prices in Pound
 
  Home
  News and offers
  Genetic Diseases
Dogs
Cats
Horses
Cattle
Pigs
Sheep
  Coat Colours / Length
  Identity / Parentage
  Reptiles & Amphibians
  Avian Tests
  Profiles / Screening
  Infectious Diseases
  Organs / Parameters
  Downloads & Order
  Order Online
  About Us
  Crufts & Shows
  Contact Us
  Kennel Club ABS
  facebook
 
**NEW**



Bengal Special offer:
3 Bengal Specific DNA tests for just £60.00 incl VAT
Bengal DNA bundle (rdAc-PRA + b-PRA + PK-Def) 



British Special offer:
3 Breed Specific DNA tests for just £60.00 incl VAT
British Short / Long Hair DNA bundle (PKD + pd-PRA + ALS)



Burmese Special offer:
3 Breed Specific DNA tests for just £66.00 incl VAT
Burmese DNA bundle (Hypokalemia (BHK) + Head Defect + Gangliosidosis (GM2)



Birman Special offer:
4 Breed Specific DNA tests for just £66.00 incl VAT
Birma DNA bundle (PKD + pd-PRA + Hypotrichiose + MPS6)



Maine Coon Special offer:
3 Breed Specific DNA tests for just £60.00 incl VAT
Maine Coon DNA bundle (HCM1 + SMA + PK-Def)



Ragdoll Special offer:
4 Breed Specific DNA tests for just £60.00 incl VAT
Ragdoll DNA bundle (HCM1 + HCM3 + PKD + pd-PRA)



Norwegian Special offer:
3 Breed Specific DNA tests for just £60.00 incl VAT
Norwegian Forest DNA bundle (PK-Def + Amber + GSD4)



Feline Special Offer:
8 cat DNA tests for just £79.95 including VAT
HCM, HCR, GSD4, PKD, PRA, PK-Def., SMA, Blood Groups

new test: Cocoa (Chocolate / Brown ) in French Bulldog
new test: Stargardt disease ( STGD )  and  Copper storage disease - Copper toxicosis (CT) in Labrador Retriever
new test: Inflammatory Pulmonary Disease ( IPD ) in Rough and Smooth Collies
new test: Lafora Disease in Basset Hound, Beagle, Chihuahua, French Bulldog, Welsh Corgi and Mini Wirehaired Dachshund
new Kennel Club DNA testing schemes with LABOKLIN:
• Pug Dog Encephalitis (PDE) / Necrotizing Meningoencephalitis (NME) in Pug
• Progressive Retinal Atrophy (prcd-PRA) and • Progressive retinal atrophy ( rcd4-PRA) / LOPRA in Standard Poodle
• Dwarfism ( Chondrodysplasia / disproportinate short-limbed ) and • Primary Open Angle Glaucoma (POAG) in Norwegian Elkhounds


Progressive Retinal Atrophy (Dominant PRA)

Test number: 8002

PRA

Breeds
Bull Mastiff , English Mastiff .
The Disease
Progressive retinal atrophy (PRA) is a leading hereditary cause of blindness in pedigree dogs as is its counterpart retinitis pigmentosa (RP) in humans. PRA shows genetic heterogeneity, as does RP, with several distinct forms already recognized and several more remaining to be investigated. Pups show signs of night-blindness by 6 weeks of age. By the age of 1-2 years most affected dogs are completely blind.
Trait of Inheritance
Mastiffs and Bullmastiffs exhibit the first, and so far, only form of canine Progressive Retinal Atrophy - PRA - that is inherited as a dominant trait. Therefore only affected or unaffected dogs can be found. The Mastiffs are affected by the late onset form of the PRA. Since vision loss might be recognised first when the dog is several years old, it is important to determine the actual status of the dog before breeding it.

Inheritance : AUTOSOMAL DOMINANT trait

 

Sire

  Dam   Offspring
         
Clear (N/N)
x
Clear (N/N)
>
100% Clear (N/N)
         
clear (N/N)
x
affected (N/PRA)
>
50%  Clear  (N/N) + 50% affected (N/PRA)
         
clear (N/N)
x
affected  (PRA/PRA)
>
100% affected (N/PRA)
         
affected (N/PRA)
x
Clear (N/N)
>
50%  Clear (N/N) + 50% affected (N/PRA)
         
affected (N/PRA)
x
affected (N/PRA)
>
25% clear (N/N) + 25% affected (PRA/PRA) + 50% affected (N/PRA)
         
affected (N/PRA)
x
affected (PRA/PRA)
>
50% affected (N/PRA)+ 50% affected (PRA/PRA)
         
affected  (PRA/PRA)
x
Clear (N/N)
>
100%  affected (N/PRA)
         
affected  PRA/PRA
x
affected (N/PRA)
>
50% affected (N/PRA)+ 50% affected  (PRA/PRA)
         
affected  (PRA/PRA)
x
affected  (PRA/PRA)
>
100% affected  (PRA/PRA)

 


Clear

Genotype: N / N [ Homozygous normal ]

The dog is noncarrier of the mutant gene.

The dog will never develop Progressive Retinal Atrophy (Dominant PRA) and therefore it can be used in breeding.

 

Affected

Affected dogs can have one of two genotypes:

Genotype: N / PRA [ Heterozygous affected], or

Genotype: PRA / PRA [ Homozygous mutant ]

 

It is not recommended to use affected dogs in breeding

The dog will develop Progressive Retinal Atrophy (Dominant PRA) and will pass the mutant gene to its offspring
Description

This is a mutation-based gene test, which offers many advantages over other methods

Progress in molecular genetics has allowed the identification of the gene mutation responsible for PRA in the Bull and English Mastiff. By DNA testing, the responsible mutation can be shown directly. This method provides a very high accuracy test and can be done at any age. It offers the possibility to distinguish between affected and clear dogs. This is an essential information for controlling the disease in the breed.

Sample Requirements
Whole blood in EDTA tube (0.5 - 1 ml) or Buccal Swabs.
Whole blood in EDTA tube (0.5 - 1 ml) or Buccal swabs. .
Turnaround
2 - 3 weeks
Price
£ 48.00 (including VAT)

To order:

  • Download Order Form from this link pdf

  • Complete the order form and send it together with your samples to the following address:

    Laboklin (UK),   125 Northenden Road, Manchester, M33 3HF




new test:
Androgen Insensitivity Syndrome (AIS)
new test:
ACAN Dwarfism (Chondrodysplasia)
new test:
Predictive Height Test ( LCORL)
new test:

Tractability
new test:
Coat colour Sunshire Dilution



See also:
Copper Toxicosis (Copper Storage Disease )  
Globoid Cell Leukodystrophy (Krabbe Disease)  
CSNB (Congenital Stationary Night Blindness)  
CLAD (Canine Leukocyte Adhesion Deficiency)  
Cystinuria  
von Willebrand disease Type II (vWD II)  
PK Deficiency (Pyruvate Kinase Deficiency)  
Fucosidosis  
PFK Deficiency (Phosphofructokinase deficiency)  
Myotonia Congenita  
MH (Malignant Hyperthermia)  
X-Linked Severe Combined Immunodeficiency (X-SCID)  
GM1-Gangliosidosis  
Narcolepsy  
Muscular Dystrophy (MD)  
MPS ( Mucopolysaccharidosis type VII)  
Hereditary Myopathy / Centronuclear Myopathy (HMLR, CNM)  
Canine Cyclic Neutropenia (Gray Collie Syndrome)  
Progressive Retinal Atrophy (cord1- PRA / crd4 PRA)  
L-2-HGA ( L- 2 - hydroxyglutaric aciduria ) L2HGA  
von Willebrand disease Type I (vWD I)  
von Willebrand disease Type III (vWD III)  
Neuronal Ceroid Lipofuscinosis ( CL / NCL )  
Trapped Neutrophil Syndrome ( TNS )  
Progressive Retinal Atrophy (crd PRA)  
PDP 1 Deficiency (Pyruvate Dehydrogenase Phosphatase 1 Deficiency)  
Factor VII Deficiency  
Progressive Retinal Atrophy (rcd1 PRA)  
Progressive Retinal Atrophy (rcd1a PRA)  
Juvenile Brain Disease ( JBD ) / Juvenile Encephalopathy ( Epilepsy )  
Microphthalmia ( RBP4 )  
French Bulldog DNA bundle  
Leonberger DNA bundle  
Spanish Water Dog DNA bundle  
Lethal Acrodematitis ( LAD )  
BRAF Mutation ( transitional cell carcinoma )  
MDR1 Gene Varian / Ivermectin Sensitivity *  
Exercise Induced Collapse ( EIC )  
Dwarfism (Pituitary Dwarfism / Hypopituitarism)  
Degenerative Myelopathy / Degenerative Radiculomyelopathy) DM (Exon 2)  
Greyhound Neuropathy (Hereditary Neuropathy)  
Brittle Bone Disease (Osteogenesis Imperfecta)  
Glycogen Storage Disease (GSDllla)  
Hereditary Cataract (HSF4)  
Neonatal encephalopathy (NE / NEWS)  
Haemophilia B (factor IX deficiency)  
JEB (Junctional Epidermolysis bullosa)  
Primary Lens Luxation (PLL)  
Brachyury (Bobtail Gene / Short Tail)  
Familial Nephropathy (FN) / Hereditary Nephropathy *  
Startle Disease (SD) / Hyperekplexia  
Familial Nephropathy (FN) / Hereditary Nephropathy  
Myostatin Mutation ("Bully" Whippet)/ Double Muscling  
Hereditary Nephritis / Samoyed Hereditary Glomerulopathy  
Episodic Falling in Cavalier King Charles Spaniel (EF)  
Dry Eye and Curly Coat syndrome (CCS)  
CKCS Pack A: Episodic Falling + Dry Eye Curly Coat syndrome  
Haemophilia A (factor VIII deficiency)  
Congenital Hypothyreosis / hypothyroidism ( CHG )  
Hereditary Nasal Parakeratosis (HNPK)  
Juvenile Epilepsy (JE)  
Musladin-Lueke syndrome (MLS)  
Ichthyosis *  
Neonatal Cortical Cerebellar Abiotrophy (NCCD)  
Dwarfism (Skeletal Dysplasia 2 / SD2 )  
Primary Open Angle Glaucoma (POAG)  
Progressive Retinal Atrophy (generalized PRA)  
Progressive Retinal Atrophy (GR-PRA1)  
Progressive retinal atrophy ( rcd4-PRA) / LOPRA  
Alaskan Malamute Polyneuropathy (AMPN / IPAM / HPAM)  
Pug Dog Encephalitis (PDE) / Necrotizing Meningoencephalitis (NME)  
Polycystic Kidney Disease (PKD)  
Pompe's Disease (Glycogen Storage Disease type II / GSDII)  
Primary ciliary dyskinesia (PCD)  
Protein Losing Nephropathy (PLN)  
Late Onset Ataxia (LOA)  
Cobalamin Malabsorption (Imerslund-Gräsbeck syndrome (IGS))  
Spinocerebellar ataxia (SCA)  
pap-PRA1 (Progressive Retinal Atrophy)  
Progressive Retinal Atrophy (BAS PRA)  
CMSD (Canine Multiple System Degeneration)  
Hereditary Cataract (HSF4) *  
Special offer 4: Juvenile Epilepsy + Furnishing + LSD  
Progressive Retinal Atrophy (prcd-PRA): (8094P / 8127)  
Thrombopathia (Thrombopathy)  
Digital Hyperkeratosis (DH) (Hereditary Footpad Hyperkeratosis / Corny Feet)  
Degenerative Myelopathy / degenerative radiculomyelopathy) DM (Exon 1)  
Degenerative Myelopathy / degenerative radiculomyelopathy) DM (Exon 1 + Exon 2)  
Ectodermal Dysplasia / Skin Fragility Syndrome (ED / SFS)  
Hypomyelination (Shaking Puppy Syndrome) SPS  
JRT and PRT Pack A: Late Onset Ataxia (LOA) + Spinocerebellar Attaxia (SCA)  
JRT and PRT Pack B:Late Onset Ataxia (LOA) + Spinocerebellar Attaxia (SCA) + PLL + JBD  
Leonberger Polyneuropathy 1 ( LPN1)  
Hereditary Ataxia (HA)  
Finnish Hound Ataxia / Cerebellar Ataxia (FHA / CAFH)  
Dandy-Walker-Like Malformation (DWLM)  
Persistent Müllerian duct syndrome (PMDS)  
Fanconi Syndrome (FS)  
Lagotto Storage Disease (LSD)  
Juvenile Laryngeal Paralysis & Polyneuropathy (JLPP)  
Progressive Retinal Atrophy (CNGA1 PRA)  
Achromatopsia (day blindness) / ACHM  
Progressive Retinal Atrophy (GR-PRA2)  
Unspecified test  
Postoperative Hemorrhage (P2Y12 / P2RY12)  
Glanzmann Thrombasthenia (Thrombasthenia, Thrombasthenic thrombopathia, GT)  
Prekallikrein Deficiency (KTK) / Fletcher Factor Deficiency  
C3 Deficiency (Complement Component 3 deficiency)  
Congenital Myasthenic Syndrome (CMS)  
Bardet Biedl Syndrome (BBS)  
GM2 Gangliosidosis Variant 0 (Sandhoff Disease)  
Macrothrombocytopenia ( MTC-D )  
Renal Cystadenocarcinoma and Nodular Dermatofibrosis (RCND)  
Vitamin D-dependent Rickets (HVDRR)  
Amelogenesis Imperfecta (AI) / Familial Enamel Hypoplasia (FEH)  
X-linked Myotubular Myopathy (XLMTM)  
Collie Eye Anomaly (CEA) / Choroidal Hypoplasia (CH) *  
Macrothrombocytopenia ( MTC- R )  
Muscular Dystrophy (MDL)  
Mucopolysaccharidosis type IIIa (MPS IIIA)  
Neuroaxonal Dystrophy ( NAD )  
Progressive Retinal Atrophy (rcd2-PRA) by Laboklin  
Ichthyosis ( Epidermolytic Hyperkeratosis (EHK) )  
May-Hegglin Anomaly (MHA)  
Alaskan Husky Encephalopathy (AHE)  
Cerebral Dysfunction (CDF)  
Dwarfism ( Chondrodysplasia / disproportinate short-limbed )  
Ichthyosis (Congenital Ichthyosis / Great Dane Ichthyosis)  
Hemorrhagic Diathesis / Bleeding Diathesis (Canine Scott Syndrom)  
Glycogen storage disease type Ia (GSD Ia) / VON Grieke Disease  
Gallbladder Mucoceles (GBM)  
Primary Hyperoxaluria type I (PH I)  
Hyperuricosuria / Urate Stones (HUU, SLC)  
Severe Combined Immunodeficiency (SCID)  
Leukocyte Adhesion Deficiency type III (LAD III)  
Cleft Lip / Palate and Syndactyly (CLPS)  
Progressive Retinal Atrophy (crd1 PRA)  
Progressive Retinal Atrophy (CRD2 PRA)  
Spondylocostal Dysostosis (Comma Defect)  
Canine Multi-Focal Retinopathy (CMR)  
Craniomandibular Osteopathy (CMO)  
Retinal Dysplasia (RD) / Oculo Skeletal Dysplasia (OSD)*  
Special Offer: DM (Exon 2) + MDR1  
Special Offer Chinese Crested: PLL + prcd PRA + rcd3 PRA + DM Exon 2  
Warbung Micro Syndrome 1 (WARBM1)  
Raine Syndrome  
van den Ende-Gupta Syndrom (VDEGS)  
Lundehund-Syndrome ( Lymphagetasia )  
Obesity / Adiposity ( ADI )  
Alexander Disease (AxD) / Leukodystrophy  
Spinal Dysraphism / Neural Tube Defects ( NTD )  
Spongy Degeneration with Cerebellar Ataxia ( SDCA1 )  
XL - PRA (Progressive retinal Atrophy)  
Nemaline Myopathy (NM)  
Beagle DNA Bundle : IGS + Factor VII + MLS + NCCD + Osteogenesis imperfecta + PK + POAG  
Poodle DNA Bundle: DM exon2 + rcd4 PRA + NE + prcd-PRA + vWD1  
Golden Retriever DNA bundle: GR-PRA1 + GR-PRA2 + Ichthyosis + prcd-PRA + Muscular Dystrophy + NCL  
Pug Special Offer: DM Exon2 + MH + PDE / NME + PK + PLL  
Aussie DNA bundle: CEA * + DM exon2 + HSF4 + MDR1 + Brachyury + NCL + prcd-PRA *  
Collie DNA Bundle: CEA + DM exon2 + IPD + MDR1 + rcd2-PRA  
Border Collie DNA Bundle: CEA + IGS + MDR1 + Raine + SN + NCL + TNS + GGD  
Pack A: CNM + DM exon2 + EIC + HNPK + OSD + prcd-PRA + SD2  
Pack B: AxD + Cystinuria + Narcolepsy + Obesity + PK + SLC + XL-MTM  
Ichthyosis  
Catalase Deficiency ( CAT ) / Hypocatalasemia / Acatalasia  
Juvenile Myoclonic Epilepsy ( JME )  
Paroxysmal Dyskinesia ( PxD )  
Spongy Degeneration with Cerebellar Ataxia ( SDCA2 )  
Belgian Shepherd Special Offer : SDCA1 + SDCA2  
Sensory Neuropathy ( SN )  
Acute Respiratory Distress Syndrome ( ARDS )  
POAG / PLL Primary Open Angle Glaucoma (POAG) and Primary Lens Luxation (PLL)  
Shar Pei auto-inflammatory disease (SPAID)  
Dystrophic Epidermolysis Bullosa (DEB)  
Doberman DNA bundle (DM2 + vWDI + Narcolepsy + B Locus + D Locus)  
Landseer DNA bundle (Cystinuria + DM2 + D-Locus (D1) + MD + Thrombopathia)  
Rhodesian Ridgeback DNA Bundle (DM2 + Haemophilia B + B Locus + JME + D Locus)  
Rottweiler DNA bundle ( DM2 , LEMP , JLPP , CL1 , XL - MTM )  
Leonberger Polyneuropathy 2 ( LPN2 )  
Hereditary Nasal Parakeratosis (HNPK)  
Subacute Necrotizing Encephalopathy (SNE)  
ISDS Exclusive Border Collie DNA Bundle: CEA 1* + IGS + SN + TNS  
Acral Mutilation Syndrome ( AMS )  
Lafora Disease (LAF / LD) / Myoclonic Epilepsy  
Shetland DNA Bundle: CEA + DM Exon 2 + vWD Type III + MDR1 + CNGA1-PRA  
CKCS Pack B: DM Exon2 + Episodic Falling + DryEye + MD + MTC  
Progressive Retinal Atrophy (rcd3 PRA)  
Old English Sheepdog (Bobtail) DNA bundle: DM Exon2 + EIC + HA + MDR1 + PCD  
German Shepherd and Wolfdog DNA Bundle  
Glaucoma and Goniodysgenesis (GGD)  
Leukoencephalomyelopathy ( LEMP )  
Hereditary Deafness ( PTPRQ )  
Type B PRA * (GeneSeek)  
Neuronal Ceroid Lipofuscinosis Combi in ACD & AUSSIE ( NCL Combi )  
Chondrodystrophy (CDDY with IVDD Risk) and Chondrodysplasia (CDPA)  
Mycobacterium Avium Complex ( MAC ) sensitivity  
Australian Cattle Dog bundle (DM Exon2 + NCL + PLL + prcd-PRA (partnerlab) + rcd4-PRA)  
Dachshund DNA bundle (IVDD-risk + Osteogenesis imperfecta + NCL + cord1-PRA + crd-PRA)  
English Springer Spaniel DNA bundle (AMS + FN + SPS + Fucosidosis + PFKD + cord1-PRA )  
Welsh Corgi DNA bundle (Brachyuria + IVDD-risk + DM exon2 + rcd3-PRA + vWD1)  
Cocker Spaniel DNA bundle (AMS + FN + prcd PRA)  
Leukoencephalopathy ( LEP )  
Larynx / Laryngeal Paralysis ( LP )  
Dilated Cardiomyopathy ( DCM )  
Mucopolysaccharidosis type IIIb ( MPS3b )  
Renal dysplasia and hepatic fibrosis ( RDHN )  
Stargardt disease ( STGD )  
NECAP-1 Progressive Retinal Atrophy ( NECAP1 PRA / NECAP PRA5)  
SCWT DNA bundle (DM + PLN + PxD + RBP4 + SLC )  
Inflammatory Pulmonary Disease ( IPD )  
Retinal dysplasia ( RD ) / Oculoskeletal Dysplasia ( OSD 3 )  
Shiba Inu DNA bundle (GM1 , GM2 , A Locus and E Locus)  
Copper storage disease - Copper toxicosis (CT) *  
Hypophosphatasia ( HPP )  
Upper Airway Syndrome ( UAS )  
Portuguese Waterdog DNA Bundle ( GM1 + prcd PRA + Improper Coat)  
Bull Terrier DNA bundle ( LAD + PLL + LP + PKD )  
Australian Shepherd KC DNA bundle (MDR1+ prcd-PRA + CEA + HSF4)  
Beagle KC DNA bundle (F7 + IGS BG + MLS + NCCD)  
Border Collie KC DNA bundle (GG +IGS BC+NCL BC+TNS+SN+MDR1+CEA)  
Chinese Crested KC DNA bundle (PLL + prcd-PRA)  
Collie (Rough) KC DNA bundle (DM Exon2 + rcd2-PRA + MDR1 + CEA)  
English Springer Spaniel (ESS) KC DNA bundle (AMS+cord1-PRA+Fucosidosis+PFKD)  
French Bulldog KC DNA bundle (DM Exon2+SLC+HSF4)  
German Shepherd KC DNA bundle (DM Exon2+F8+MDR1)  
Golden Retriever KC DNA bundle (GR1-PRA+GR2-PRA+Ichthyosis)  
Labrador Retriever KC DNA bundle (EIC+HNPK+SD2+CNM+prcd-PRA)  
Staffordshire Bull Terrier KC DNA bundle  
Cardiomyopathy with Juvenile Mortality (CJM)  
Charcot -Marie - Tooth (CMT )  
Leukodystrophy ( LD )  
Dermatomysitis ( DMS )  
Progressive Retinal Atrophy Type B1 PRA (HIVEP3)  
Behavior Propensity BP  
Oculocutaneous Albinism Type 4 (OCA4)  
Inflamatory Myopathy (Myositis) IM  
Lethal Lung Disease (LLD)  
Cystinuria (Dominant)  
SCWT GB-Club bundle (DM Exon2 + PLN + RBP4)  

 
 
Home   |   Genetic Diseases  |   Coat Colours / Length  |   Identity / Parentage  |   Reptiles & Amphibians  |   Avian Tests  |   Profiles / Screening  |   Infectious Diseases  |   Organs / Parameters  |   About us  |   Contact Us
LABOKLIN GmbH & Co. KG
ISO / DIN 17025 Accredited Laboratory
© 2007 Laboklin (UK)
125 Northenden Road, Manchester, M33 3HF
Tel. 0161 282 3066