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**NEW**



Bengal Special offer:
3 Bengal Specific DNA tests for just £60.00 incl VAT
Bengal DNA bundle (rdAc-PRA + b-PRA + PK-Def) 



British Special offer:
3 Breed Specific DNA tests for just £60.00 incl VAT
British Short / Long Hair DNA bundle (PKD + pd-PRA + ALS)



Burmese Special offer:
3 Breed Specific DNA tests for just £66.00 incl VAT
Burmese DNA bundle (Hypokalemia (BHK) + Head Defect + Gangliosidosis (GM2)



Birman Special offer:
4 Breed Specific DNA tests for just £66.00 incl VAT
Birma DNA bundle (PKD + pd-PRA + Hypotrichiose + MPS6)



Maine Coon Special offer:
3 Breed Specific DNA tests for just £60.00 incl VAT
Maine Coon DNA bundle (HCM1 + SMA + PK-Def)



Ragdoll Special offer:
4 Breed Specific DNA tests for just £60.00 incl VAT
Ragdoll DNA bundle (HCM1 + HCM3 + PKD + pd-PRA)



Norwegian Special offer:
3 Breed Specific DNA tests for just £60.00 incl VAT
Norwegian Forest DNA bundle (PK-Def + Amber + GSD4)



Feline Special Offer:
8 cat DNA tests for just £79.95 including VAT
HCM, HCR, GSD4, PKD, PRA, PK-Def., SMA, Blood Groups
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February 2022    

LABOKLIN NEWS

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LABOKLIN AT CRUFTS 2022

  10th - 13th March

Laboklin at Crufts 2022

Dear Breeder

We are pleased to announce that will be at Crufts from 10th to 13th March 2022 and we look forward to seeing you there.

Our stand is located in Hall 3 opposite the restaurant, it is stand number   3-7a  as shown in the diagram.

We are always talk to you on the phone, by email or even via facebook, however, at Crufts we are very excited to meet you in person and to answer any questions you have, please stop by and say hi.

Crufts offer

mapp to Laboklin stand at Crufts

discount on all DNA tests submitted at

and this offer includes our Breed Specific DNA Bundles and the brand new KC breed bundles How to submit a sample at Crufts:

How to submit a sample at :

  1. Bring your dog to our stand 3-7a: we will take a DNA sample for your genetic test, all you need to do is complete the order form and pay the fees. Or,
  2. If you don't want to wait in the queue, you can prepare your sample in advance and bring it together with the attached order form with you to our stand. You can order a free DNA testing kit on our website, click on the following link to order:

    Request sample materials

    We will send you a testing kit which also contains order form and instructions on how to take DNA sample from the mouth. Prepare your sample up to a week before your planned visit, just hand the sample to us at the show.
  3. If you prefer to use  blood for your test, ask your vet to collect 0.5-1 ml of whole blood in EDTA blood tube, bring it together with the completed order form to the show, just hand it to us. (you can order free EDTA blood tube from our website http://www.laboklin.co.uk )

Please note we will only accept Cash, Cheques or Postal Orders at the show. If you wish to pay by card, you can complete the card payment section on the order form. Paypal payments must be made in advance.

Turnaround: 1-3 weeks for the majority of tests from Monday 14th March.

 The attached order form will only be accepted at Crufts 2022.

If you have any questions, please email info@laboklin.co.uk or ring 0161 2823066.

We look forward to seeing you at .

Kind regards

The Laboklin Team

LABOKLIN (UK)
Laboratory For Veterinary Diagnostics
125 Northenden Road
Manchester
M33 3HF
 
Tel: 0161 282 3066
Fax: 0161 973 3434
www.laboklin.co.uk
www.facebook.com/Laboklin



Laboklin Newsletter February 2022

Feb 2022
Newsletter  PDF
Download
Crufts 2022 Order Form

Crufts 2022
 Order Form PDF
Download



Progressive Retinal Atrophy (JPH2 - PRA )

in Shih Tzu 

 

Progressive retinal atrophy (PRA), common autosomal recessive disorder affecting several dog breeds including Shih Tzu, is characterized by degeneration of photoreceptors leading to blindness. A mutation in the JPH2 gene has been identified to be responsible for PRA in the Shih Tzu breed and the test is now available at Laboklin.

cost £48.00

more informatrion is available on the following link:


new

Exfoliative Cutaneous Lupus Rrythematosus

( ECLE ) / Lupoid Dermatosis

in German Shorthair Pointer , Hungarian Vizsla , Hungarian Wirehaired Vizsla (Vizslak) .

German Shorthair Pointer

Exfoliative Cutaneous Lupus Erythematosus (ECLE), which is also known as Lupoid Dermatosis is an inherited monogenic (controlled by one gene) disease that has been observed in the German Shorthaired Pointer and Hungarian Vizsla breeds. Symptoms start in the first year of age and include skin lesions, lameness, scaling, erythema (reddening of the skin), erosions/ulcers, scarring, disfiguration, decreased quality of life, progresses to joint pain, oligospermia (low sperm count) in males which progressed to azoospermia (absence of sperm), irregular heat cycles in females. Dogs with this disease have dramatically shortened life expectancies and are generally humanely euthanized upon diagnosis. The mode of inheritance is autosomal recessive, which means that the disease occur when the puppy inherits two copies of the mutation, one from each parent.

cost £48.00

more informatrion is available on the following link:


new

Dilated Cardiac Myopathy (DCM)

in Doberman, Schnauzer and Welsh Springer Spaniel

DCM inherited heart diseaseD

The disease is characterized by a swelling of one or both of the heart?s ventricles (lower chambers) which weakens the ability of the heart to pump blood and consequently the heart becomes larger and the beats become weaker. Symptoms can vary in the different breeds. Some affected dogs may not exhibit any visible signs and yet die suddenly without warning, or may not show any symptoms for years, however, eventually, start exhibiting symptoms of ill health including: lethargy, loss of appetite, coughing especially during exercise, gasping for breath, fainting or collapsing and progressive abdominal swelling. Although these signs can signify the onset of heart failure, they are also shared with other conditions and therefore testing is vital for the diagnosis. In Schauzer the disease is caused by a mutation in the RBM20gene, In Welsh Springer Spaniel it is caused by a mutation in the PLN-gene, whereas is Doberman it can be caused by a mutation in the PDK4 gene, and / or mutation in the TTN gene.

cost £48.00 each

more informatrion is available on the following links:


new

CNS Atrophy with Cerebellar Ataxia (CACA)

in Belgian Shepherd Dog (Malinois)

Belgian Shepherd Dog

 

Our cooperation partner Prof. Tosso Leeb and his team from the University of Bern have identified a new genetic variant causing a neurological disease called CNS atrophy and cerebellar ataxia (CACA) in the breed Belgian Shepherd. Affected puppies show uncoordinated movements, intention tremor, short episodes of spastic fits, general elevated muscle tone and a reduced swallowing reflex. Moreover, affected puppies show less body weight increase as their unaffected littermates. First signs could be observed at the age of about 2 weeks. However, the severity of the signs are highly variable. Many affected puppies have to be euthanized a few weeks after the first signs whereas an affected dog with less intense symptoms has been reported to become up to 10 years old.

cost £48.00 each

more informatrion is available on the following link:


new

Macular Corneal Dystrophy ( MCD / CHST6 )

in Labrador Retriever

Macular Corneal Dystrophy ( MCD / CHST6 )

Macular Corneal Dystrophy (MCD) is an inherited eye disease affecting humans and dogs. The disease characterized by progressive diffuse cloudiness of the cornea and the presence of grayish-white spots in the superficial corneal stroma. The disease is caused by a mutation in the CHST6 gene which causes abnormal accumulation of complex carbohydrates called glycosaminoglycans in the cornea, mainly in the keratocytes and the corneal epithelium.

Clinical symptoms are usually seen in affected middle aged dogs, and include: Visual impairment, corneal cloudiness, grey-white spots of various sizes on the cornea, blood vessels maybe seen across the corneal surface, increased intensity of the corneal cloudiness and loss of visual acuity.

This mutation has only been reported in Labrador Retrievers, but may be found in Labrador-cross breeds.

Treatment: in dogs there is no treatment. In human, this is treated by corneal transplant.

cost £48.00 each

more informatrion is available on the following link:


new

Ichthyosis Type 2

in Golden Retriever

Ichthyosis Type 2 in Golden Retriever

Ichthyosis type 2 is another variant which causes Ichthyosis in Golden Retriever, this test helps in explaining cases which was tested negative for the already known Ichrthyosis variant. Ichthyosis is a genetic disease causing dysfunction of the keratin in the skin, which leads to the production of large, differently pigmented skin scales. Due to the fish-like look of this scales the name was formed from the Greek word for fish: "Ichthŭs". Additionally, the pigmentation of the skin can be altered.

Dogs which are affected by this dermatosis develop first symptoms soon after birth. Unfortunately, there is no treatment for this disease. In some cases, formation of scales decreases in old dogs.

 

cost £48.00 each

more informatrion is available on the following link:


Progressive Retinal Atrophy (PRA)

more variants identified and more breeds affected

PRA Stargardt Disease more breeds

The following Progressive retinal atrophy (PRA) tests have recently been added:


Pituitary Dwarfism

has been identified in Tibetan Terrier

the test is now valid for the following breeds: Czechoslovakian Wolfdog, German Shepherd, Karelian Bear Dog, Lapland Reindeer Dog, Lapponian Herder, Saarloos Wolfdog, Tibetan Terrier, White Swiss Shepherd

Pituitary Dwarfism in Tibetan Terrier

Inherited Dwarfism is a condition in which the production of the Growth Hormone (GH) is inadequate. Growth hormone is secreted by the pituitary gland and has many effects on the body including control of growth rate, maintenance of hair coat, and bone and teeth development. Affected dogs appear normal at birth, but show evidence of failure to grow by two to three months of age. Symptoms include small stature compared to littermates, retention of puppy coat, hair loss, darkening of the skin, delayed eruption or absence of permanent teeth, a shrill bark, Small testicles and sometimes infertility in the male, Absence of heat and sometimes infertility in the female.

Affected dogs appear normal at birth, but show evidence of failure to grow by two to three months of age. Symptoms include small stature compared to littermates, retention of puppy coat, hair loss, darkening of the skin, delayed eruption or absence of permanent teeth, a shrill bark, Small testicles and sometimes infertility in the male, Absence of heat and sometimes infertility in the female.

cost £48.00 each

more informatrion is available on the following link:


new

Chihuahua DNA bundle

the most relevant tests for the breed in one submission

Chihuahua DNA bundle CDDY/CDPA (IVDD risk) + MTC + NCL + prcd-PRA)

  1. Chondrodystrophy (CDDY with IVDD Risk) and Chondrodysplasia (CDPA)
  2. Macrothrombocytopenia ( MTC-D )
  3. Neuronal Ceroid Lipofuscinosis ( CL / NCL )
  4. Progressive Retinal Atrophy (prcd-PRA): (8094P / 8127)

cost £138.00 each

more informatrion is available on the following link:


new

Giant Schnauzer DNA bundle

the most relevant tests for the breed in one submission

 

Giant Schnauzer DNA bundle

  1. Degenerative Myelopathy / Degenerative Radiculomyelopathy) DM (Exon 2)
  2. Dilated Cardiomyopathy ( DCM )
  3. Hyperuricosuria / Urate Stones (HUU, SLC)
  4. NECAP-1 Progressive Retinal Atrophy ( NECAP1 PRA / NECAP PRA5)
    KC* DNA scheme in Giant Schnauzer
  5. Progressive Retinal Atrophy (prcd-PRA): (8094P / 8127)
    KC* DNA scheme in Giant Schnauzer

cost £156.00

more informatrion is available on the following link:


new

Russian Black Terrier DNA bundle

the most relevant tests for the breed in one submission

 

Russian Black Terrier DNA bundle
  1. Degenerative Myelopathy / Degenerative Radiculomyelopathy) DM (Exon 2)
  2. Hyperuricosuria / Urate Stones (HUU, SLC)
    KC* DNA scheme in Russian Black Terrier (RBT)
  3. Juvenile Laryngeal Paralysis & Polyneuropathy (JLPP)
    KC* DNA scheme in Russian Black Terrier (RBT)

cost £138.00

more informatrion is available on the following link:


new

Yorkshire Terrier DNA bundle

the most relevant tests for the breed in one submission

 

Yorkshire Terrier Dna Bundle
  1. Chondrodystrophy (CDDY with IVDD Risk)and Chondrodysplasia (CDPA)
  2. L-2-HGA ( L- 2 - hydroxyglutaric aciduria ) L2HGA
  3. Primary Lens Luxation (PLL)
  4. Progressive Retinal Atrophy (prcd-PRA): (8094P / 8127)
  5. Subacute Necrotizing Encephalopathy (SNE)

cost £156.00

more informatrion is available on the following link:


new

Bulldog DNA bundle

the most relevant tests for the breed in one submission

Bulldog DNA bundle
  1. Degenerative Myelopathy / Degenerative Radiculomyelopathy) DM (Exon 2)
  2. Hyperuricosuria / Urate Stones (HUU, SLC)
    KC* DNA scheme in Bulldog (English)
  3. Cystinuria type III
  4. Canine Multi-Focal Retinopathy (CMR)

cost £138.00

more informatrion is available on the following link:


new

Tibetan Terrier DNA bundle

Tibetan Terrier DNA bundle
  1. Neuronal Ceroid Lipofuscinosis ( CL / NCL )
    KC* DNA scheme in Tibetan Terrier
  2. Primary Lens Luxation (PLL)
    KC* DNA scheme in Tibetan Terrier
  3. Progressive retinal atrophy ( rcd4-PRA) / LOPRA
    KC* DNA scheme in Tibetan Terrier
  4. Degenerative Myelopathy / Degenerative Radiculomyelopathy) DM (Exon 2)
  5. Dwarfism (Pituitary Dwarfism / Hypopituitarism)
    KC* DNA scheme in Tibetan Terrier

cost £156.00

more informatrion is available on the following link:


new

Irish Red & White Setter DNA bundle

IrishRed and White Setter DNA tests
  1. CLAD (Canine Leukocyte Adhesion Deficiency)
  2. Globoid Cell Leukodystrophy (Krabbe Disease)
  3. von Willebrand disease Type I (vWD I)
    KC* DNA scheme in Irish Red and White Setter
  4. Progressive Retinal Atrophy (rcd1 PRA)
  5. Progressive retinal atrophy ( rcd4-PRA) / LOPRA

cost £138.00

more informatrion is available on the following link:


new

Labradoodle DNA bundle

Labradoodle DNA bundle
  1. Degenerative Myelopathy / Degenerative Radiculomyelopathy) DM (Exon 2)
  2. Exercise Induced Collapse ( EIC )
  3. Hereditary Nasal Parakeratosis (HNPK)
  4. Dwarfism (Skeletal Dysplasia 2 / SD2 )
  5. Neonatal encephalopathy (NE / NEWS)
  6. von Willebrand disease Type I (vWD I)
  7. Hereditary Myopathy / Centronuclear Myopathy (HMLR, CNM)
  8. Progressive Retinal Atrophy (prcd-PRA): (8094P / 8127)
  9. Progressive retinal atrophy ( rcd4-PRA) / LOPRA

cost £240.00

more informatrion is available on the following link:


new DNA testing schemes

The following tests are now part of the Kennel Club DNA testing schemes:

  • Stargardts disease (STGD) in Labrador Retriever more ..
  • Macular Corneal Dystrophy (MCD) in Labrador Retriever more ..
  • X-linked PRA Type 1 (XL-PRA1) in Samoyed more ..
  • Hereditary Nephritis / X-linked (XLHN) in Samoyed more ..
  • Copper Toxicosis (COMMD1) in Bedlington Terrier more ..
  • Pituitary Dwarfism in Tibetan Terrier more ..
  • Leukoencephalomyelopath (LEMP) in Rottweiler more ..
  • Raine?s syndrome/ Dental hypomineralisation in Border Collie more ..
  • Amelogenesis Imperfecta / Familial Enamel Hypoplasia (AI/FEH) in Japanese Akita Inu more ..
  • PRA (prcd-PRA) in American Cocker Spaniel and Barbet more ..
  • CNGA1 - PRA in Shetland Sheepdog more ..
  • vWD type 1 in Papillon (Continental Toy Spaniel) more ..
  • Primary Open Angle Glaucoma (POAG) in Norwegian Elkhound more ..
  • Dwarfism (Chondrodysplasia / disproportinate short-limbed) in Norwegian Elkhound. more ..
  • NECAP1 PRA / NECAP PRA5 in Giant Schnauzer more ..

testing is easy

To test a dog, we need a DNA sample, which can be collected using simple mouth swabs or a blood sample collected by the vet. Both buccal swabs and blood tubes are available from us free of charge. Samples can be sent to our Manchester address below.

Turnaround 2-3 weeks or sooner for most DNA test.

Request Sample Materials

LABOKLIN is a DIN EN ISO / IEC 17025 Accredited laboratory. This means that all our tests are performed according to the reliable accreditation standards and verified procedures.


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LABOKLIN (UK), 125 Northenden Road, Manchester, Greater Manchester, M33 3HF, United Kingdom

 
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LABOKLIN GmbH & Co. KG
ISO / DIN 17025 Accredited Laboratory
© 2007 Laboklin (UK)
125 Northenden Road, Manchester, M33 3HF
Tel. 0161 282 3066