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Lafora Disease (LAF / LD) / Myoclonic Epilepsy
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Breeds
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Basset
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Beagle
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Cardigan Welsh Corgi
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Chihuahua
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French Bull Dog
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Miniature Wire haired Dachshund
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Newfoundland
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Pembroke Welsh Corgi
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Kennel Club
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This test is part of the Official UK Kennel Club DNA Testing Scheme in Beagle , and Miniature Wire haired Dachshund.
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The Disease |
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Lafora disease (LD) / Myoclonic Epilepsy is a late onset inherited neurological disorder affecting a number of breeds including Beagle and Miniature Wirehaired Dachshund ( MWHD ). Symptoms starts after the age of 5 years and include a characteristic quick and involuntary jerking of the head backward ( myoclonus ), which can occur spontaneously or triggered by noise, light flashing or flickering, jaw smacking, panic attacks, impaired vision, aggression and urinary incontinence. High pitched vocalisations have been seen in affected dogs. Symptoms can progress to epilepsy and seizures.
The disease is caused by a mutation which causes intracellular accumulation of abnormal glycogen (Lafora bodies).
Age of onset: after 5 years of ages
At the moment we only accept blood in EDTA blood tubes for this test. We cannot accept swabs at this time. |
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Trait of Inheritance |
Recessive trait of inheritance, which means that a dog must inherit two copies of the mutation (one from each parent) to become genetically affected. |
Inheritance : AUTOSOMAL
RECESSIVE
trait
Sire
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Dam
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Offspring
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clear
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clear
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100% clear
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clear
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carrier
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50% clear + 50%
carriers
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clear
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affected
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100% carriers
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carrier
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clear
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50% clear + 50%
carriers
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carrier
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carrier
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25% clear + 25% affected
+ 50% carriers
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carrier
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affected
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50% carriers + 50%
affected
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affected
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clear
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100% carriers
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affected
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carrier
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50% carriers + 50%
affected
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affected
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affected
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100% affected
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Clear
Genotype: N / N [ Homozygous normal ]
The dog is noncarrier of the mutant gene.
It is very unlikely that the dog will develop Lafora Disease (LAF / LD) / Myoclonic Epilepsy. The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.
Carrier
Genotype: N / LAF [ Heterozygous ]
The dog carries one copy of the mutant gene and one
copy of the normal gene.
It is very unlikely that the dog will develop Lafora Disease (LAF / LD) / Myoclonic Epilepsy but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%. Carriers should only be bred to clear dogs. Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)
Affected
Genotype: LAF / LAF [ Homozygous mutant ]
The dog carries two copies of the mutant gene and
therefore it will pass the mutant gene to its entire offspring.
The dog is likely to develop Lafora Disease (LAF / LD) / Myoclonic Epilepsy and will pass the mutant gene to its entire offspring
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Sample Requirements |
Whole blood in EDTA tube (0.5 - 1 ml) Whole blood in EDTA tube (0.5 - 1 ml) . |
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Price
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£ 96.00 (including VAT)
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| To order:
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Download
Order Form from this link 
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Complete the order form and send it together
with your samples to the following address:
Laboklin (UK), 125 Northenden Road, Manchester, M33 3HF
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