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LABOKLIN (UK)| Genetic Diseases | Dogs| MH (Malignant Hyperthermia)
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MH (Malignant Hyperthermia)

Test number: 8062
Gene: MH
Price: £ 48.00 (including VAT)
Breed
All Dog Breeds .
The Disease
Malignant hyperthermia (MH) is an inherited disorder of Malignant hyperthermia (MH) is a pharmacogenetic disorder that manifests upon exposure to volatile anesthetics and depolarizing muscle relaxants.

It is characterized by hypercarbia, rhabdomyolysis, generalized skeletal muscle contracture, cardiac dysrhythmia, and renal failure, which develop on exposure to succinylcholine or volatile anesthetic agents. Symptoms of malignant hyperthermia (MH) in dogs include tachycardia, hyperthermia, elevated carbon dioxide production, and can lead to death if the anesthetic is not discontinued.

The canine syndrome can be treated with specific interventions, such as the use of the calcium release channel antagonist dantrolene, which has been shown to be effective in reversing signs of MH. In most reports of MH in dogs, metabolic acidosis is moderate and muscle rigidity is minimal, in contrast to the severity of both in the swine or human condition.

Trait of Inheritance
Maligant hyperthermia is transmitted as an autosomal dominant trait. This means that a dog can be genetically clear (also called homozygous normal), heterozygous affected (carries one copy of the defective gene) or homozygous affected (carries two copies of the defective gene) concerning MH. Reliable information of dogs that do not carry disease genes is the key to controlling this disease.

Inheritance : AUTOSOMAL DOMINANT trait

 

Sire

  Dam   Offspring
         
Clear (N/N)
x
Clear (N/N)
>
100% Clear (N/N)
         
clear (N/N)
x
affected (N/MH)
>
50%  Clear  (N/N) + 50% affected (N/MH)
         
clear (N/N)
x
affected  (MH/MH)
>
100% affected (N/MH)
         
affected (N/MH)
x
Clear (N/N)
>
50%  Clear (N/N) + 50% affected (N/MH)
         
affected (N/MH)
x
affected (N/MH)
>
25% clear (N/N) + 25% affected (MH/MH) + 50% affected (N/MH)
         
affected (N/MH)
x
affected (MH/MH)
>
50% affected (N/MH)+ 50% affected (MH/MH)
         
affected  (MH/MH)
x
Clear (N/N)
>
100%  affected (N/MH)
         
affected  MH/MH
x
affected (N/MH)
>
50% affected (N/MH)+ 50% affected  (MH/MH)
         
affected  (MH/MH)
x
affected  (MH/MH)
>
100% affected  (MH/MH)

 


Clear

Genotype: N / N [ Homozygous normal ]

The dog is noncarrier of the mutant gene.

The dog will never develop MH (Malignant Hyperthermia) and therefore it can be used in breeding.

 

Affected

Affected dogs can have one of two genotypes:

Genotype: N / MH [ Heterozygous affected], or

Genotype: MH / MH [ Homozygous affected ]

 

It is not recommended to use affected dogs in breeding

The dog will develop MH (Malignant Hyperthermia) and will pass the mutant gene to its offspring
Sample Requirements
Whole blood in EDTA tube (0.5 - 1 ml) or Buccal Swabs.
Turnaround
2 - 3 weeks
Price
£ 48.00 (including VAT)

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