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Breeds
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Bull Mastiff
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English Mastiff
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The Disease |
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Progressive retinal atrophy (PRA) is a leading hereditary cause of blindness in pedigree dogs as is its counterpart retinitis pigmentosa (RP) in humans. PRA shows genetic heterogeneity, as does RP, with several distinct forms already recognized and several more remaining to be investigated.
Pups show signs of night-blindness by 6 weeks of age. By the age of 1-2 years most affected dogs are completely blind.
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Trait of Inheritance |
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Mastiffs and Bullmastiffs exhibit the first, and so far, only form of canine Progressive Retinal Atrophy - PRA - that is inherited as a dominant trait. Therefore only affected or unaffected dogs can be found. The Mastiffs are affected by the late onset form of the PRA.
Since vision loss might be recognised first when the dog is several years old, it is important to determine the actual status of the dog before breeding it.
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Inheritance : AUTOSOMAL
DOMINANT
trait
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Sire |
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Dam |
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Offspring |
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Clear
(N/N)
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x |
Clear
(N/N)
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> |
100% Clear
(N/N)
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clear
(N/N)
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x |
affected
(N/PRA)
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> |
50% Clear
(N/N) + 50%
affected (N/PRA)
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clear
(N/N)
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x |
affected
(PRA/PRA)
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> |
100% affected
(N/PRA)
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affected
(N/PRA)
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x |
Clear
(N/N)
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> |
50% Clear
(N/N) + 50%
affected (N/PRA)
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affected
(N/PRA)
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x |
affected
(N/PRA)
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> |
25% clear
(N/N) + 25% affected
(PRA/PRA)
+ 50% affected (N/PRA)
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affected
(N/PRA)
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x |
affected
(PRA/PRA)
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> |
50% affected
(N/PRA)+ 50%
affected (PRA/PRA)
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affected
(PRA/PRA)
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x |
Clear
(N/N)
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> |
100% affected
(N/PRA)
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affected
PRA/PRA
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x |
affected
(N/PRA)
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> |
50% affected
(N/PRA)+ 50%
affected (PRA/PRA)
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affected
(PRA/PRA)
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x |
affected
(PRA/PRA)
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> |
100% affected
(PRA/PRA)
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Clear
Genotype: N / N [ Homozygous normal ]
The dog is noncarrier of the mutant gene.
The dog will never develop Progressive Retinal Atrophy (Dominant PRA) and therefore it can be used in breeding.
Affected
Affected dogs can have one of two genotypes:
Genotype: N / PRA [ Heterozygous affected], or
Genotype: PRA / PRA [ Homozygous mutant ]
It is not recommended to use affected dogs in breeding
The dog will develop Progressive Retinal Atrophy (Dominant PRA) and will pass the mutant gene to its offspring
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Description |
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This is a mutation-based gene test, which offers many advantages over other methods
Progress in molecular genetics has allowed the identification of the gene mutation responsible for PRA in the Bull and English Mastiff.
By DNA testing, the responsible mutation can be shown directly. This method provides a very high accuracy test and can be done at any age. It offers the possibility to distinguish between affected and clear dogs. This is an essential information for controlling the disease in the breed.
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Sample Requirements |
Whole blood in EDTA tube (0.5 - 1 ml) or Buccal swabs. . |
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Price
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£ 48.00 (including VAT)
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| To order:
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Download
Order Form from this link 
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Complete the order form and send it together
with your samples to the following address:
Laboklin (UK), 125 Northenden Road, Manchester, M33 3HF
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