Congenital Hypothyroidism with Dwarfism (CH) in Rottweilers
Congenital Hypothyroidism with Dwarfism (CH) in Rottweilers is caused by a variant in the TG gene, which is essential for producing the thyroid hormones T3 and T4. These hormones play a key role in growth, skeletal development and metabolic regulation. When the TG gene is altered, the thyroid gland cannot produce sufficient hormone, leading to a distinct inherited form of hypothyroidism that appears early in life.
Affected puppies are noticeably smaller and lighter than their littermates and show disproportionate dwarfism. Typical clinical signs include limb deformities, a shortened tail, unusually thick skin, delayed development and pain during movement. Unlike many other forms of hypothyroidism, this condition is generally not associated with goitre formation. Thyroid hormone replacement therapy may improve some symptoms, but it usually cannot fully prevent the developmental abnormalities.
The genetic test reliably identifies dogs that carry the TG variant. This supports responsible breeding decisions, helping to prevent the birth of affected puppies and reduce the spread of the mutation within the breed over time. For breeders and breed clubs, testing provides an important tool for safeguarding the long-term health and genetic diversity of the Rottweiler population.
