Progressive Retinal Atrophy (Shet PRA) in Shetland Sheepdog (Sheltie)
Progressive retinal atrophy (PRA) refers to a group of genetic disease that occur in a number of dog breeds.
The disease is characterised by vision impairment caused by degeneration of the retina in both eyes leading to blindness. The mutation responsible for this disease has already been identified in a number of breeds and DNA tests have been developed to enable breeders to avoid breeding affected dogs.
PRA in shelties is clinically similar to PRA in other breeds but the mutation leading to the disease in shelties was not identified. In a recent study scientists found that in shelties there is more than one PRA variant. Scientists have been able to identify one of the mutations that causes PRA in this breed and a DNA test is now available from Laboklin.
In Shelties, the disease shows a varying age on onset. In a study on affected shelties, PRA was diagnosed between the age of 2 and 11.
Exercise Induced Collapse ( EIC ) has now been validated in Clumber Spaniel
We are pleased to announce the Exercise Induced Collapse DNA test has now been validated in Clumber Spaniel. We would like to thank the Clumber Spaniel Club and the Working Clumber Spaniel Society, and all Clumber Spaniel owners who submitted samples that helped in our research to validate the test in this breed.
Exercise Induced Collapse (EIC) is
an inherited condition that affects
a number of dog breeds including
Chesapeake Bay Retriever, German
Wirehaired Pointer, Labrador
Retriever, Old English Sheepdog
(Bobtail), Pembroke Welsh Corgi,
Cocker Spaniel, Curly Coated
Retriever, Boykin Spaniel and Bouvier des Flanders. EIC has now been validated in Clumber Spaniel. Affected dogs can endure mild to moderate exercise but after 5 to 20 minutes of heavy exercise with extreme excitement, the dog shows weakness and then collapse. Severely affected dogs may collapse whenever they are exercised to this extend � other dogs only exhibit collapse episodes sporadically. Signs of EIC are not typically seen until the dog begin intense training. First symptoms are usually noted between 5 months and 3 years of age. However, it is confirmed that some affected dogs did not have collapse episodes until as late as age 10.
Laboklin prices have not changed for
the past five years, during this
time, in order to cope with the ever
increasing demand for our DNA
testing services, we have been
investing heavily in cutting edge
technologies, state of the art
equipment, new robotic systems and
automated sample handing equipment,
all operated by our highly qualified
scientists. These developments did
not only increase efficiency to
highest attainable standards but
also has now enabled us to pass on
additional savings to you.
For an ISO 17025 Accredited
laboratory, our prices are now
New pricing System is effective from
1st September 2015. Until then all
samples received are charged at
LABOKLIN will be at
The UK National Dwarf German Shepherd Rally
Sunday 7th June 2015
The Elephant, Shavington, Crewe, Cheshire CW2 5DZ
We are pleased to announce that LABOKLIN
will be at the UK National Dwarf German
Shepherd Rally, The aim of the UK National Dwarf German Shepherd Rally is to raise awareness about Pituitary Dwarfism, an inherited condition suffered by German Shephered.
Adult Onset Neuropathy* (AON) in English Cocker Spaniel and Field Spaniel
Adult Onset Neuropathy (AON) is an inherited neurological disorder in the English Cocker Spaniel breed. Symptoms typically begins between the age of 7.5 and 9 years. The Disease is characterised by progressive weakness that starts with the hind limbs leading to wobbly gait, wide-base stance and angled hocks. The disease...
Dandy-Walker-Like Malformation (DWLM)in Purebred Eurasier Dogs with Familial Non-Progressive Ataxia
DWLM is a genetic disorder found in Eurasier dogs characterised by non-progressive ataxia, symptoms have been noted in dogs at 5 � 6 weeks old. The severity of the ataxia varies between dogs, from mild truncal sway, mild lack of movement coordination, subtle dysmetric gait, imbalance and pelvic limb ataxia to severe cerebellar ataxia in puppies and episodic falling or rolling. Follow-up examinations in adult dogs showed improvement of the cerebellar ataxia and a still absent menace response. Epileptic seizures occurred in some dogs...
Persistent M�llerian duct syndrome (PMDS) in Miniature Schnauzer
Muellerian ducts (paramesonephric ducts) are small structures that exist in both male and female embryos during the early fetal development, at 35-36 days of gestation, the embryo begins to differentiate into male or female. In the female, Muellerian ducts will develop to form the uterine tubes, uterus, cervix, and the upper one-third of the vagina. In the male, Muellerian ducts are lost because the testes starts producing a hormone that causes regression of the Mullerian ducts.
In Miniature Schnauzer males which are affected by Persistent M�llerian duct syndrome (PMDS), the M�llerian ducts fail to regress during sexual differentiation, and therefore, all M�llerian duct derivatives, bilateral oviducts, a complete uterus with cervix and the cranial portion of the vagina, are also present...
The Kennel Club has just approved a new DNA testing scheme for Factor VII
Deficiency in Beagle with Laboklin.
Factor VII deficiency is a mild bleeding disorder caused by lack of factor VII (proconvertin) which plays a role in the blood clotting system. Affected dogs bruise easily and nosebleeds maybe seen. There is often prolonged bleeding after surgery or trauma and, in the cases of major surgical procedures or trauma, bleeding maybe severe...
The mutation is also found in Airedale Terrier , Alaskan Klee Kai , Giant Schnauzer , Scottish Deerhound
Cobalamin Malabsorption (Imerslund-Gr�sbeck syndrome (IGS)) in Beagle
The Kennel Club has just approved a new DNA testing scheme for Cobalamin Malabsorption (Imerslund-Gr�sbeck syndrome (IGS)) in Beagle with Laboklin.
Cobalamin malabsorption (merslunf-Gr�sbeck Syndrome (IGS)) refers to a genetic disorder by which the vitamin B12, also known as cobalamin, fails to be absorbed from the intestine. Lack of cobalamin leads to changes in the hematopoietic system and to neurological symptoms due to irreversible damage of the brain and nervous system. Symptoms include anorexia, lethargy and
Cone Degeneration (CD) by OptiGen* in Australian Shepherd, German Pointers and Alaskan Malamute
Although the disease is rare in general, within an affected line it is important to control the gene frequency so as to prevent producing puppies affected with the disease. The mutations causing CD in these two breeds occur in the same gene (CNGB3) but are distinct mutations and arose separately.
CD disease causes day blindness due to degeneration of the retinal �cones� � cone-shaped cells in the retina that respond primarily to bright daylight. CD can be diagnosed in the early weeks of the affected dog�s life. Between 8 and 12 weeks of age, when retinal development is normally completed in dogs, signs..
The Harlequin coat colour pattern is a white coat colour with irregular patches of black or other dark colour.
The Harlequin gene does not cause the Harlequin pattern without the merle gene.
A Harlequin Great Dane must have both the Harlequin gene and the Merle gene.
Harlequin is a merle modifier, it turns the areas between the dark patches into white, this is why Harlequin is only visible on dogs with the merle gene.
Harlequin will not affect the coat colour of dogs that don't have the merle gene. Dogs without the merle gene can have the Harlequin gene but without expressing it...
The Lagotto Romagnolo storage disorder is a genetic disroder characterized by movement in-coordination, which is seen as a staggering, uncoordinated gait. Other symptoms such as involuntary eye movements (nystagmus) and behavioral changes, such as aggression, have also been seen in affected dogs. The onset of the disease varies from 4 months to 4 years. The condition is progressive and symptoms in affected worsens to a degree where they need to be euthanized...
Juvenile Laryngeal Paralysis & Polyneuropathy (JLPP)* in Black Russian Terrier and Rottweiler
Juvenile Laryngeal Paralysis & Polyneuropathy (JLPP) * is a genetic disease that affects the nerves. In affected dogs, JLPP
starts with the longest nerves in the
body, one of the longest nerves is the
one that supplies the muscles of the
voice box (larynx) leading to muscle
weakness and laryngeal paralysis as the
first symptom. The vocal folds vibrate
noisily and can obstruct the flow of air
into the lungs when the dog is exercised
or when it is hot. The dog may also
choke on their food or water or
regurgitate, and this can cause
Fanconi Syndrome is a genetic disease of the kidney.
In affected dogs, the Kidney's proximal tubules fail to reabsorb vitamins, minerals, sugars and other nutrients back into the body, instead they are dumped into the urine. The loss of these nutrients results in dehydration and electrolyte imbalances along with other problem.
Fanconi Syndrome is considered as one of the most common inherited disease in Basenji .
Symptoms include polydipsia (excessive drinking), polyuria (excessive urination), and glucose in the urine (glucosuria). Untreated Fanconi Syndrome will lead to muscle wasting, acidosis and poor condition, and eventually death...
Hereditary Ataxia (HA) in Old English Sheepdog (Bobtail) and Gordon Setter .
Hereditary Ataxia (HA) is a neurodegenerative disease that affect the cerebellum causing progressive gait disturbance in both humans and dogs.
Old English Sheepdogs and Gordon Setters suffer from a juvenile onset, autosomal recessive form of canine hereditary ataxia primarily affecting the Purkinje neuron of the cerebellar cortex. The clinical and histological characteristics are similar to hereditary ataxias in humans....
This disease is caused by a mutation in the SEL1L gene. Affected dogs will show first indications of cerebellar neurodegeneration at the age of 4-12 weeks. First clinical signs are loss of balance, minor incoordination of gait and intention tremor while later symptoms can be a progressive incoordination or a complete loss of mobility.
The type 1 neuropathy (LPN1) in Leonberger starts at the age of 2-4 year and shows a severe progression. The symptoms of this polyneuropathy include wobbly gait and paralysis especially from the backhand. Affected dogs are not able to stand up in the final stage of the disease. Breathing noises, strange barking voice and difficulties in swallowing are other typical symptoms. The causative mutation causes around 20% of all polyneuropathy cases in the Leonberger breed. Other aetiologic mutations exist.
We are pleased to announce that,
after we stopped offering this test
for the past few weeks, it is now
back on the list and CHEAPER than
before, it is now �55.00.
is part of the Kennel Club DNA
Official testing Scheme in Golden Retriever.
Ichthyosis is a genetic disease causing dysfunction of the keratin in the skin, which leads to the production of large, differently pigmented skin scales. Due to the fish-like look of this scales the name was formed from the Greek word for fish: �Ichth�s�. Additionally, the pigmentation of the skin can be altered...
Digital Hyperkeratosis (DH) (Hereditary Footpad
Hyperkeratosis / Corny Feet)
The Kennel Club has just approved a new DNA testing scheme for Digital Hyperkeratosis (DH) (Hereditary Footpad Hyperkeratosis (HFH) / Corny Feet)
in Irish Terrier with Laboklin.
This disease is also called �Corny Feet� as the main symptom is thickening and hardening of the footpads. Affected dogs suffer from painful cracks and crevices sometimes leading to secondary infections. Additionally, nail growth is accelerated so that nails become deformed and crumbly. As footpads and nails are cared for, the dog's lifespan and quality of life are normal...
LABOKLIN acquires exclusive Degenerative Myelopathy European License
We are pleased to announce that LABOKLIN acquired the exclusive European license to
perform the Degenerative Myelopathy Exon 2 DNA test.
DM is a slowly progressive disease of the spinal cord. It is typically seen in older dogs after
the age of 7. The disease begins with difficulty in getting up, difficulty in walking and loss
of coordination in the hind limbs. It usually starts with weakness in one leg and the dog
maybe seen dragging its hind paws, the disease progresses to the other leg, the dog
wobbles when walking and can knuckle over. The disease continues to progress leading to
DM is a devastating incurable genetic disease that has been seen frequently in a number of
dog breeds in particular German Shepherd Dogs, Corgis, Boxers, Chesapeake Bay Retrievers,
Rhodesian Ridgebacks, and Standard Poodles. It has also been diagnosed in American Eskimo,
Golden Retriever , Labrador Retriever , Nova Scotia Duck Tolling Retriever , Shetland
Sheepdog (Sheltie) , Bernese Mountain Dog , Kerry Blue Terrier , Wire Fox Terrier , Pug ,
Borzoi (Russian Wolfhound) , Hovawart , Soft Coated Wheaten Terrier , Canaan Dog ,
Great Pyrenees, and other breeds. A key feature of DM is that it is not a painful disease.
DM is caused by a DNA mutation in exon 2 of a gene called superoxide dismutase 1 (SOD1).
It is referred to as DM EXON 2. This risk factor of having this gene was identified in 2009.
Recently another DM mutation was identified in Bernese Mountain Dogs in exon 1 of the SOD1
gene it is referred to as DM EXON 1.
Testing for DM EXON 2 is available for all dog breeds (including Bernese Mountain Dog).
Testing for DM EXON 1 is only available for Bernese Mountain Dogs, we also offer
DM EXON 1 + DM EXON 2 bundle in Bernese Mountain Dogs.
Laboklin is the only lab licensed to perform the DM EXON 2 test in Europe and samples should
only be sent to our lab.
LABOKLIN is a DIN EN ISO / IEC 17025 Accredited laboratory
When selecting a lab for your genetic testing, you need to be sure that you will be supplied
with accurate and reliable results. The technical competence of a lab depends on a number of
factors which are assessed against internationally recognised standards to demonstrate the
laboratory�s competence, impartiality and performance capability. it is like a qualification
LABOKLIN is a DIN EN ISO / IEC 17025 Accredited laboratory. Accreditation is provided by
the German National Accreditation Body DAKKS, (in the UK by UKAS). This means that all
our tests are performed according to reliable standards and verified procedures. Our
laboratory is not only subject to strict daily internal controls but also to regular external
controls ensuring our adherence to the strictest standards
LABOKLIN is not just about providing a test result, our genetic testing department is supported
and backed by in-house specialised departments including Molecular Biology, Haematology,
Serology, Pathology, Allergy, Histology, Endocrinology, Microbiology, Bacteriology and many
more areas in the diagnostic spectrum since 1989.
OFFICIAL DNA TESTING SCHEME
Imerslund-Gr�sbeck syndrome (IGS)(Cobalamin Malabsorption) in Border Collie
Cobalamin malabsorption (merslunf-Gr�sbeck Syndrome (IGS)) refers to a genetic disorder by which the vitamin B12, also known as cobalamin, fails to be absorbed from the intestine. Lack of cobalamin leads to changes in the hematopoietic system and to neurological symptoms due to irreversible damage of the brain and nervous system. Symptoms include anorexia, lethargy and failute to gain weight. Cobalamin malabsorption can be managed by supplementation with regular doses of cobalamin..
MDR1 is a genetic disorder found in many dog breeds. Affected dogs, when treated with certain common drugs such as Ivermectin and loperamide (Imodium), are unable to pump out these drugs from the brain resulting in poisoning and neurologic symptoms ranging from tremors, anorexia and excess salivation to blindness, coma and even death. Some of these drugs such as Ivermectins, which vets prescribe extensively for the treatment of parasite infections, are able to cause toxicity at 1/200th of the dose required to cause toxicity in healthy dogs..
Also known as Hereditary Polyneuropathy of Alaskan Malamute (HPAM), and Idiopathic Polyneuropathy of Alaskan Malamute (IPAM).
Polyneuropathy causes undersupply of the peripheric nervous system followed by nerve degeneration. Due to the lack of nervous stimulation the muscles degrade gradually. The causal mutation in Alaskan Malamute differs from the known mutation in Greyhound breed. The Mutation in Alaskan Malamute has been investigated by Prof. Dr. Merete Fredholm together with an international team of researchers.
The onset of clinical symptoms occurs during the first two years of a dog's life. These symptoms include progressive amyosthenia, exercise intolerance, loss of reflexes and ataxia of all limbs. So, the dog may fall down, walk on the tops of its feet or the gait may just look a little off. When palsy affects the larynx, changes in voice and problems in swallowing and regurgitating have also been described. The general condition is not influenced by the disease.
Subaortic stenosis is one of the most frequent hereditary heart failures in dogs. Due to abnormal tissue in the left ventricular outflow tract the blood flow is impeded. Symptoms show a huge variety: although dogs with a mild form of the disease may have a normal lifespan and life quality, severely affected animals may undergo life-threatening arrhythmias, congestive heart failure and sudden death. The investigated genetic variant shows a strong association with this disease. So a genetic test can help to decrease prevalence of mutation in this breed....
Digital Hyperkeratosis (DH) (Hereditary Footpad Hyperkeratosis / Corny Feet)in Irish Terrier and Kromfohrl�nder
This disease is also called �Corny Feet� as the main symptom is thickening and hardening of the footpads. Affected dogs suffer from painful cracks and crevices sometimes leading to secondary infections. Additionally, nail growth is accelerated so that nails become deformed and crumbly. As footpads and nails are cared for, the dog's lifespan and quality of life are normal....
Thrombopathia (Thrombopathy) IN Basset Hound and Landseer
Thrombopathia (Thrombopathy) is an inherited disease found in Basset Hound and Landseer. It affects the blood ability to stop bleeding from damaged / injured blood vessels.
Thrombocytes (Platelets) are small blood cells that respond to damage or injury of blood vessels by sticking to each other at the damaged site to plug holes until blood clotting and tissue repair can occur. In affected dogs, thrombocytes fail to respond to the damage in the blood vessel and therefore thrombocyte clumping does not occur. Affected dogs
in Nova Scotia Duck Tolling Retriever (NSDTR)
At the request of the
Nova Scotia Duck Tolling Retriever
breed club, the
has approved an new official DNA testing scheme for Degenerative
Myelopathy in Nova Scotia Duck
Canine degenerative myelopathy (also known as chronic degenerative radiculomyelopathy) is a progressive disease of the spinal cord in older dogs. The disease has an insidious onset typically between 7 and 14 years of age. It begins with a loss of coordination (ataxia) in the hind limbs
LABOKLIN offers 10% to members of theKennel
Kennel Club Assured
been working in cooperation with the Kennel Club for over five years.
tests are part of the Kennel CLub Official DNA testing schemes.
In continuing our support for breeding healthy dogs,Laboklinis
pleased to announce that members of the Kennel Club Assured Breeder
Scheme (ABS) are now eligible for10%
all genetic tests offered byLaboklin.
Please note that this offer cannot be used in
conjunction with other offers example at Crufts, special combination
For customers who would like
send samples to Optigen in USA, you can now send your samples to our
Manchester address and we will do everything else ... and where a Kennel
Club DNA Testing Scheme is in place, results will also be recorded by
Protein Losing Nephropathy (PLN) is an
inherited disease that affect Soft-Coated Wheaten Terriers and results
in essential proteins being lost through the kidney. The disease can be
mild and stable for years, however, it may lead to severe complications
including kidney failure. Progression of the symptoms is variable and
often influenced by environmental factors.
Primary Ciliary Dyskinesia (PCD) is an
autosomal-recessive genetic disease characterized by recurrent
infections of the respiratory tract as well as reduced male fertility.
Around 50% of the affected dogs develop situs inversus (Kartagener
Polycystic Kidney Disease is a genetic slow progressing and irreversible
disease characterised by the presence of cysts in the functional areas
of the kidneys, The size of the cysts varies from 0.5 mm to 2.5 mm.
Cysts grow and expand replacing the normal kidney tissue, as a result,
the functionality of the kidneys declines, the disease is likely to end
with chronic renal failure in middle to old aged dogs. The disease
affects both kidneys.
Late onset ataxia (LOA) in the Parson Russell
Terrier is a genetic disease characterised by progressive gait
incoordination and loss of balance. Early symptoms are usually seen at
the age of 6-12 month, the disease progresses, gait becomes increasingly
incoordinated with difficulty in moving around or complete loss of
Pompe's disease or GSDII (Glycogen Storage Disease Type II) is caused by
deficiency of the acid alpha-glucosidase enzyme which leads to
accumulation of glycogen in the cells, and this results in abnormal
glucose levels in tissues such as cardiac, skeletal, and smooth muscle.
Muscular Dystrophy (MD) was only valid for
Golden Retriever but now Cavalier King Charles Spaniel has been added to
the affected breed list.
Muscular Dystrophy (MD) is a spontaneous, X-linked, progressively
fatal disease of dogs and is also a homologue of Duchenne muscular
dystrophy (DMD). Affected dogs show raised creatine kinase levels,
muscle atrophy with contractures, hyaline myofiber degeneration with
mineralization, endomysial and perimysial fibrosis with fatty
infiltration, and cardiomyopathy.
Neuronal Ceroid Lipofuscinosis (NCL) was offered for
Australian Shepherd , Border collie , Dachshund , Miniature Long Haired
Dachshund , Miniature Smooth Haired Dachshund , American Bulldog ,
English Setter and Tibet Terrier breeds, now
American Staffordshire Terrier has been added to the list.
Hereditary Nasal Parakeratosis a genetic disorder that causes the dog's
nose to dry, especially, the upper surface of the planum forms
keratinous scales, which adhere to the nose. Bloody fissures might occur
in this structures, leading to chronic irritation and inflammation of
the noses skin.