MH)
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> |
50% Clear
(N/N) + 50%
affected (N/MH)
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clear
(N/N)
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x |
affected
(MH/MH)
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> |
100% affected
(N/MH)
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affected
(N/MH)
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x |
Clear
(N/N)
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> |
50% Clear
(N/N) + 50%
affected (N/MH)
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affected
(N/MH)
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x |
affected
(N/MH)
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> |
25% clear
(N/N) + 25% affected
(MH/MH)
+ 50% affected (N/MH)
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affected
(N/MH)
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x |
affected
(MH/MH)
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> |
50% affected
(N/MH)+ 50%
affected (MH/MH)
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affected
(MH/MH)
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x |
Clear
(N/N)
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> |
100% affected
(N/MH)
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affected
MH/MH
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x |
affected
(N/MH)
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> |
50% affected
(N/MH)+ 50%
affected (MH/MH)
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affected
(MH/MH)
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x |
affected
(MH/MH)
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> |
100% affected
(MH/MH)
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Clear
Genotype: N / N [ Homozygous normal ]
The dog is noncarrier of the mutant gene.
The dog will never develop MH (Malignant Hyperthermia) and therefore it can be used in breeding.
Affected
Affected dogs can have one of two genotypes:
Genotype: N / MH [ Heterozygous affected], or
Genotype: MH / MH [ Homozygous affected ]
It is not recommended to use affected dogs in breeding
The dog will develop MH (Malignant Hyperthermia) and will pass the mutant gene to its offspring
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Description |
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This is a mutation-based gene test, which offers many advantages over other methods
The genetic defect leading to the disease has been identified. By DNA testing, the responsible mutation can be shown directly. This method provides a very high accuracy test and can be done at any age. It offers the possibility to distinguish between affected and clear dogs. This is an essential information for controlling the disease in the breed, as carriers are able to spread the disease in the population, but can not be identified by means of common laboratory diagnostic.
If a particularly valuable dog turns out to be a carrier, it can be bred to a non-affected animal, and non-carrier puppies can be saved for the next round of breeding.
Another great advantage of the genetic testing is the risk estimate before a narcosis.
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Sample Requirements |
Whole blood in EDTA tube (0.5 - 1 ml) or Buccal swabs. . |
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Price
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£ 48.00 (including VAT)
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| To order:
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Download
Order Form from this link 
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Complete the order form and send it together
with your samples to the following address:
Laboklin (UK), 125 Northenden Road, Manchester, M33 3HF
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