LABOKLIN (UK)| Genetic Diseases | Cats| Atherosclerosis (ATH) / Feline LDLR Associated Atherosclerosis

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Atherosclerosis (ATH) / Feline LDLR Associated Atherosclerosis Test number: 8946 Gene: ATH Price: £ 48.00 (including VAT)

Breed

Korat .

Description

New DNA Test for Feline Atherosclerosis

We are excited to introduce a DNA test for Atherosclerosis in cats

About the Condition

Atherosclerosis is a chronic inflammatory vascular disease caused by the accumulation of Low Density Lipoprotein LDL-derived cholesterol on arterial walls. While this condition is common in humans, it is rare in animals. Recent research has identified spontaneous cases of atherosclerosis in Korat cats, marked by severe hypercholesterolemia and clinical signs of congestive heart failure. These findings revealed histopathological similarities to human atherosclerosis.

Why Test?

Our DNA test targets this specific genetic variant, providing valuable insights for breeders, veterinarians, and researchers. Early identification of this mutation can help manage the health of affected cats and guide breeding decisions to reduce its prevalence.

Trait of Inheritance

LDLR-associated atherosclerosis in cats seems to follow a recessive inheritance pattern.

Inheritance : AUTOSOMAL RECESSIVE trait

Sire	Dam	Offspring

clear	clear	100% clear

clear	carrier	50% clear + 50% carriers

clear	affected	100% carriers

carrier	clear	50% clear + 50% carriers

carrier	carrier	25% clear + 25% affected + 50% carriers

carrier	affected	50% carriers + 50% affected

affected	clear	100% carriers

affected	carrier	50% carriers + 50% affected

affected	affected	100% affected

Clear

Genotype: N / N [ Homozygous normal ]

The cat is noncarrier of the mutant gene.
It is very unlikely that the cat will develop Atherosclerosis (ATH) / Feline LDLR Associated Atherosclerosis. The cat will never pass the mutation to its offspring, and therefore it can be bred to any other cat.

Carrier

Genotype: N / ATH [ Heterozygous ]

The cat carries one copy of the mutant gene and one copy of the normal gene.
It is very unlikely that the cat will develop Atherosclerosis (ATH) / Feline LDLR Associated Atherosclerosis but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%.
Carriers should only be bred to clear cats.
Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)

Affected

Genotype: ATH / ATH [ Homozygous mutant ]

The cat carries two copies of the mutant gene and therefore it will pass the mutant gene to its entire offspring.
The cat is likely to develop Atherosclerosis (ATH) / Feline LDLR Associated Atherosclerosis and will pass the mutant gene to its entire offspring

Sample Requirements

Whole blood in EDTA tube (0.5 - 1 ml) or Buccal Swabs.

Turnaround

2-4 weeks

Price

£ 48.00 (including VAT)

To order:

Download Order Form from this link
Complete the order form and send it together with your samples to the following address:
Laboklin (UK), Unit 20, Wheel Forge Way, Trafford Park, Manchester, M17 1EH
Buccal swabs and EDTA tubes are available from us free of charge, to order, please use the online form <Request sample collection materials> or email: info@laboklin.co.uk.
If you are sending swab samples, please follow the instructions on this link .